References
Shemin, D., andD. Rittenberg: The utilization of glycine for the synthesis of a porphyrin. J. of Biol. Chem.159, 567 (1945).
——: The biological utilization of glycine for the synthesis of the protoporphyrin of hemoglobin. J. of Biol. Chem.166, 621 (1946).
——: The life span of the human red blood cell. J. of Biol. Chem.166, 627 (1946).
London, I. M., D. Shemin, R. West andD. Rittenberg: Heme synthesis and red blood cell dynamics in normal humans and in subjects with polycythemia vera, sickle-cell anemia, and pernicious anemia. J. of Biol. Chem.179, 463 (1949).
Gray, C. H., andA. Neuberger: Studies in congenital porphyria. I. Incorporation of N15 with coproporphyrin, uroporphyrin and hippuric acid. Biochem. J.47, 81 (1950).
Shemin, D.: The biosynthesis of porphyrins. Cold Spring Harbor Symp. Quant. Biol.13, 185 (1948).
Wittenberg, J., andD. Shemin: The utilization of glycine for the biosynthesis of both types of pyrroles in protoporphyrin. J. of Biol. Chem.178, 47 (1949).
Muir, H. M., andA. Neuberger: The biogenesis of porphyrins. The distribution of N15 in the ring system. Biochemic. J.43, lx (1948);45, 163 (1949).
Shemin, D., I. M. London andD. Rittenberg: The synthesis of protoporphyrin in vitro by red blood cells of the duck. J. of Biol. Chem.173, 799 (1948);183, 757 (1950).
London, I. M., D. Shemin andD. Rittenberg: Synthesis of heme in vitro by the immature non-nucleated mammalian erythrocyte. J. of Biol. Chem.173, 797 (1948);183, 749 (1950).
Altman, K. I., G. W. Casarett, R. E. Masters, T. R. Noonan andK. Solomon: Hemoglobin synthesis from glycine labeled with radioactive carbon in its α-carbon atom. J. of Biol. Chem.176, 319 (1948).
Radin, N., D. Rittenberg andD. Shemin: The role of glycine in the biosynthesis of heme. Federat. Proc.8, 240 (1949). — J. Biol. Chem.184, 745 (1950).
Wittenberg, J., andD. Shemin: The location in protoporphyrin of the carbon atoms derived from the α-carbon atom of glycine. J. of Biol. Chem.185, 103 (1950).
Muir, H. M., andA. Neuberger: The biogenesis of porphyrins. 2. The origin of the methyne carbon atoms. Biochemic. J.45, XXXIV (1949);47, 97 (1950).
Grinstein, M., M. Kamen andC. V. Moore: Observation on the utilization of glycine in the biosynthesis of hemoglobin. J. of Biol. Chem.174, 767 (1948).
Shemin, D., andJ. Wittenberg: The mechanism of porphyrin formation. The role of the tricarboxylic acid cycle. J. of Biol. Chem.192, 315 (1951). Isotopes in biochemistry. Ciba Found. Conf. London, Churchill, p. 41, 1951.
— Some aspects of the biosynthesis of amino acids. Cold Spring Harbor Symp. Quant. Biol.14, 161 (1949).
Bloch, K., andD. Rittenberg: An estimation of acetic acid formation in the rat. J. of Biol. Chem.159, 45 (1945).
Radin, N. S., D. Rittenberg andD. Shemin: The role of acetic acid in the biosynthesis of heme. Federat. Proc.8, 240 (1949). — J. of Biol. Chem.184, 755 (1950).
Shemin, D., andS. Kumin: The mechanism of porphyrin formation. The formation of a succinyl intermediate from succinate. J. of Biol. Chem.198, 827 (1952).
Wriston, J. C., L. Lack andD. Shemin: The mechanism of porphyrin formation. Further evidence on the relationship of the citric acid cycle and porphyrin formation. Federat. Proc.12, 294 (1953). — J. of Biol. Chem.215, 603 (1955).
London, I. M., andM. Yamasaki: Heme synthesis in non-intact mammalian and avian erythrocytes. Federat. Proc.11, 250 (1952).
Shemin, D., andC. S. Russell: δ-Aminolevulinic acid; its role in the biosynthesis of porphyrins and purines. J. Amer. Chem. Soc.75, 4873 (1953).
—,T. Abramsky andC. S. Russell: The synthesis of protoporphyrin from δ-aminolevulinic acid in a cell-free extract. J. Amer. Chem. Soc.76, 1204 (1954).
—,C. S. Russell andT. Abramsky: The succinate-glycine cycle. I. The mechanism of pyrrole synthesis. J. of Biol. Chem.215, 613 (1955).
Schiffmann, E., andD. Shemin: The conversion of δ-aminolevulinic acid to protoporphyrin. J. of Biol. Chem. (in press).
Neuberger, A., andJ. J. Scott: Aminolevulinic acid and porphyrin biosynthesis. Nature (Lond.)172, 1093 (1953).
Dresel, E. I. B., andJ. E. Falk: Conversion of δ-aminolevulinic acid to porphobilinogen in a tissue system. Nature (Lond.)172, 1185 (1953).
