Summary
The synthesis of a cyclam (1,4,8,11-tetraazacyclo-tetradecane)-bonded silica is described. The effect of pH, ionic strength and methanol content of the mobile phase on the chromatographic behaviour of the stationary phase when loaded with Cu(II) has been studied. Retention is observed only for compounds whose net charge is negative at the pH used. This selectivity proves to result from outer-sphere ligand-exchange chromatography. The separation of isomers of amino benzoic acid and of acidic derivatives of indole have been achieved.
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References
H. F. Walton, R. H. Stokes, J. Am. Chem. Soc.76, 3327 (1954).
F. Hellferich, Nature (London)189, 1001 (1961).
F. Hellferich, J. Am. Chem. Soc.84, 3237 and 3242 (1962).
A. V. Davankov, A. V. Semechkin, J. Chromatogr.141, 313 (1977).
D. Kunzru, R. W. Frei, J. Chromatogr. Sci.12, 191 (1974).
R. Aigner, R. W. Frei, Anal. Chem.48, 2 (1976).
A. Foucault, M. Caude, L. Olivaros, J. Chromatogr.185, 345 (1979).
N. H. C. Cooke, R. L. Viavattene, R. Eksteen, W. S. Wong, G. Davies, B. L. Karger, J. Chromatogr.149, 391 (1978).
F. K. Chow, E. Grushka, J. Chromatogr.185, 361 (1979).
M. A. Bagnoud, J. L. Veuthey, W. Haerdi, Chimia40, 432 (1986).
M. A. Bagnoud, W. Haerdi, Int. J. Environ. Anal. Chem.38, 97 (1990).
M. Glad, S. Ohlson, L. Hansson, M. O. Manson, K. Mosbach, J. Chromatogr.200, 254 (1980).
A. I. Vogel, “Textbook of Quantitative Inorganic Analysis”, 4th ed., Longman, London (1978).
M. A. Bagnoud, “Synthèses, Propriètés et Applications de Silices Greffées, dont une en particulier par le 1,4,8,11-Tétraazacyclotétradécane (Cyclame)”, Thesis, University of Geneva (1989).
A. E. Martell, R. M. Smith, “Critical Stability Constants”, Plenum Press, New York and London (1974–1989).
D. A. Richards, J. Chromatogr.175, 293 (1979).
E. Schmidt, A. Foucault, M. Caude, R. Rosset, Analusis7, 366 (1979).
D. D. Perrin, IUPAC Chemical Data Series, no 22 “Stability Constants of Metal-ion Complexes. Part B: Organic Ligands”, Pergamon Press (1979).
M. T. Beck, Coord. Chem. Rev.3, 91 (1968).
R. D. Hancock, E. A. Darling, R. H. Hodgson, Ka. Ganesh, Inorg. Chim. Acta90, L83 (1984).
W. Funasaka, K. Fujimara, S. Kuriyama, Japan Analyst19, 104 (1970).
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Bagnoud, M.A., Haerdi, W. & Veuthey, J.L. Outer-sphere ligand-exchange chromatography with copper-loaded macrocyclic-bonded silica column. Chromatographia 29, 495–499 (1990). https://doi.org/10.1007/BF02261400
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DOI: https://doi.org/10.1007/BF02261400