Abstract
Magnetic resonance imaging (MRI) studies of the brain were reviewed in 16 patients with amyotrophic lateral sclerosis (ALS), representative of a large and homogeneously studied series, 11 of whom showed signal abnormalities along the pyramidal tracts. These were more frequent in patients with more severe upper motor neuron signs but did not correlate with disease severity. Our study suggests that MRI signal abnormalities along the pyramidal tracts are common in ALS and may reflect the severity of pyramidal tract degeneration.
Sommario
Abbiamo considerato le risonanze nucleari magnetiche eseguite in 16 di un gruppo più ampio di pazienti con sclerosi laterale amiotrofica. Anomalie di segnale lungo i fasci piramidali erano osservabili in 11 pazienti ed erano più frequenti in coloro i quali presentavano una maggiore compromissione del primo motoneurone. Non vi era correlazione con la durata né con la severità della malattia. Il nostro studio suggerisce che le alterazioni di segnale mostrate dalla MRI lungo i fasci piramidali sono di frequente riscontronella ALS e possono riflettere la gravità della degenerazione dei fasci piramidali.
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Carella, F., Grisoli, M., Savoiardo, M. et al. Magnetic resonance signal abnormalities along the pyramidal tracts in amyotrophic lateral sclerosis. Ital J Neuro Sci 16, 511–515 (1995). https://doi.org/10.1007/BF02282908
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DOI: https://doi.org/10.1007/BF02282908