Abstract
Unlike diazepam, lorazepam has repeatedly been shown to impair perceptual priming as well as explicit memory. To determine whether this deleterious effect was due to an impairment in acquisition of information, 60 healthy volunteers were randomly assigned to five treatment groups (placebo, lorazepam 0.026 or 0.038 mg/kg, diazepam 0.2 or 0.3 mg/kg) and successively performed perceptual priming tasks and a free-recall task. Priming performance on information learned before or 2 h after drug administration, i.e. at the peak concentration of lorazepam, was assessed under the influence of the drugs, using a picture-fragment and a word-stem completion task. Free-recall performance was altered by both drugs. Lorazepam decreased priming performance when information was acquired after, but not before, drug administration, indicating that the drug alters the acquisition of information. Lorazepam also impaired the ability to identify fragmented pictures, but there was no evidence that this perceptual effect accounts for the priming impairment. Surprisingly, diazepam also decreased priming when information was acquired after drug administration, suggesting that, at least in certain circumstances, the two benzodiazepines may exert similar effects on priming measures.
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References
Bond A, Lader M (1974) The use of analogue scales in rating subjective feelings. Br J Med Psychol 47: 211–218
Bonebakker AE, Wolters G (1992) Implicit memory in Korsakoff patients after varying delays. Internat J Psychol 27: 122 (Abstract)
Bonnet C (1989). La perception visuelle des formes. In: Bonnet C, Ghiglione R, Richard JF (eds) Traité de psychologie cognitive, vol 1: perception, action et langage. Dunod, Paris, pp 1–59
Boucart M, Bonnet C (1991) A study of the effect of structural information and familiarity in form perception. Q J Exp Psychol 43A: 223–248
Bowers JS, Schacter DL (1990) Implicit memory and test awareness. J Exp Psychol [Learn Mem Cogn] 16: 404–416
Brown MW, Brown J, Bowes JB (1989) Absence of priming coupled with substantially preserved recognition in lorazepam-induced amnesia. Q J Exp Psychol 41A: 599–617
Brown J, Lewis V, Brown M, Horn G, Bowes JB (1982) A comparison between transient amnesias induced by two drugs (diazepam or lorazepam) and amnesia of organic origin. Neuropsychologia 20: 55–70
Clarke PRF, Eccersley PS, Frisy JP, Thornton JA (1970) The amnesic effect of diazepam (Valium). Br J Anaesth 42: 690–697
Cochran WG, Cox GM (1957) Experimental designs, 2nd edn. Wiley, New York
Content A, Mousty P, Radeau M (1990) Brulex une base de données lexicales informatisée pour le français écrit et parlé. L'Année Psychol 90: 551–566
Curran HV (1991) Benzodiazepines, memory and mood: a review. Psychopharmacology 105: 1–8
Danion JM, Zimmermann MA, Willard-Schroeder D, Grangé D, Singer L (1989) Diazepam induces a dissociation between explicit and implicit memory. Psychopharmacology 99: 238–243
Danion JM, Zimmermann MA, Willard-Schroeder D, Grangé D, Welsch M, Imbs JL, Singer L (1990) Effects of scopolamine, trimipramine and diazepam on explicit memory and repetition priming in healthy volunteers. Psychopharmacology 102: 422–424
Danion JM, Peretti S, Grangé D, Bilik M, Imbs JL, Singer L (1992) Effects of chlorpromazine and lorazepam on explicit memory, repetition priming and cognitive skill learning in healthy volunteers. Psychopharmacology 108: 345–351
Danziger WL, Salthouse TA (1978) Age and the perception of incomplete figures. Exp Aging Res 4: 67–80
Delaney HD, Norman RD, Miller DA (1981) An exploration of the verbal encodability hypothesis for sex differences in the digit-symbol (symbol-digit) test. Intelligence 5: 199–208
Dresp B, Bonnet C (1991) Psychophysical evidence for low level processing of illusory contours and surface in the Kanizsa square. Vision Res 31: 1813–1817
Drouet-Coassolo C, Aubert C, Coassolo P (1989) Capillary gas chromatographic-mass spectrometric method for the identification and quantification of some benzodiazepines and their unconjugated metabolites in plasma. J Chromatogr 487: 295–311
Dundee JW, Mc Gowan WAW, Lilburn JK, McKay AC, Hegarty JE (1979) Comparison of the actions of diazepam and lorazepam. Br J Anaesth 51: 439–446
Fang JC, Hinrichs JV, Ghoneim MM (1987) Diazepam and memory: evidence for spared memory function. Pharmacol Biochem Behav 28: 347–352
Frazier L, Hoyer WJ (1992) Object recognition by component features: are there age differences. Exp Aging Res 18: 9–14
Ghoneim MM, Hinrichs JV, Mewaldt SP (1984) Dose-response analysis of the behavioral effects of diazepam: I. learning and memory. Psychopharmacology 82: 291–295
Ghoneim MM, Mewaldt SP (1977) Studies on human memory: the interactions of diazepam, scopolamine and physostigmine. Psychopharmacology 52: 1–6
Ghoneim MM, Mewaldt SP (1990) Benzodiazepines and human memory: a review. Anesthesiology 72: 926–938
