References
Albanus L (1970) Central and peripheral effects of anticholinergic compounds. Acta Pharmacol Toxicol 28:305–326
Albanus L, Sundwall A, Winbladh B (1969) Cerebrospinal fluid distribution of methylatropine. Life Sci 8:483–486
Aquilonius SM, Lundholm B, Winbladh B (1972) Effects of some anticholinergic drugs on cortical acetylcholine release and motor activity in rats. Eur J Pharmacol 20:224–230
Ashgar K, Roth LJ (1971) Entry and distribution of hexamethonium in the central nervous system. Biochem Pharmacol 20:2787
Beneviste H, Hüttemeier PC (1990) Microdialysis-theory and application. Prog Neurobiol 35:195–215
Broks P, Preston GC, Traub M, Poppleton P, Ward C, Stahl SM (1988) Modelling dementia: effects of scopolamine on memory and attention. Neuropsychologia 5:685–700
Carlton PL (1962) Some behavioral effects of atropine and methyl atropine. Psychol Rep 10:579–589
Carlton PL, Didamo P (1961) Augmentation of behavioral effects of amphetamine by atropine. J Pharmacol Exp Ther 134:364–376
Dudchenko P, Sarter M (1992) Behavioral microanalysis of spatial delayed alternation performance: rehearsal through overt behavior, and effects of scopolamine and chlordiazepoxide. Psychopharmacology 107:263–270
Elsmore TF, Parkinson JK, Leu JR, Witkin JM (1989) Atropine effects on delayed discrimination performance of rats. Pharmacol Biochem Behav 32:971–975
Hamberger A, Berthold CH, Karlsson B, Lehmann A, Nyström B (1983) Extracellular GABA, glutamate and glutamine in vivo — perfusion-dialysis of the rabbit hippocampus. In: Hertz L, Kvamme E, McGeer EG, Schousboe A (eds) Glutamine, glutamate and GABA in the central nervous system. A. R. Liss, New York, pp 473–492
Harvey JA, Gormezano I, Cool-Hauser VA (1983) Effects of scopolamine and methylscopolamine on classical conditioning of the rabbit nictitating membrane response. J Pharmacol Exp Ther 225:42–49
Innes IR, Nickerson M (1975) Atropine, scopolamine, and related antimuscarinic drugs. In: Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics. Macmillan, New York, pp 514–532
Levine RR (1959) Presence of certain onium compounds in brain tissue following intravenous administration to rats. Nature 184:1412–1414
Levy A, Elsmore TF, Hursh SR (1984) Central vs peripheral anticholinergic effects on repeated acquisition of behavioral chains. Behav Neural Biol 40:1–4
Rodgers RJ, Blanchard DC, Wong LK, Blanchard RJ (1990) Effects of scopolamine on antipredator defense reactions in wild and laboratory rats. Pharmacol Biochem Behav 36:575–583
Sarter M, Dudchenko P, Moore H, Bruno JP (1992) Cognition enhancement based on GABA-cholinergic interactions. In: Butcher LL, Levin E (eds) Neurotransmitter interactions and cognitive function. Birkhäuser, Cambridge (in press)
Schanker LS (1962) Passage of drugs across body membranes. Pharmacol Rev 14:501–530
Szerb JC (1964) The effect of tertiary and quaternary atropine on cortical acetylcholine output and on the electroencephalogram in cats. Can J Physiol Pharmacol 42:303–314
Ungerstedt U (1984) Measurement of neurotransmitter release by intracranial dialysis. In: Marsden CA (ed) Measurement of neurotransmitter release in vivo. John Wiley, New York, pp 81–105
Van Hest A, Stroet J, van Haaren F, Feenstra M (1990) Scopolamine differentially disrupts the behavior of male and female Wistar rats in a delayed nonmatching to position procedure. Pharmacol Biochem Behav 35:903–909
Watanabe H, Shimizu H (1989) Effects of anticholinergic drugs on striatal acetylcholine release and motor activity in freely moving rats studied by microdialysis. Jpn J Pharmacol 51:75–82
Wenger GR (1979) Effects of physostigmine, atropine and scopolamine on behavior maintained by a multiple schedule of food presentation in the mouse. J Pharmacol Exp Ther 209:137–142
Witkin JM, Gordon RK, Chiang PK (1987) Comparison of in vitro actions with behavioral effects of antimuscarinic agents. J Pharmacol Exp Ther 242:796–803
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Moore, H., Dudchenko, P., Comer, K.S. et al. Central versus peripheral effects of muscarinic antagonists: the limitations of quaternary ammonium derivatives. Psychopharmacology 108, 241–243 (1992). https://doi.org/10.1007/BF02245315
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DOI: https://doi.org/10.1007/BF02245315