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Expression of ETS-1 related to angiogenesis in uterine endometrium during the menstrual cycle

  • Original Paper
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Journal of Biomedical Science

Abstract

ETS-1 has been identified as a transcription factor for angiogenesis, which is essential for the development and growth of the uterine endometrium. This characteristic prompted us to study whether ETS-1 functions as an angiogenic mediator in uterine endometrium. Immunohistochemical staining revealed that the localization of ETS-1 was similar to that of vascular endothelial cells. There was a significant correlation between microvessel counts and both ETS-1 histoscores and ets-1 mRNA levels in uterine endometrium. The ETS-1 histoscores and ets-1 mRNA levels increased in the proliferative phase, reached a peak during peri-ovulation and decreased in the secretory phase. Furthermore, the ETS-1 histoscores and ets-1 mRNA levels correlated with vascular endothelial growth factor (VEGF) levels in the proliferative phase. This indicates that ETS-1 might be an angiogenic mediator in uterine endometrium linked to VEGF in the proliferative phase.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa-machi, 500-8705, Gifu City, Japan

    Jiro Fujimoto, Ikumi Aoki, Hiroshi Toyoki, Sufia Khatun, Eriko Sato & Teruhiko Tamaya

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  1. Jiro Fujimoto
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  2. Ikumi Aoki
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  3. Hiroshi Toyoki
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  4. Sufia Khatun
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  5. Eriko Sato
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  6. Teruhiko Tamaya
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Fujimoto, J., Aoki, I., Toyoki, H. et al. Expression of ETS-1 related to angiogenesis in uterine endometrium during the menstrual cycle. J Biomed Sci 10, 320–327 (2003). https://doi.org/10.1007/BF02256451

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  • DOI: https://doi.org/10.1007/BF02256451

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