Abstract
The effect of lithium administration (800 mg daily for 7 days) on the neuroendocrine and temperature responses to the 5-HT1A receptor agonist, gepirone, was studied in eight healthy male volunteers. Gepirone (20 mg orally) significantly increased plasma levels of prolactin, growth hormone, corticotropin and cortisol, and lowered oral temperature. None of these responses was significantly altered by lithium treatment. The results suggest that the ability of short-term lithium treatment to increase 5-HT-mediated neuroendocrine responses in humans is unlikely to be related to changes in the sensitivity of pre- or post-synaptic 5-HT1A receptors.
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References
Anderson IM, Cowen PJ, Grahame-Smith DG (1990) The effects of gepirone on neuroendocrine function and temperature in humans. Psychopharmacology 100:498–503
Blier P, De Montigny C (1985) Short-term lithium administration enhances serotonergic neurotransmission: electrophysiological evidence in the rat CNS. Eur J Pharmacol 113:69–77
Blier P, De Montigny C, Tardif D (1987) Short-term lithium treatment enhances responsiveness of post-synaptic 5-HT1A receptors without altering 5-HT autoreceptor sensitivity: an electrophysiological study in the rat brain. Synapse 1:225–232
Cowen PJ, McCance SL, Cohen PR, Julier DL (1989) Lithium increases 5-HT-mediated neuroendocrine responses in tricyclic resistant depression. Psychopharmacology 99:230–232
Cowen PJ, Cohen PR, McCance SL, Friston KJ (1990a) 5-HT neuroendocrine responses during psychotropic drug treatment: an investigation of the effects of lithium. J Neurosci Methods 34:201–205
Cowen PJ, Anderson IM, Grahame-Smith DG (1990b) Neuroendocrine effects of azapirones. J Clin Psychopharmacol 10 [3]:21–25
Eison MS, Yevich JP, Farney RF (1985) Gepirone hydrochloride. Drugs of the Future 10:450–457
Friedman E, Wang HY (1988) Effect of chronic lithium treatment on 5-hydroxytryptamine autoreceptors and release of 5-[3H]hydroxytryptamine from rat brain cortical, hippocampal and hypothalamic slices. J Neurochem 50 [1]:195–201
Gilbert F, Brazell C, Tricklebank MD, Stahl SM (1988) Activation of the 5-HT1A receptor subtype increases rat ACTH concentration. Eur J Pharmacol 147:431–439
Glue PW, Cowen PJ, Nutt DJ, Kolakowska T, Grahame-Smith DG (1986) The effect of lithium on 5-HT-mediated neuroendocrine responses and platelet 5-HT receptors. Psychopharmacology 90:398–402
Goodwin GM, De Souza RJ, Green AR (1985) The pharmacology of the hypothermic response in mice to 8-hydroxy-2-(di-n-propylamine)tetralin (8-OH-DPAT). Neuropharmacology 24:1187–1194
Goodwin GM, De Souza RJ, Wood AJ, Green AR (1986a) The enhancement by lithium of the 5-HT1A-mediated serotonin syndrome produced by 8-OH-DPAT in the rat. Psychopharmacology 90:488–493
Goodwin GM, De Souza RJ, Wood AJ, Green AR (1986b) Lithium decreases 5-HT1A and 5-HT2 and α2-adrenoceptor mediated function in mice. Psychopharmacology 90:482–487
Grahame-Smith DG, Green AR (1974) The role of brain 5-hydroxytryptamine in the hyperactivity produced in rats by lithium and monoamine oxidase inhibitors. Br J Pharmacol 52:19–26
Green AR, Goodwin GM (1987) The pharmacology of the hypothermic response of rodents to 8-OH-DPAT administration and the effects of psychotropic drug treatment on this response. In: Dourish CT, Hutson PH, Ahlenius S (eds) Brain 5-HT1A receptors. Ellis Horwood, Chichester, pp 161–176
Koenig JI, Gudelsky GA, Meltzer HY (1987) Stimulation of corticosterone and β-endorphin secretion in the rat by selective 5-HT receptor subtype activation. Eur J Pharmacol 137:1–8
Koenig JI, Meltzer HY, Gudelsky GA (1988) 5-hydroxytryptamine1A receptor mediated effects of buspirone, gepirone and ipsapirone. Pharmacol Biochem Behav 29:711–715
McCance SL, Cohen PR, Cowen PJ (1989) Lithium increases 5-HT-mediated prolactin release. Psychopharmacology 99:276–281
Mizuta T, Segawa T (1988) Chronic effects of imipramine and lithium on post-synaptic 5-HT1A and 5-HT1B sites and on pre-synaptic 5-HT3 sites in the rat brain. J Pharmacol 47:107–113
Nash JF, Meltzer HY (1989) Effect of gepirone and ipsapirone on the stimulated and unstimulated secretion of prolactin in the rat. J Pharmacol Exp Ther 249:236–241
Peroutka SJ (1985) Selective interaction of novel anxiolytics with 5-hydroxytryptamine1A receptors. Biol Psychiatry 20:971–979
Price LH, Charney DS, Delgado PL, Heninger GR (1989) Lithium treatment and serotonergic function: neuroendocrine and behavioural responses to intravenous tryptophan in affective disorder. Arch Gen Psychiatry 46:13–19
Price LH, Charney DS, Delgado PL, Heninger GR (1990) Lithium and serotonin function: implications for the serotonin hypothesis of depression. Psychopharmacology 100:3–12
Smith CE, Ware CJ, Cowen PJ (1991) Pindolol decreases prolactin and growth hormone responses to intravenousl-tryptophan. Psychopharmacology 103:140–142
Treiser SL, Cascio CS, O'Donahue TL, Thoa NB, Jacobowitz DM, Kellar KJ (1981) Lithium increases serotonin release and decreases serotonin receptors in hippocampus. Science 213:1529–1531
Tricklebank MD, Forler C, Gozard JR (1984) The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamine)tetralin. Eur J Pharmacol 106:271–282
Wood AJ, Goodwin GM (1987) A review of the biochemical and neuropharmacological actions of lithium. Psychol Med 17:579–600
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Walsh, A.E., Ware, C.J. & Cowen, P.J. Lithium and 5-HT1A receptor sensitivity: a neuroendocrine study in healthy volunteers. Psychopharmacology 105, 568–572 (1991). https://doi.org/10.1007/BF02244382
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DOI: https://doi.org/10.1007/BF02244382