Abstract
Naltrindole (NTI) and naltriben (NTB), a benzofuran derivative of NTI, were recently synthesized as highly selective δ-opioid receptor antagonists. Both NTI and NTB failed to suppress the antinociceptive effect induced by morphine. In contrast, both NTI and NTB significantly suppressed the morphine-induced hyperlocomotion and increase in turnover of dopamine (DA) in the mouse limbic forebrain. These results suggest that δ-opioid receptors play, at least in part, a role in the morphine-induced hyperlocomotion and excitation of mesolimbic DA systems, but not antinociception.
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Abbreviations
- β-FNA:
-
β-funaltrexamine hydrochloride
- DA:
-
dopamine
- DOPAC:
-
3,4-dihydroxyphenylacetic acid
- HVA:
-
homovanillic acid
- HPLC-ECD:
-
high-performance liquid chromatography with electrochemical detection
- NTB:
-
naltriben methanesulfonate hydrate
- NTI:
-
naltrindole hydrochloride
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Narita, M., Suzuki, T., Funada, M. et al. Involvement of δ-opioid receptors in the effects of morphine on locomotor activity and the mesolimbic dopaminergic system in mice. Psychopharmacology 111, 423–426 (1993). https://doi.org/10.1007/BF02253531
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DOI: https://doi.org/10.1007/BF02253531