Abstract
Rats exposed to a context previously paired with an inescapable shock session showed an increase in the paw lick and escape latencies in the hotplate test. This analgesic response was clearly reversed following chronic antidepressant drug administration. These findings indicate that chronic antidepressant treatment can influence the biological processes involved in the inescapable shock-induced conditioned analgesia
This is a preview of subscription content, log in via an institution to check access.
References
Amir S, Amit Z (1978) Endogenous opiate ligands may mediate stress-induced changes in the affective properties of pain related behavior in rats. Life Sci 23:1143–1152
Amit Z, Galina H (1986) Stress-induced analgesia: adaptive pain suppression. Physiol Rev 66:1091–1120
Antkiewicz-Michaluk L, Rokosz-Pelc A, Vetulani J (1984) Increase in rat cortical [3H] naloxone binding site density after chronic administration of antidepressant agents. Eur J Pharmacol 102:179–181
Bolles RC, Fanselow MS (1980) A perceptual-defensive-recuperative model of fear and pain. Behav Brain Sci 3:291–301
Eschalier A, Montastruc JL, Devoize JL, Rigal F, Gaillard-Plaza G, Pechadre JC (1981) Influence of naloxone and methysergide on the analgesic effect of clomipramine in rats. Eur J Pharmacol 74:1–7
Malseed RT, Goldstein FJ (1979) Enhancement of morphine analgesia by tricyclic antidepressant. Neuropharmacology 18:827–829
Murua VS, Molina VA (1990) An opiate mechanism involved in conditioned analgesia influences forced swim-induced immobility. Physiol Behav 48:641–645
Porsolt RD, Anton G, Blavet N, Jalfre M (1978) Behavioral despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 47:379–391
Rang HP, Dale MM (1987) Pharmacology. Churchill Livingston, Edinburgh London Melbourne New York
Reisine T, Soubrie P (1982) Loss of rat cerebral cortical opiate receptors following chronic desipramine treatment. Eur J Pharmacol 77:39–44
Rigal F, Eschalier A, Devoize JL, Pechadre JC (1983) Activities of five antidepressants in a behavioral pain test in rats. Life Sci 32:2965–2971
Roth KA, Katz RJ (1981) Further studies on a novel animal model of depression: therapeutic effects of a tricyclic antidepressant. Neurosci Biobehav Rev 5:253–258
Sulser F (1979) New perspectives on the mode of action of anti-depressant drug. TIPS 1:92–94
Author information
Authors and Affiliations
Additional information
Fellowship from CONICET
Rights and permissions
About this article
Cite this article
Murua, V.S., Molina, V.A. Chronic antidepressant counteracts the conditioned analgesia induced by a context previously associated with inescapable shock. Psychopharmacology 105, 439–441 (1991). https://doi.org/10.1007/BF02244442
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02244442