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The kappa-opioid U-50,488H suppresses the initiation of nocturnal spontaneous drinking in normally hydrated rats

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Abstract

The effect of a systemic (IP) treatment with 1.0, 3.0 and 9.0 mg/kg U-50,488H (U50), a highly selective kappa-agonist, on spontaneous, nocturnal ingestive behavior of the rat was studied using a microcomputer controlled data acquisition system. The latency to initiate drinking was increased and drinking behavior was suppressed in the first hour after injection in a dose-dependent manner. The consummatory indices of drinking were not affected. After this period of adipsia, a phase of polydipsia, that was probably due to the diuretic effect of U50, was evident. The prophagic effect of U50 was evident only at the dose of 3 mg/kg and was accompanied by an increased duration of feeding episodes but not by a reduced latency to feed. These results suggest that kappa-receptors play a pivotal role in modulating spontaneous drinking in the normally hydrated rat and that this control is mainly exerted on the motivational aspect of drinking.

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  1. Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, H3G 1M8, Montréal, Québec, Canada

    Aldo Badiani & Jane Stewart

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  1. Aldo Badiani
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  2. Jane Stewart
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Badiani, A., Stewart, J. The kappa-opioid U-50,488H suppresses the initiation of nocturnal spontaneous drinking in normally hydrated rats. Psychopharmacology 106, 463–473 (1992). https://doi.org/10.1007/BF02244816

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  • DOI: https://doi.org/10.1007/BF02244816

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