Skip to main content
SpringerLink
Log in

Clinical and roentgen features of the intestinal polyposis syndromes

  • Published:
Gastrointestinal Radiology Aims and scope Submit manuscript

Abstract

The intestinal polyposis syndromes represent a challenging diagnostic problem for the radiologist. These syndromes include: familial multiple polyposis, Gardner's, Peutz-Jeghers, Turcot's, Cronkhite-Canada and juvenile polyposis. The polyposis syndromes can usually be differentiated from one another on the basis of the clinical history, examination of the mucocutaneous tissues and roentgen findings. Numerous other conditions, however, may mimmic a polyposis syndrome, and must be considered in the differential diagnosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Pierce ER: Some genetic aspects of familial multiple polyposis of the colon in kindred of 1,422 members.Dis Colon Rectum 11:321–329, 1968

    Google Scholar 

  2. Reed TE, Neel JV: A genetic study of multiple polyposis of the colon (with an appendix deriving a method of estimating relative Fitness).Am J Hum Genet 7:236–263, 1955

    Google Scholar 

  3. Peck DA, Watanabe KS, Trueblood HW: Familial polyposis in children.Dis Colon Rectum 15:23–29, 1972

    Google Scholar 

  4. Dodds WJ, Lydon SB: Intestinal polyposis syndromes.CRC Critical Reviews in Clinical Radiology and Nuclear Medicine 5:295–336, 1974

    Google Scholar 

  5. Youker JE, Dodds WJ, Welin S: Colonic Polyps,Alimentary Tract Roentgenology, Vol. 2, Second edition. St. Louis. CV Mosby Co, 973, pp 1037–1067

  6. Cripps H: Two cases of disseminated polyps of the colon.Trans Pathol Soc Lond 33:165–168, 1882

    Google Scholar 

  7. Dukes CE: Familial intestinal polyposis.Ann R Call Surg Engl 10:292–304, 1952

    Google Scholar 

  8. Veale AMO:Intestinal Polyposis. London, Cambridge University Press, 1965

    Google Scholar 

  9. Bussey HJR: Progress report, gastrointestinal polyposis.Gut 11:970–978, 1970

    Google Scholar 

  10. Dorazio RA, Whelan TJ Jr: Lymphoid hyperplasia of the terminal ileum associated with familial polyposis coli.Ann Surg 171:300–302, 1970

    Google Scholar 

  11. Hoffmann DC, Goligher JC: Polyposis of the stomach and small intestine in association with familial polyposis coli.Br J Surg 58:126–128, 1971

    Google Scholar 

  12. Yonemoto RH, Slayback JB, Byron RL, Rosen RB: Familial polyposis of the entire gastrointestinal tract.Arch Surg 99:427–434, 1969

    Google Scholar 

  13. McConnell RB:The Genetics of Gastrointestinal Disorders. London, Oxford University Press, 1966

    Google Scholar 

  14. Sachatello CR: Familial polyposis of the colon, a four-decade follow-up.Cancer 28:581–587, 1971

    Google Scholar 

  15. Capps WF Jr, Lewis MI, Gazzaniga DA: Carcinoma of the colon, ampulla of Vater and urinary bladder associated with familial multiple polyposis.Dis Colon Rectum 11:298–305, 1968

    Google Scholar 

  16. Marshak RH, Moseley JE, Wolf BS: The roentgen findings in familial polyposis with special emphasis on differential diagnosis.Radiology 80:374–382 1963

    Google Scholar 

  17. Kennedy B, Dodds W.J., Schulte W, Hogan WJ, Hensley GT: Familial multiple polyposis: a “curable” disease.Wis Med J 70:230–232, 1971

    Google Scholar 

  18. Gruenberg J, Mackman S.: Multiple lymphoid polyps in familial polyposis.Ann Surg 175:552–554, 1972

    Google Scholar 

  19. Cole JW, McKalen A, Powel J: The role of ileal contents in the spontaneous regression of rectal adenomas.Dis Colon Rectum 4:413–418, 1961

    Google Scholar 

  20. Gardner, E.J., Richards RC: Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary polyposis and osteomatosis.Am J Hum Genet 5:139–147, 1953

    Google Scholar 

  21. Melmed RN, Rouchier IAD: Duodenal involvement in Gardner's syndrome.Gut 13:524–527, 1972

    Google Scholar 

  22. Coli RD, Moore JP, La Marche PH, De Luca FG, Thayer WR: Gardner's syndrome, a revisit to a previously described family.Am J Dig Dis 15:551–568, 1970

    Google Scholar 

  23. Simpson RD, Harrison EG Jr, Mayo CW: Mesenteric fibromatosis in familial polyposis, a variant of Gardner's syndrome.Cancer 17:526–534, 1964

