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Fast chromatographic separation of (−)-menthyl chloroformate derivatives of some chiral drugs, with special reference to amlodipine, on porous graphitic carbon

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Summary

Enantiomeric separation of (−)-menthyl chloroformate derivatives of some chiral cardioactive drugs, on porous graphitic carbon (PGC), Hypercarb-S, is described. Capacity and separation factors of derivatives of the calcium channel blockers; amlodipine and UK52.829, the β-blockers; atenolol, sotalol and propranolol, and mexiletine were studied in different chromatographic systems based on dichloromethane. A high content of a carboxylic acid in the mobile phase was found to decrease the retention and positively affect the stereoselectivity of the derivatives. A mobile phase with dichloromethane, acetonitrile and formic acid gave baseline separation of the enantiomers of amlodipine in less than 8 minutes. Results show that acetic acid and formic acid, may be regarded as strong organic solvents in PGC chromatography with nearly the same elution power as dichloromethane.

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Authors and Affiliations

  1. Department of Clinical Pharmacology, Faculty of Health Sciences, Linköping University, 581 83, Linköping, Sweden

    M. Josefsson, B. Carlsson & B. Norlander

Authors
  1. M. Josefsson
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  2. B. Carlsson
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  3. B. Norlander
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Josefsson, M., Carlsson, B. & Norlander, B. Fast chromatographic separation of (−)-menthyl chloroformate derivatives of some chiral drugs, with special reference to amlodipine, on porous graphitic carbon. Chromatographia 37, 129–132 (1993). https://doi.org/10.1007/BF02275849

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  • DOI: https://doi.org/10.1007/BF02275849

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