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A comparative study of the derivatisation of salicylic acid and acetylsalicylic acid with BSTFA, MSTFA and methyl iodide in presence of potassium carbonate prior to GLC determination

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Summary

The silylating reagents BSTFA and MSTFA are along with methyl iodide +K2CO3 useful for the derivatisation of salicylic acid and acetylsalicylic acid prior to GLC determination. The determination of traces of salicylic acid in acetylsalicylic acid bulk using BSTFA and MSTFA led also to the slight hydrolysis of acetylsalicylic acid. A column chromatographic separation seems here also necessary. A 2 m glass 3% OV-17 on Varaport 30, 70–80 mesh, AW/DMCS column was used.

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Literature

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  1. Zentrallaboratorium Deutscher Apotheker, Beethovenplatz 1-3, D-6, Frankfurt/Main, West Germany

    S. Laik Ali

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  1. S. Laik Ali
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Ali, S.L. A comparative study of the derivatisation of salicylic acid and acetylsalicylic acid with BSTFA, MSTFA and methyl iodide in presence of potassium carbonate prior to GLC determination. Chromatographia 8, 33–34 (1975). https://doi.org/10.1007/BF02279277

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  • DOI: https://doi.org/10.1007/BF02279277

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