    Google Scholar 

  24. Carillo FJ, Ruzicka FF Jr, Clemett AR: Value of angiography in the diagnosis of retractile mesenteritis.Am J Roentgenol Radium Ther Nucl Med 115:396–398, 1972

    Google Scholar 

  25. Chang CH, Piatt ED, Thomas KE, Watne AL: Bone abnormalities in Gardner's syndrome.Am J Roentgenol Radium Ther Nucl Med 103:645–652, 1968

    Google Scholar 

  26. Ziter MH: Roentgenographic findings in Gardner's syndrome.JAMA 192:158–160, 1965

    Google Scholar 

  27. Vanhoutte JJ: Polypoid lymphoid hyperplasia of the terminal ileum in patients with familial polyposis coli and with Gardner's syndrome.Am J Roentgenol Radium Ther Nucl Med 110:340–342, 1970

    Google Scholar 

  28. Watne AL, Johnson JG, Chang CH: The challenge of Gardner's syndrome.Cancer 19:266–275, 1969

    Google Scholar 

  29. Macdonald JM, Davis WC, Crago HR, Berk AD: Gardner's syndrome and periampullary malignancy.Am J Surg 113:425–430, 1967

    Google Scholar 

  30. McKusick VA: Genetic factors in intestinal polyposis.JAMA 182:271–277, 1962

    Google Scholar 

  31. Smith WG: Familial Multiple polyposis: research tool for investigating the etiology of carcinoma of the colon.Dis Colon Rectum 11:17–31, 1968

    Google Scholar 

  32. Oldfield MC: The association of familial polyposis of the colon with multiple sebaceous cysts.Br J Surg 41:534–541, 1954

    Google Scholar 

  33. Johnson JG, Gilbert E, Zimmermann B, Watne AL: Gardner's syndrome, colon cancer, and sarcoma.J Surg Oncol 4:354–362, 1972

    Google Scholar 

  34. Peutz JLA: Ober een zeer merkwaardige, geocombineerde familiare polyposis van de Slijmvliezen van den Tractus intestinalis met die van de Neuskeelholte en Gepaard met eigen aardige Pigmentaties van Huiden Slijmvliezen.Ned Tijdschr Geneeskd 10:134–146, 1921

    Google Scholar 

  35. Jeghers H, McKusick VA, Katz KH: Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits: a syndrome of diagnostic significance.N Engl J Med 241:933–1005, and 1031–1036, 1949

    Google Scholar 

  36. Bartholomew LG, Moore CE, Dahlin DC, Waugh JM: Intestinal polyposis associated with mucocutaneous pigmentation.Surg Gynecol Obstet 114:1–16, 1962

    Google Scholar 

  37. Burdick D, Prior J, Scanlon GT: Peutz-Jeghers syndrome: clinical-pathologic study of a large family with a 10-year follow-up.Cancer 16:854–867, 1963

    Google Scholar 

  38. Dodds WJ, Schulte WJ, Godard JE, Hogan WJ, Hensley GT: Investigation of a large negro family with Peutz-Jeghers syndrome.Gastroenterology 60:657, 1971.

    Google Scholar 

  39. Dormandy TL: Gastrointestinal polyposis with mucocutaneous pigmentation (Peutz-Jeghers syndrome).N Engl J Med 256: 1093–1103, 1141–1146, and 1186–1190, 1957

    Google Scholar 

  40. Dozois RR, Judd S, Dahlin DC, Bartholomew LG: The Peutz-Jeghers syndrome: is there a predisposition to the development of intestinal malignancy.Arch Surg 98:509–516, 1969

    Google Scholar 

  41. Sommerhaug RG, Mason T: Peutz-Jeghers syndrome and ureteral polyposis.JAMA 211:120–122, 1970

    Google Scholar 

  42. Jancu J: Peutz-Jeghers syndrome: involvement of the gastrointestinal and upper respiratory tracts.Am J Gastroenterol 56:545–549, 1971

    Google Scholar 

  43. Dodds WJ, Schulte WJ, Hensley GT, Hogan WJ: Peutz-Jeghers syndrome and gastrointestinal malignancy.Am J Roentgenol Radium Ther Nucl Med 115:374–377, 1972

    Google Scholar 

  44. Dozois RR, Kempers RD, Dahlin DC, Bartholomew LG: Ovarian tumors associated with the Peutz-Jeghers syndrome.Ann Surg 172:233–238, 1970

    Google Scholar 

  45. Sheward JD: Peutz-Jeghers syndrome in childhood: unusual radiological features.Br Med J I:921–923, 1962

    Google Scholar 

  46. Dodds WJ, Lydon SB, Stewart ET, Binder GA: Value of the tilt upside-down maneuver for roentgen examination of pelvic small-bowel loops.Am J Roentgenol Radium Ther Nucl Med 123:412–414, 1975

