Abstract
The cardiotropic activities of 111 diterpene alkaloids and their synthetic derivatives having lycoctine, heteratisine, napelline, and denudatine skeletons have been studied. It has been established that the overwhelming majority of these compounds exhibit a pronounced antiarrhythmic and antifibrillatory action, which is a finding of practical interest. Their structure-activity relationships — the directions of their action in relation to the results of x-ray structural analysis — have been investigated. The following have been selected and proposed as antiarrhythmic agents for practical medicine: lappaconitine, deacetyllappaconitine, 6-benzoylheteratisine, 14-benzoyl talatisamine, 1-benzoylnapelline, and others. Of them, lappaconitine hydrobromide (allapinin) has been introduced into public health practice.
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Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax (3712) 40 64 75. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 254–270, March–April, 1997.
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Dzhakhangirov, F.N., Sultankhodzhaev, M.N., Tashkhodzhaev, B. et al. Diterpenoid alkaloids as a new class of antiarrhythmic agents. Structure-activity relationship. Chem Nat Compd 33, 190–202 (1997). https://doi.org/10.1007/BF02291540
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DOI: https://doi.org/10.1007/BF02291540