Abstract
Sleep was recorded in the diurnal rodentEutamias sibiricus, chronically implanted with EEG and EMG electrodes. The tricyclic antidepressant drug clomipramine suppressed the duration of REM sleep and EEG power density in the frequencies between 1.5 and 13.5 Hz in nonREM sleep. During the administration of clomipramine, 24 h of sleep deprivation by forced locomotion significantly reduced the duration of waking and increased the duration of nonREM sleep. During the first 2 h of recovery sleep, EEG power density of the frequencies between 2.5 and 6 Hz was enhanced. These effects of sleep deprivation were to a large extent similar to those of sleep deprivation under drug free conditions. It is concluded that clomipramine affects the EEG in nonREM sleep but does not interfere substantially with nonREM sleep regulatory processes, which are activated by sleep deprivation.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Beersma DGM, Dijk DJ, Blok CGH, Everhardus I (1990) REM sleep deprivation during 5 hours leads to an immediate REM sleep rebound and to suppression of NREM sleep intensity. Electroencephalogr Clin Neurophysiol 76:114–122
Borbély AA, Neuhaus HU (1979) Sleep deprivation: effects on sleep and EEG in the rat. J Comp Physiol 133:71–87
Borbély AA, Wirz-Justice A (1982) Sleep, sleep deprivation and depression — a hypothesis derived from a model of sleep regulation. Hum Neurobiol 1:205–210
Borbély AA, Baumann F, Brandeis D, Strauch I, Lehmann D (1981) Sleep deprivation: effect on sleep stages and EEG power density in man. Electroencephalogr Clin Neurophysiol 51:483–493
Borbély AA, Tobler I, Hanagasioglu M (1984) Effect of sleep deprivation on sleep and EEG power spectra in the rat. Behav Brain Res 14:171–182
Dijk DJ, Daan S (1989) Sleep EEG spectral analysis in a diurnal rodent:Eutamias sibiricus. J Comp Physiol (A) 165:205–215
Dunleavy DLF, Brezinova V, Oswald I, Maclean AW, Tinker M (1972) Changes during weeks in effects of tricyclic drugs on the human sleeping brain. Br J Psychiatry 120:663–672
Grahnstedt S, Ursin R (1985) Platform sleep deprivation affects deep slow wave sleep in addition to REM sleep. Behav Brain Res 18:233–239
Hartmann E (1968) Amitriptyline and imipramine: effects on human sleep. Psychophysiology 5:207
Khazan H, Brown P (1970) Differential effects of three tricyclic antidepressants on sleep and REM sleep in the rat. Life Sci 9:279–284
Oswald I (1973) Sleep studies with clomipramine (Anafranil) and related drugs. J Int Med Res 1:296–298
Rabiner LR, Gold B (1975) Theory and application of digital signal processing. Prentice Hall, Englewoods Cliffs, New Jersey
Tobler I, Jaggi K (1987) Sleep and EEG spectra in the Syrian hamster(Mesocricetus auratus) under baseline conditions and following sleep deprivation. J Comp Physiol (A) 161:449–459
Trachsel L, Tobler I, Borbély AA (1986) Sleep regulation in rats: effects of sleep deprivation, light and circadian phase. Am J Physiol 251:R1037-R1044
Vogel GW, Vogel F, McAbee RS, Thurmond AJ (1980) Improvement of depression by REM sleep deprivation. New findings and a theory. Arch Gen Psychiatry 37:247–253
Ware JC, Brown FW, Moorad PJ, Pittard JT, Cobert B (1989) Effects on sleep: a double-blind study comparing trimipramine to imipramine in depressed insomniac patients. Sleep 12:537–549
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dijk, D.J., Strijkstra, A., Daan, S. et al. Effect of clomipramine on sleep and EEG power spectra in the diurnal rodentEutamias sibiricus . Psychopharmacology 103, 375–379 (1991). https://doi.org/10.1007/BF02244292
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02244292