Summary
An anthropometric study was performed in 95 subjects (53 male, 42 female) with Parkinson's disease. Weight, height, triceps and biceps skin-fold thicknesses, and mid-arm circumference were recorded. A high incidence of undernutrition was found (23.6% of males and 22.5% of females, as defined by recent British guidelines). A subgroup of severely disabled patients with Parkinson's disease had a significantly lower mean body mass index than a similarly disabled control group with chronic pyramidal upper motor neuron lesions (males 20.6v 23.2 kg/m2 p<0.05; females 20.6v 26.6 kg/m2 p<0.01), suggesting that the undernutrition is not due to chronic illness or immobility alone. Correlation between anthropometric indices and clinical features of disease demonstrated that the presence of moderate or severe dyskinetic movements was the clinical parameter most strongly related to undernutrition. The reduction in anthropometric indices was most marked for skin fold thickness (related to percentage body fat) and least for arm muscle circumference (related to lean body mass); therefore the weight loss seen in Parkinson's disease is primarily due to fat loss rather than muscle loss.
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References
Abbott R, Markus H, Cox M, Hodkinson M, Tomkins A (1992) Nutritional status of subjects with middle-aged onset Parkinson's disease. Proc Nutrition Soc (in press)
Brouselle E, Borson F, Gonzalez de Suso JM, Chayvialle JA, Beylot M, Chazot G (1991) Augmentation de la depense energetique au cours de la maladie de Parkinson. Rev Neurol (Paris) 147: 46–51
Cox BD, Blaxter M, Buckle ALJ et al (1987) The health and lifestyle survey. Health Promotion Research Trust, London
Durnin JVGA, Womersley J (1974) Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr 32: 77–97
Gregory J, Foster K, Tyler H, Wiseman M (1990) The dietary and nutritional survey of British adults. OPCS, HMSO
Hoehn MM, Yahr MD (1967) Parkinsonism: onset, progression and mortality. Neurology 17: 427–442
Jelliffe DB (1966) The assessment of the nutritional status of the community. World Health Organisation, Geneva (Monograph Ser No 53)
Larsen JP (1991) Parkinson's disease as community health problem: study in Norwegian nursing homes. Br Med J 303: 741–743
Levi S, Cox M, Luan M, Hodkinson M, Tomkins A (1990) Increased energy expenditure in Parkinson's disease. Br Med J 301: 1256–1257
Markus H, Cox M, Tomkins AM (1992) Raised resting energy expenditure in Parkinson's disease and its relationship to muscle rigidity. Clin Sci (in press)
Mena I, Cotzias GC (1975) Protein intake and treatment of Parkinson's disease with levodopa. N Engl J Med 292: 181–184
Parkinson Study Group (1989) DATATOP (Deprenyl and tocopherol antioxidant therapy of Parkinsonism). Arch Neurol 46: 1052–1060
Senarth Yapa RS, Playfer JR, Lye M (1989) Anthropometric and nutritional assessment of elderly patiets with Parkinson's disease. Clin Exp Gerontol 11: 155–164
Tanner C, Goetz D, Klawanas H (1987) Autonomic nervous system disorders. In: Koller W (ed) Handbook of Parkinson's disease. Marcel Dekker, New York, pp 152–169
Vardi J, Oberman Z, Rabey I, Streifler M, Ayalon D, Herzberg M (1976) Weight loss in patients treated long-term with levodopa. J Neurol Sci 30: 33–40
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Markus, H.S., Tomkins, A.M. & Stern, G.M. Increased prevalence of undernutrition in Parkinson's disease and its relationship to clinical disease parameters. J Neural Transm Gen Sect 5, 117–125 (1993). https://doi.org/10.1007/BF02251202
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DOI: https://doi.org/10.1007/BF02251202