Abstract
This study was designed to test whether or not flumazenil (1 mg IV) would change levels of anxiety induced by simulation of public speaking (PSS). Forty normal volunteers were randomly allocated in a parallel groups design to treatment with flumazenil or placebo (double-blind) and one of two stress conditions (PSS/control task). PSS increased anxiety and flumazenil antagonized this effect. The anxiolytic activity of flumazenil was particularly strong on anticipatory anxiety measures. The results were discussed in terms of the involvement of endogenous benzodiazepine-type ligands in the regulation of the human response to stress.
References
Bond AJ, Lader MH (1974) The use of analogous scales in rating subjective feelings. Br J Med Psychol 47:211–218
Curran HV, Birch B (1991) Differentiating the sedative, psychomotor and amnestic effects of benzodiazepines: a study with midazolam and the benzodiazepine antagonist flumazenil. Psychopharmacology 103:519–523
Dollery S (1991) Flumazenil. In: Dollery C (ed) Therapeutic drugs, vol 1. Churchill Livingstone, Edinburgh London Melbourne New York Tokyo Madrid
Guimarães FS, Zuardi AW, Graeff FG (1987) Effect of chlorimipramine and maprotiline on experimental anxiety in humans. J Psychopharmacol 1:184–192
Higgit A, Lader M, Fonagy P (1986) The effects of the benzodiazepine antagonists Ro 15–1788 on psychophysiological performance and subjective measures in normal subjects. Psychopharmacology 89:395–403
Izquierdo I, Medina JH (1991) GABA-A receptor modulation of memory: the role of endogenous benzodiazepines. Trends Neurosci 12:260–265
Lezak (1984) Neuropsychological assessment, 2nd edn. Springer, Berlin
McNair DM, Frankenthaler IM, Czerlinsky T, White TW, Sasson S, Fischer S (1982) Simulated public speaking as a model of clinical anxiety. Psychopharmacology 77:7–10
Medina JH, Novas ML, Wolfman C, Levi de Stein M, De Robertis E (1983) Benzodiazepine receptors in rat cerebral cortex and hippocampus undergo rapid and reversible changes after acute stress. Neuroscience 9:331–335
Nutt D, Lawson C (1992) Panic attacks — a neurochemical overview of models and mechanisms. Br. J Psychiatry 160:165–178
Spielberger CD, Gorsuch RL, Lushene RE (1970) Manual for the state-trait anxiety inventory. Consulting Psychologists Press, Palo Alto, California
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Kapczinski, F., Curran, H.V., Gray, J. et al. Flumazenil has an anxiolytic effect in simulated stress. Psychopharmacology 114, 187–189 (1994). https://doi.org/10.1007/BF02245463
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DOI: https://doi.org/10.1007/BF02245463