Westall, R. G.: Isolation of porphobilinogen from the urine of a patient with acute porphyria. Nature (Lond.)170, 614 (1952).
Cookson, G. H., andC. Rimington: Porphobilinogen. Chemical constitution. Nature (Lond.)171, 875 (1953).
Weliky, I., andD. Shemin: The metabolism of α-amino-β-ketoadipic acid. Unpublished observations.
Gibson, K. D., A. Neuberger andJ. J. Scott: The enzymic conversion of δ-aminolevulic acid to porphobilinogen. Biochemic. J.58, XLI (1954).
———: The purification and properties of δ-aminolaevulic acid dehydrase. Biochemic. J.61, 6181 (1955).
Schmid, R., andD. Shemin: The enzymatic formation of porphobilinogen from δ-aminolevulinic acid and its conversion to protoporphyrin. J. Amer. Chem. Soc.77, 506 (1955).
Granick, S.: Enzymatic conversion of δ-aminolevulinic acid to porphobilinogen. Science (Lancaster, Pa.)120, 1105 (1954).
Falk, J. E., E. I. B. Dresel andC. Rimington: Porphobilinogen as a porphyrin precursor, and interconversion of porphyrins in a tissue system. Nature (Lond.)172, 292 (1953).
Bogorad, L., andS. Granick: The enzymic synthesis of porphyrins from porphobilinogen. Proc. Nat. Acad. Sci. U.S.A.39, 1176 (1953).
Cookson, G. H., andC. Rimington: Porphobilinogen. Biochemic. J.57, 476 (1954).
Corwin, A. H., andJ. S. Andrews: Studies in the pyrrole series. III. The relation of tripyrrolmethane cleavage to methene synthesis. J. Amer. Chem. Soc.59, 1973 (1937).
Andrews, J. S., A. H. Corwin andA. G. Sharp: 1,4,5,8-Tetramethyl-2,3,6,7-tetra-carbethoxyporphyrin and some derivatives. J. Amer. Chem. Soc.72, 491 (1950).
Neve, R. A., R. F. Labbe andR. A. Aldrich: Reduced uroporphyrin III in the biosynthesis of heme. J. Amer. Chem. Soc.78, 691 (1956).
Karlsson, J. L., andH. A. Barker: Biosynthesis of uric acid labeled with radioactive carbon. J. of Biol. Chem.177, 597 (1949).
Sakami, W.: The conversion of glycine into serine in the intact rat. J. of Biol. Chem.178, 519 (1949).
Winnick, T., I. Moring-Claesson andD. M. Greenberg: Distribution of radioactive carbon among certain amino acids of liver homogenate protein, following uptake experiments with labeled glycine. J. of Biol. Chem.175, 127 (1948).
Arnstein, H. R. V.: The biosynthesis of choline methyl groups in the rat. Biochemic. J.47, XVIII (1950).
Jonsson S., andW. A. Mosher: Thein vivo synthesis of labile methyl groups. J. Amer. Chem. Soc.72, 3316 (1950).
Weissbach, A., D. Elwyn andD. B. Sprinson: The synthesis of the methyl groups and enthanolamine moiety of choline from serine and glycine in the rat. J. Amer. Chem. Soc.72, 3316 (1950).
Russell, C. S., S. Gatt, G. L. Foster andD. Shemin: Unpublished observations.
Gatt, S., andD. Shemin: The metabolism of aminoacetone and its relation to glycine metabolism. Ph.D. dissertation, Columbia University, 1955.—Shemin, D., in: Amino acid metabolism (W. D. McElroy andB. Glass). Baltimore: The Johns Hopkins Press 1955.
Scott, J. J.: The metabolism of δ-aminolaevulic acid. In: The biosynthesis of porphyrins and porphyrin metabolism, p. 43. Ciba Found. Conf. London: Churchill, 1955.
Nemeth, A., C. S. Russell andD. Shemin: The succinate-glycine cycle: the metabolism of δ-aminolevulinic acid. Manuscript in preparation.
Labbe, R. F., T. Abramsky andD. Shemin: Studies on the formation of δ-aminolevulinic. Manuscript in preparation.
Hodgkin, D. C., S. Pickworth, J. H. Robertson, K. Trueblood, R. J. Piozen andJ. G. White: Structure of vitamins B12. Nature (Lond.)176, 325 (1955).
Bonnett, R., J. R. Cannon, A. W. Johnson, I. Sutherland, A. R. Todd andE. L. Smith: The structure of vitamin B12 and its hexacarboxylic acid degradation product. Nature (Lond.)176, 328 (1955).
Shemin, D., J. W. Corcoran, C. Rosenblum andI. M. Miller: On the biosynthesis of porphyrin-like moiety of vitamin B12. Science124, 272 (1956).
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This work was supported by grants from the National Institutes of Health, United States Public Health Service (A-1101 (C7)), from the American Cancer Society on the recommendation of the Commitee on Growth of the National Research Council, from the Rockefeller Foundation and from the Williams-Waterman Fund.
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Shemin, D. The biosynthesis of porphyrins. Ergebnisse der Physiologie und exper. Pharmakologie 49, 299–326 (1957). https://doi.org/10.1007/BF02269486
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DOI: https://doi.org/10.1007/BF02269486