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Enantiomer separations with chromatographic supports based on β-cyclodextrin polymers immobilized on porous silica. Role of the polymer structure in separating ability

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Summary

Two β-cyclodextrin (β-CD)-containing polymers have been prepared either by condensation of β-CD molecules with a bifunctional reagent or by grafting a β-CD derivative on to a linear polymer (polyvinylimidazole). HPLC stationary phases were obtained by adsorption of the β-CD polymers on to silica. The ability of these chromatographic supports to resolve racemic mixtures of organic compounds such as amino acid derivatives, phenylhydantoins, barbiturates, and hydroxycoumarin derivatives has been investigated. Results were found to depend on the chemical structure of the β-CD polymers

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Authors and Affiliations

  1. Laboratoire de Physico-Chimie des Biopolymères, U.M.R. 27, C.N.R.S., Université de Paris XII, 2, rue Henri Dunant, 94320, Thiais, France

    N. Thuaud, B. Sébille, A. Deratani, B. Pöpping & C. Pellet

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  1. N. Thuaud
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  2. B. Sébille
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  3. A. Deratani
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  4. B. Pöpping
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  5. C. Pellet
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Thuaud, N., Sébille, B., Deratani, A. et al. Enantiomer separations with chromatographic supports based on β-cyclodextrin polymers immobilized on porous silica. Role of the polymer structure in separating ability. Chromatographia 36, 373–380 (1993). https://doi.org/10.1007/BF02263896

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  • DOI: https://doi.org/10.1007/BF02263896

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