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Impaired interhemispheric integration in brain oxygenation and hemodynamics in schizophrenia

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Abstract

We examined 38 patients with chronic schizophrenia to find and qualify disturbances in interhemispheric integration in brain oxygen metabolism and hemodynamics during a psychological task. A group of thirty-eight age- and sex-matched healthy volunteers were monitored as controls. Multi channel near-infrared (NIR) spectrophotometry was used to observe real-time alterations in cerebral oxygenation in areas of both hemispheres of the forebrain adjacent to the forehead during the mirror drawing task (MDT). In response to MDT normal volunteers showed distinct and well-integrated patterns of changes in oxygenated hemoglobin Hb, deoxygenated Hb, and blood volume total Hb. On the other hand, half the schizophrenics showeddysregulated patterns between hemispheres which never appeared in normal volunteers. Certain schizophrenic symptoms may be related to defective interhemispheric integration.

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Authors and Affiliations

  1. Health Administration Center, Hokkaido University, 060, Sapporo, Japan

    Fumihiko Okada

  2. Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University, 060, Sapporo, Japan

    Yukiko Tokumitsu

  3. Institute for Electronic Science, Hokkaido University, 060, Sapporo, Japan

    Yoko Hoshi & Mamoru Tamura

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  1. Fumihiko Okada
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  2. Yukiko Tokumitsu
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  3. Yoko Hoshi
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  4. Mamoru Tamura
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Okada, F., Tokumitsu, Y., Hoshi, Y. et al. Impaired interhemispheric integration in brain oxygenation and hemodynamics in schizophrenia. Eur Arch Psychiatry Clin Nuerosci 244, 17–25 (1994). https://doi.org/10.1007/BF02279807

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  • DOI: https://doi.org/10.1007/BF02279807

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