Golombok S, Moodley P, Lader M (1988) Cognitive impairment in long-term benzodiazepine users. Psychol Med 18: 365–374
Gottschaldt K (1928) Uber den Einfluss der Erfahrung auf die Wahrnehmung von figuren. Psychol Forsch 8: 18–317
Graf P, Mandler G, Haden PE (1982) Simulating amnesic symptoms in normal subjects. Science 218: 1243–1244
Graf P, Schacter DL (1985) Implicit and explicit memory for new associations in normal and amnesic subjects. J Exp Psychol [Learn Mem Cogn] 11: 501–518
Greenblatt DJ (1981) Clinical pharmacokinetics of oxazepam and lorazepam. Clin Pharmacokinet 6: 89–105
Guentert TW (1984) Pharmacokinetics of benzodiazepines and of their metabolites. In: Bridges JW, Chasseaud LF (eds) Progress in drug metabolism, vol 8. Taylor and Francis, Bakingstoke, UK, pp 241–375
Jacoby LL (1991) A process dissociation framework: separating automatic from intentional uses of memory. J Mem Lang 30: 513–541
Jacoby LL, Toth JP, Yonelinas AP (1993) Separating conscious and unconscious influences of memory: measuring recollection. J Exp Psychol [Gen] 122: 139–154
Jolley ME (1981) Fluorescence polarization immunoassay for the determination of therapeutic drugs levels in human plasma. J Anal Toxicol 5: 236–240
Kihlstrom JF, Schacter DL, Cork RC, Hurt CA, Behr SE (1990) Implicit and explicit memory following surgical anesthesia. Psychol Sci 1: 303–306
Knopman D (1991) Unaware learning versus preserved learning in pharmacologic amnesia: similarities and differences. J Exp Psychol [Learn Mem Cogn] 17: 1017–1029
Kothary SP, Brown ACD, Pandit UA, Samra SK, Pandit SK (1981) Time course of antirecall effect of diazepam and lorazepam following oral administration. Anesthesiology 55: 641–644
Lister R (1985) The amnesic action of benzodiazepines in man. Neurosci Biobehav Rev 9: 87–94
Lister R (1991) The effects of benzodiazepines and 5-HT1A agonists on learning and memory. In: Rodgers RJ, Cooper SJ (eds) 5-HT1A agonists, 5-HT3 antagonists and benzodiazepines: their comparative behavioral pharmacology. Wiley, Chichester, pp 267–280
Lister RG, File SE (1984) The nature of lorazepam-induced amnesia. Psychopharmacology 83: 183–187
Mandelli M, Tognoni G, Garattini S (1978) Clinical pharmacokinetics of diazepam. Clin Pharmacokinet 3: 72–91
Marr D (1982) Vision: a computational investigation into the human representation and processing of visual information. Freeman, San Francisco
Read DE (1988) Age-related changes in performance on a visualclosure task. J Clin Exp Neuropsychol 10: 451–466
Royer FL (1971) Information processing of visual figures in the digit symbol substitution task. J Exp Psychol 87: 335–342
Russo R, Parkin AJ (1993) Age differences in implicit memory: more apparent than real. Mem Cogn 21: 73–80
Sellal F, Danion JM, Kauffmann-Muller F, Grangé D, Imbs JL, Van Der Linden M, Singer L (1992) Differential effects of diazepam and lorazepam on repetition priming in healthy volunteers. Psychopharmacology 108: 371–379
Snodgrass JG, Smith B, Feenan K, Corwin J (1987) Fragmenting pictures on the Apple Macintosh computer for experimental and clinical applications. Behav Res Methods Instrum Comput 19: 270–274
Snodgrass JG, Corwin J (1988) Perceptual identification thresholds for 150 fragmented pictures from the Snodgrass and Vanderwart picture set. Percept Mot Skills 67: 3–36
Snodgrass JG, Surprenant A (1989) Effect of retention interval on implicit and explicit memory for pictures. Bull Psychon Soc 27: 395–398
Squire LR, Ojemann JG, Miezin FM, Petersen SE, Videen TO, Raichle ME (1992) Activation of the hippocampus in normal humans: a functional anatomical study of memory. Proc Natl Acad Sci USA 89: 1837–1841
Taylor JL, Tinklenberg JR (1987) Cognitive impairment and benzodiazepines. In: Meltzer HY (ed) Psychopharmacology: the third generation of progress. Raven Press, New York, pp 1449–1454
Tulving E, Schacter DL (1990) Priming and human memory systems. Science 247: 301–306
Van Der Linden M, Coyette F, Prairial C (1992) Le priming perceptif chez le patient amnésique. Acta Neurol Belg 92: 173–174 (Abstract)
Von Der Heydt R, Peterhans E (1989) Mechanisms of contour perception in monkey visual cortex 1. Lines of pattern discontinuities. J Neurosci 9: 1731–1748
Warrington EK, Weiskrantz L (1968) New method of testing long-term retention with special reference to amnesic patients. Nature 217: 972–974
Wechsler Adult Intelligence Scale — Revised (1981) The Psychological Corporation, New York. Traduction et adaptation françaises (1989). Les Editions du Centre de Psychologie Appliquée, Paris
Zucker SW, Davis S (1988) Points and endpoints: a size/spacing constraint for dot grouping. Perception 17: 229–247
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Vidailhet, P., Danion, JM., Kauffmann-Muller, F. et al. Lorazepam and diazepam effects on memory acquisition in priming tasks. Psychopharmacology 115, 397–406 (1994). https://doi.org/10.1007/BF02245083
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DOI: https://doi.org/10.1007/BF02245083