Abstract
Concentric dialysis probes were vertically implanted in rats in the nucleus accumbens (Acc) of one side and in the dorsal caudate-putamen (CPu) of the other side. On the day after the implant the output of dopamine was monitored and the changes elicited byd-amphetamine sulphate were compared in the two areas. Amphetamine preferentially stimulated dopamine release in the Acc in a wide range of doses (0.25, 0.5, 1.0, 2.0 mg/kg SC) when Acc probes were located in the medial aspect of the Acc. In contrast, no significant differences between the Acc and the dorsal CPu were obtained in response to amphetamine (0.5 mg/kg SC) when Acc probes were located about 0.7 mm lateral to the previous site. It is concluded that the preferential effect of amphetamine in the Acc is related to precise topographical boundaries. This in turn might be related to the existence of a sharp anatomical and functional heterogeneity within the Acc.
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References
Alheid GF, Heimer L (1988) New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders; the striatopallidal, amygdaloid, and corticopetal components of substantia innominata. Neuroscience 27:1–39
Amberg G, Lindefors N (1989) Intracerebral microdialysis: II. Mathematical studies of diffusion kinetics. J Pharmacol Methods 22:157–183
Benveniste H, Hansen AJ, Ottosen NS (1989) Determination of brain interstitial concentrations by microdialysis. J Neurochem 52:1741–1750
Brazell MP, Mitchell SN, Joseph MH, Gray JA (1990) Acute administration of nicotine increases the in vivo extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid and ascorbic acid preferentially in the nucleus accumbens of the rat: comparison with caudate-putamen. Neuropharmacology 29:1177–1185
Carboni E, Imperato A, Perezzani L, Di Chiara G (1989) Amphetamine, cocaine, phencyclidine and nomifensine increase extracellular dopamine concentrations preferentially in nucleus accumbens of freely moving rats. Neuroscience 28:653–661
Di Chiara G (1991) On the preferential release of mesolimbic dopamine by amphetamine. Neuropsychopharmacology 5:243–244
Di Chiara G, Imperato A (1988b) Opposite effects of μ andκ-opiate agonists on dopamine-release in the nucleus accumbens and in the dorsal caudate of freely moving rats. J Pharmacol Exp Ther 244:1067–1080
Di Chiara G, Imperato A (1988a) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci 85:5274–5278
Everitt BJ, Cador M, Robbins TW (1989) Interactions between the amygdala and ventral striatum in stimulus-reward associations: studies using a second-order schedule of sexual reinforcement. Neuroscience 30:63–75
Gerfen CR, Baimbridge KG, Miller JJ (1985) The neostriatal mosaic: comportamental distribution of calcium-binding protein and parvalbumin in the basal ganglia of the rat and monkey. Proc Natl Acad Sci 82:8780–8784
Heimer L, Zahm DS, Churchill L, Kalivas PW, Wohltmann C (1991a) Specificity in the projection patterns of accumbal core and shell in the rat. Neuroscience 41:89–125
Heimer L, de Olmos JS, Alheid GF, Zaborszky L (1991b) Perestroika in basal forebrain; opening the borders between neurology and psychiatry. Prog Brain Res 87:109–169
Hsiao JK, Ball BA, Morrison PF (1990) Effects of different semipermeable membranes on in vitro and in vivo performance of microdialysis probes. J Neurochem 54:1449–1452
Imperato A, Di Chiara G (1986) Preferential stimulation of dopamine-release in the nucleus accumbens of freely moving rats by ethanol. J Pharmacol Exp Ther 239:219–228
Imperato A, Mulas A, Di Chiara G (1986) Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats. Eur J Pharmacol 132:337–338
Kuczenski R, Segal DS (1992) Differential effects of amphetamine and dopamine uptake blockers (Cocaine, Nomifensine) on caudate and accumbens dialysate dopamine and 3-methoxytyramine. J Pharmacol Exp Ther 262:1085–1094
Kuczenski R, Segal DS, Aizenstein ML (1991) Amphetamine, fencamfamine and cocaine: Relationships between locomotor and stereotypy response profiles and caudate and accumbens dopamine dynamics. J Neurosci 11:2703–2712
Paxinos G, Watson C (1987) The rat brain in stereotaxic coordinates. Academic Press, Sydney
Pehek EA, Schechter MD, Yamamoto BK (1990) Effects of cathinone and amphetamine on the neurochemistry of dopamine in vivo. Neuropharmacology 29:1171–1176
Robinson TE, Camp DM (1990) Does amphetamine preferentially increase the extracellular concentration of dopamine in the mesolimbic system of freely moving rats? Neuropsychopharmacology 3:163–173
Segal DS, Kuczenski R (1992) Repeated cocaine administration induces behavioral sensitization and corresponding decreased extracellular dopamine responses in caudate and accumbens. Brain Res 577:351–355
Sharp T, Zetterstrom T, Ljungberg T, Ungerstedt U (1987) A direct comparison of amphetamine-induced behaviours and regional brain dopamine release in the rat using intracerebral dialysis. Brain Res 401:322–330
Westerink BHC, Tuntler J, Damsma G, Rollema H, De Vries JB (1987) The use of tetrodotoxin for the characterization of drug-enhanced dopamine release in conscious rats studied by brain dialysis. Naunyn-Schmiedeberg's Arch Pharmacol 336:502–507
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Di Chiara, G., Tanda, G., Frau, R. et al. On the preferential release of dopamine in the nucleus accumbens by amphetamine: further evidence obtained by vertically implanted concentric dialysis probes. Psychopharmacology 112, 398–402 (1993). https://doi.org/10.1007/BF02244939
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DOI: https://doi.org/10.1007/BF02244939