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HbF-Lesvos: An HbF variant due to a novel Gγ mutation (:Gγ 75 ATA→ACA) detected in a Greek family

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Abstract

A T→C substitution at position 402 of the Gγ globin gene results in an isoleucine to threonine substitution at codon 75 of the Gγ globin chain and the formation of HbF-Lesvos [α2Gγ2 75 (E19) Ile→Thr].

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Authors and Affiliations

  1. Center for Thalassemia Unit of Prenatal Diagnosis, 16, “LAIKON” General Hospital, Sevastoupoleos str, Ampelokipi, GR-115 26, Athens, Greece

    Manoussos N. Papadakis, George P. Patrinos, Olga Drakoulakou & Aphrodite Loutradi-Anagnostou

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  1. Manoussos N. Papadakis
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  2. George P. Patrinos
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  3. Olga Drakoulakou
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  4. Aphrodite Loutradi-Anagnostou
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Papadakis, M.N., Patrinos, G.P., Drakoulakou, O. et al. HbF-Lesvos: An HbF variant due to a novel Gγ mutation (:Gγ 75 ATA→ACA) detected in a Greek family. Hum Genet 97, 260–262 (1996). https://doi.org/10.1007/BF02265278

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  • DOI: https://doi.org/10.1007/BF02265278

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