Summary
Following the administration of yohimbine, an α2-adrenoreceptor antagonist, the levels of norepinephrine (NE), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5HIAA) increased significantly in the lateral ventricular fluid of rats. These increases were abolished when animals were pretreated with α-methyl-para-tyrosine or reserpine. Dopamine (DA) was not detected in ventricular fluid either before or after yohimbine administration. Yohimbine administration did, however, increase intracellular DA levels in the corpus striatum. These findings indicate that yohimbine promotes NE and DA release in the brain and suggest that it also modifies the activity of the serotonin system.
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References
Anden N-E, Grabowska M (1976) Pharmacological evidence for a stimulation of dopamine neurons by noradrenaline neurons in the brain. Eur J Pharmacol 39: 275–282
Boissier JR, Simon P, Guidicelli JF (1968) Effects centraux de quelques substances adreno et/ou sympatholytiques. III. Ptosis, catalepsie, antagonisme vis-a-vis de l'apomorpine et de l'amphetamine. Arch Int Pharmacodyn 171: 68–80
Brannan T, Bhardwaj A, Yahr MD (1990) L-threodops increases extracellular norepinephrine levels in the brain: an in vivo study. Neurology 40: 1134–1135
Dwoskin LP, Neal BS, Sparber SB (1988) Evidence for antiserotonergic properties of yohimbine. Pharmacol Biochem Behav 31: 321–326
Edwards DJ, Sorisio DA (1988) Differential effects of yohimbine and phenoxybenzamine on norepinephrine metabolites in rat brain. Res Commun Chem Pathol Pharmacol 62: 195–206
Goldberg MR, Robertson D (1983) Yohimbine: a pharmacological probe for study of the α2-adrenoreceptor. Pharmacol Rev 35: 143–180
Hedler L, Stamm G, Weitzell R, Starke K (1981) Functional characterization of central α-adrenoreceptors by yohimbine diastereomers. Eur J Pharmacol 70: 43–52
Lindvall O, Bjorklund A (1983) Dopamine and norepinephrine containing neuron systems: their anatomy in the rat brain. In: Emson PC (ed) Chemical neuroanatomy. Raven Press, New York, pp 229–254
Mignot E, Laude D, Elghozi JL, Le Quan-bui KH, Meyer P (1982) Central administration of yohimbine increased free 3-methoxyl-4-hydrophenylglycol in the cerebrospinal fluid of the rat. Eur J Pharmacol 83: 135–138
Montastruc JL, Puech AJ, Clanet M, Guirand-Chaumeil B, Rascol A (1981) La yohimbine dans le traitment de la maladie de Parkinson: Resultat preliminaire. Nouv Presse Med 10: 1331–1332
Narabayashi H (1983) Pharmacological basis of akinesia on Parkinson's disease. J Neural Transm [Suppl] 19: 143–151
Onrot J, Goldberg MR, Biaggioni I, Wiley RG, Hollister AS, Robertson D (1987) Oral yohimbine in human autonomic failure. Neurology 37: 215–220
Papeschi R, Sourkes TL, Youdim MBH (1971) The effect of yohimbine on brain serotonin metabolism, motor behavior and body temperature of the rat. Eur J Pharmacol 15: 318–326
Papeschi R (1974) An investigation on the behavioral and hypothermic effects of yohimbine: interaction with drugs affecting central and peripheral monoamines. Arch Int Pharmacodyn Ther 208: 61–74
Scatton B, Zivkovic B, Dedek J (1973) Antidopaminergic properties of yohimbine. J Pharmacol Exp Ther 215: 494–499
Slivka A, Brannan TS, Weinberger J, Knott PJ, Cohen G (1988) Increase in extracellular dopamine in the striatum during cerebral ischemia: a study utilizing cerebral microdialysis. J Neurochem 50: 1714–1718
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Brannan, T., Martinez-Tica, J. & Yahr, M.D. Effect of yohimbine on brain monoamines: An in vivo study. J Neural Transm Gen Sect 3, 81–87 (1991). https://doi.org/10.1007/BF02260883
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DOI: https://doi.org/10.1007/BF02260883