    Google Scholar 

  47. Godard JE, Dodds WJ, Phillips JC, Scanlon GT: Peutz-Jeghers syndrome: clinical and roentgenographic features.Am J Roentgenol Radium Ther Nucl Med 113:316–324, 1971

    Google Scholar 

  48. Fenlon JW, Schackelford GD: Peutz-Jeghers syndrome: case report with angiographic evaluation.Radiology 103:595–596, 1972

    Google Scholar 

  49. Turcot, J, Despres J, St Pierre F: Malignant tumors of the central nervous system associated with familial polyposis of the colon: report of two cases.Dis Colon Rectum 2:465–468, 1959

    Google Scholar 

  50. Baughman FW Jr, List CF, Williams JR, Muldoon JP, Segarra JM, Volkel JS: The glioma-polyposis syndrome.N Engl J Med 281:1345–1346, 1969

    Google Scholar 

  51. Crail HW: Multiple primary malignancies arising in the rectum, brain and thyroid.US Navy Med Bull 49:123–128, 1949

    Google Scholar 

  52. Cronkhite LW Jr, Canada WJ: Generalized gastrointestinal polyposis: an unusual syndrome of pigmentation, alopecia, and onychotrophia.N Engl J Med 252:1011–1015, 1955

    Google Scholar 

  53. Johnson GK, Soergel KH, Hensley GT, Dodds WJ, Hogan WJ: Cronkhite-Canada syndrome: gastrointestinal pathophysiology and morphology.Gastroenterology 63:140–152, 1972

    Google Scholar 

  54. Koehler PR, Kyaw MM, Fenlon JW: Diffuse Gastrointestinal polyposis with ectodermal changes: Cronkhite-Canada syndrome.Radiology 103:589–594, 1972

    Google Scholar 

  55. Johnston MM, Vosburgh JW, Wiens AT, Walsh GC: Gastrointestinal polyposis associated with alopecia, pigmentation, and atrophy of the fingernails and toenails.Ann Intern Med 56:935–940, 1962

    Google Scholar 

  56. Morson BC: Some peculiarities in the histology of intestinal polyps.Dis Colon Rectum 5:337–344, 1962

    Google Scholar 

  57. Haggitt RC, Picock JA: Familial juvenile polyposis of the colon.Cancer 26:1232–1238, 1970

    Google Scholar 

  58. Silverberg SG: “Juvenile” retention polyps of the colon and rectum.Am J Dig Dis 15:617–625, 1970

    Google Scholar 

  59. Holgersen LO, Miller RE, Zintel HA: Juvenile polyps of the colon.Surgery 69:288–293, 1971

    Google Scholar 

  60. Korobkin M, Shapiro H, Lawson D, Golden D, Palubinskas AJ: Arteriographic diagnosis of a juvenile cecal polyp.Gastroenterology 63:1059–1061, 1972

    Google Scholar 

  61. Veale AMO, McColl I, Bussey JR, Morson BC: Juvenile polyposis coli.J Med Genet 3:5–16, 1966

    Google Scholar 

  62. Ray JE, Heald RJ: Growing up with juvenile gastrointestinal polyposis: report of a case.Dis Colon Rectum 14:375–380, 1971

    Google Scholar 

  63. Ruymann FB: Juvenile polyps with cachexia. Report of an infant and comparison with Cronkhite-Canada syndrome in adults.Gastroenterology 57:431–438, 1969

    Google Scholar 

  64. Soper RT, Kent TH: Fatal juvenile polyposis in infancy.Surgery 69:692–698, 1971

    Google Scholar 

  65. Kaschula ROC: Mixed juvenile, adenomatous and intermediate polyposis coli: report of a case.Dis Colon Rectum 14:368–374, 1971

    Google Scholar 

  66. Woolf CM, Richards RC, Gardner EJ: Occasional discrete polyps of the colon and rectum showing an inherited tendency in a kindred.Cancer 8:403–408, 1955

    Google Scholar 

  67. Dunstone GH, Knaggs TWL: Familial cancer of the colon and rectum.J Med Genet 9:451–454, 1972

    Google Scholar 

  68. Lynch HT, Krush AJ: Cancer family “G” revisted: 1895–1970.Cancer 27:1505–1511, 1971

    Google Scholar 

  69. Lynch HT, Krush AJ: The cancer family syndrome and cancer control.Surg Gynecol Obstet 132:247–250, 1971

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology and Medicine, The Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    Wylie J. Dodds M.D.

Authors
  1. Wylie J. Dodds M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dodds, W.J. Clinical and roentgen features of the intestinal polyposis syndromes. Gastrointest Radiol 1, 127–142 (1976). https://doi.org/10.1007/BF02256355

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02256355

Key words

Search

Navigation