Abstract
Rats were trained to respond under a response duration differentiation schedule in which responses on a lever were reinforced if lever press durations were greater than or equal to 1.00 s but were also less than 1.30 s. Dose-effect curves were generated for cocaine, methamphetamine, pentobarbital, phencyclidine, delta-9-tetrahydrocanninabol (Δ9-THC), and morphine. All drugs produced dose-dependent decreases in accuracy (the percentage of total response durations that were reinforced); however, the degree to which changes in accuracy were accompanied by changes in response rates varied among drugs. Pentobarbital and morphine affected primarily longer (> 1.3 s) response durations, phencyclidine and Δ9-THC affected primarily shorter response durations, whereas cocaine and methamphetamine affected both shorter and longer response durations. High doses of methamphetamine and cocaine increased the dispersion of response duration distributions with increasing dose, whereas higher doses of pentobarbital, Δ9-THC and morphine did not increase dispersion of response duration distributions as much. These data show that behavior under this novel schedule is differentially sensitive to a number of pharmacologic manipulations, and that the schedule can provide a useful addition to the analysis of drug effects upon behavior.
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References
Adam-Carriere DA, Merali Z, Stretch R (1978) Effects of morphine, naloxone,d,l-cyclazocine, andd-amphetamine on behavior controlled by a schedule of interresponse time reinforcement. Can J Physiol Pharmacol 56:707–720
Ando K (1975) Profile of drug effects on temporally spaced responding in rats. Pharmacol Biochem Behav 3:833–841
Balste, RL, Baird JB (1979) Effects of phencyclidine,d-amphetamine and pentobarbital on spaced responding in mice. Pharmacol Biochem Behav 11:617–623
Brocco MJ, Rastogi SK, McMillan DE (1984) Effects of chronic phencyclidine administration on the schedule-controlled behavior of rats. J Pharmacol Exp Ther 226:449–454
Campbell JC, Seiden LS (1973) Performance influence on the development of tolerance to amphetamine. Pharmacol Biochem Behav 1:703–708
Conrad DC, Elsmore TF, Sodetz FJ (1972) Delta-9-tetrahydrocannabinol dose-related effects on timing behavior in chimpanzees. Science 175:547–550
Falk JL (1969) Drug effects on discriminative motor control. Physiol Behav 4:421–427
Ferraro DP, Grilly DM (1970) Response differentiation: a psychophysical method for response produced stimuli. Percept Psychophysiol 7:206–208
Ferraro DP, Grilly DM, Tang RSW (1968) Transfer of a differentiation along a response continuum. J Comp Physiol Psychol 66:793–796
Fischman MW, Schuster CR (1977) Long-term behavioral changes in the rhesus monkey after multiple daily injections ofd-methylamphetamine. J Pharmacol Exp Ther 201:593–605
Ford RD, Balster RL (1976) Schedule-controlled behavior in the morphine-dependent rat. Pharmacol Biochem Behav 4:569–573
Fowler SC (1987) Force and duration of operant response as dependent variables in behavioral pharmacology. In: Thompson, T, Dews PB, Barrett JE (eds) Advances in behavioral pharmacology vol 6: neurobehavioral pharmacology. Lawrence Erlbaum, Hillsdale, N.J., pp 83–127
Fowler SC, Filewich RJ, Leberer MR (1977) Within-response force variations accompanying duration differentiation in rats. Psychol Rep 40:1271–1284
Fowler SC, Ford KE, Gramling SE, Nail GL (1984) Acute and subchronic effects of neuroleptics on quantitative measures of discriminative motor control in rats. Psychopharmacology 84:368–373
Freeman AS, Martin BR, Balster RL (1984) Relationship between the development of behavioral tolerance and the biodisposition of phencyclidine in mice. Pharmacol Biochem Behav 20:373–377
Hudzik TJ, Slifer BL (1992) Interaction of sigma and pep-like drugs on operant behaviors in the rat. Psychopharmacology 108:115–122
Johanson CE, Aigner TG, Seiden LS, Schuster CR (1979) The effects of methamphetamine on fine motor control in rhesus monkeys. Pharmacol Biochem Behav 11:273–278
Logan L, Carney JM, Holloway FA, Seale TW (1989) Effects of caffeine, cocaine and their combination on fixed-interval behavior in rats. Pharmacol Biochem Behav 33:99–104
McMillan DE, Campbell RJ (1970) Effects ofd-amphetamine an chlordiazepoxide on spaced responding in pigeons. J Exp Anal Behav 14:177–184
McMillan DE, Patton RA (1965) Differentiation of a precise timing response. J Exp Anal Behav 8:219–226
Notterman JM, Mintz DE (1965) Dynamics of response. Wiley, New York
Pradhan SN, Bailey PT, Ghosh P (1972) Effects of delta-9-tetrahydrocannibinol on timing behavior in rats. Psychon Sci 27:179–181
Preston KL, Schuster CR, Seiden LS (1985) Methamphetamine, physostigmine, atropine and mecamylamine: effects on force lever performance. Pharmacol Biochem Behav 23:781–788
Sanger DJ, Jackson AJ (1989) Effects of phencyclidine and othern-methyl-d-aspartate antagonists on the schedule-controlled behavior of rats. J Pharmacol Exp Ther 248:1215–1219
Schulze GE, Paule MG (1990) Acute effects ofd-amphetamine in a monkey operant behavioral test battery. Pharmacol Biochem Behav 35:759–765
Schulze GE, Paule MG (1991) Effects of morphine sulfate on operant behavior in rhesus monkeys. Pharmacol Biochem Behav 38:77–83
Schulze GE, McMillan DE, Bailey JR, Scallet A, Ali SF, Slikker W, Paule MG (1988) Acute effects of delta-9-tetrahydrocannabinol in rhesus monkeys as measured by performance in a battery of complex operant tests. J Pharmacol Exp Ther 245:178–186
Schulze GE, Slikker W, Paule MG (1989) Multiple behavioral effects of diazepam in rhesus monkeys. Pharmacol Biochem Behav 34:29–35
Stubbs DA, Thomas JR (1974) Discrimination of stimulus duration andd-amphetamine in pigeons: a psychophysical analysis. Psychopharmacologia 36:313–322
Wenger GR, Wright DW (1990) Behavioral effects of cocaine and its interaction withd-amphetamine and morphine in rats. Pharmacol Biochem Behav 35:595–600
Woolverton WL, Kandel D, Schuster CR (1978) Effects of repeated administration of cocaine on schedule-controlled behavior of rats. Pharmacol Biochem Behav 9:327–337
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Hudzik, T.J., McMillan, D.E. Drug effects on response duration differentiation I: differential effects of drugs of abuse. Psychopharmacology 114, 620–627 (1994). https://doi.org/10.1007/BF02244993
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DOI: https://doi.org/10.1007/BF02244993