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Subcutaneous botulinum toxin type A inhibits regional sweating: an individual observation

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Abstract

Botulinum toxin inhibits neuromuscular transmission by blocking the exocytosis of acetylcholine. It was tested for a similar effect on cholinergic postganglionic sympathetic neurones at the sudomotor junction. Subcutaneous injections of 0.1 and 1.0 units of type A botulinum toxin into the forearm of a healthy subject abolished local thermoregulatory sweating in cutaneous regions spanning 1.0 and 1.5 cm for nearly 1 year without producing weakness. Botulinum toxin, therefore appears to have potent anhidrotic activity.

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Authors and Affiliations

  1. Department of Neurology, Mayo Clinic Jacksonville, 4500 San Pablo Road, 32224, Jacksonville, Florida, USA

    W. P. Cheshire MD

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  1. W. P. Cheshire MD
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Cheshire, W.P. Subcutaneous botulinum toxin type A inhibits regional sweating: an individual observation. Clinical Autonomic Research 6, 123–124 (1996). https://doi.org/10.1007/BF02291235

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  • DOI: https://doi.org/10.1007/BF02291235

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