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Etiology of peptic ulcer

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References

  1. Rivers, A. B. Peptic ulcer. InCyclopedia of Medicine, Surgery and Specialties. Philadelphia, Davis, 1939, vol. 13, p. 340.

    Google Scholar 

  2. Hollander, F., The two-component mucous barrier. Its activity in protecting the gastroduodenal mucosa against peptic ulceration.A.M.A. Arch. Int. Med. 93:107, 1954.

    Google Scholar 

  3. Slive, A., Bachrach, W. H., andFogelson, S. J. The significance of nutrition and gastric acidity in the etiology of experimental peptic ulcer.Surg., Gynec., & Obst. 70:666, 1940.

    Google Scholar 

  4. Weech, A. A., andPaige, B. H. Nutritional edema in the dog. IV. Peptic ulcer produced by the same low protein diet that leads to hypoproteinemia and edema.Am. J. Path. 13:249, 1937.

    Google Scholar 

  5. Haelzel, F., andDaCosta, E. Production of ulcers in the prostomach of rats by protein restriction.Proc. Soc. Exper. Biol. & Med. 29:382, 1931–32.

    Google Scholar 

  6. Haelzel, F., andDaCosta, E. Production of peptic ulcers in rats and mice by diets deficient in protein.Am. J. Digest. Dis. 4:325, 1937.

    Google Scholar 

  7. Shay, H., Gruenstein, M., Siplet, H., andKomarov, S. A. Protection of gastric mucosa of the rat against ulceration by prefeeding with protein hydrolysates.Proc. Soc. Exper. Biol. & Med. 69:369, 1948.

    Google Scholar 

  8. Virchow, R. Historiches, Kritisches und Positives zur Lehre der Unterleibsaffektonen.Virchows Arch. 5:5281, 1856.

    Google Scholar 

  9. Baronofsky, I., Merendino, K. A., Bratrud, T. E., andWangensteen, O. H. Fate of intravenously injected fat: Its role in the production of ulcer.Proc. Soc. Exper. Biol. & Med. 59:231, 1945.

    Google Scholar 

  10. Friedman, G. A. The experimental production of lesions, erosions and acute ulcers in the duodenal mucosa of dogs by repeated injections of epinephrine.J. Med. Res. 32:95, 1951.

    Google Scholar 

  11. Penner, A., andBernheim, A. L. Experimental production of digestive tract ulcerations.J. Exper. Med. 70:453, 1939.

    Google Scholar 

  12. Nedzel, A. J. Experimental gastric ulcer (Pitressin episodes).Arch. Path. 29:988, 1938.

    Google Scholar 

  13. Hedinger, S., andVeraguth, F. Magengeschwuere bei Ratten unter Behandlung mit 5-Hydroxytrayptamin.Schweiz. Med. Wchnshr. 87:1175, 1957.

    Google Scholar 

  14. Haverback, B. J., andBogdanski, D. F. Gastric mucosal erosion in the rat following administration of serotonin precursor 5-hydroxytryptophan.Proc. Soc. Exper. Biol. & Med. 95:392, 1957.

    Google Scholar 

  15. Shay, H., Sun, D. C. H., andGruenstein, M. The action of psychopharmacologic agents on interdigestive gastric secretion in the rat.Proc. World Congress of Gastroenterology. Baltimore, Md., Williams & Wilkins, Baltimore, 1:108, 1959.

    Google Scholar 

  16. MacDonald, R. A. Study of 356 carcinoids of gastrointestinal tract.Am. J. Med. 21:867, 1956.

    Google Scholar 

  17. Wilhelmj, C. M., O'Brien, F. T., andHill, F. C. Improved gastric test meal and study of secretory curve in whole stomach pouches and in normal intact stomach.Am. J. Physiol. 115:5, 1936.

    Google Scholar 

  18. Woodward, E. R., Lyon, E. S., Landor, J., andDragstedt, L. R. The physiology of the gastric antrum: Experimental studies on isolated antrum pouches in dogs.Gastroenterology 27:766, 1954.

    Google Scholar 

  19. Shay, H., Gershon-Cohen, J., andFels, S. S. Self-regulatory duodenal mechanism for gastric acid control and explanation for pathologic gastric physiology in uncomplicated duodenal ulcer.Am. J. Digest. Dis. 9:124, 1942.

    Google Scholar 

  20. Shay, H., Gershon-Cohen, J., andFels, S. S. Role of upper small intestine in control of gastric secretion. Effect of neutral fat, fatty acid and soaps; phase of gastric secretion influenced and relative importance of psychic and chemical phases.Ann. Int. Med. 13:294, 1939.

    Google Scholar 

  21. Shay, H., andGershon-Cohen, J. Experimental studies in gastric physiology in man. II. A study of pyloric control: The roles of acid and alkali.Surg., Gynec. & Obst. 58:935, 1934.

    Google Scholar 

  22. Lorber, S., andShay, H. The duodenal mechanism in the control of gastric motility. Intraluminal gastric and duodenal pressure studies.Gastroenterology 31:117, 1956.

    Google Scholar 

  23. Palmer, W. L., andNutter, P. B. Peptic ulcer and achlorhydria. A further study of the role of acid gastric juice in the pathogenesis of peptic ulcer.Arch. Int. Med. 65:499, 1940.

    Google Scholar 

  24. Shay, H., Komarov, S. A., andBerk, J. E. Some fallacies in the clinical measurement of gastric -acidity with special reference to the histamine test.Gastroenterology 15:110, 1950.

    Google Scholar 

  25. Dragstedt, L. R. A concept of the etiology of gastric and duodenal ulcers.Gastroenterology 30:208, 1956.

    Google Scholar 

  26. Uvnäs, B. The part played by the pyloric region in the caphalic phase of gastric secretion.Acta. physiol. scandiav., 4 Suppl. 13, 1942.

    Google Scholar 

  27. Gergory, R. A. Motor and secretory inhibition of duodenal origin in transplanted gastric pouches.J. Physiol. 132:67, 1956.

    Google Scholar 

  28. Sun, D. C. H. andShay, H. The significance of effect of adrenocortical steroids on the stomach.Physiologist 3:3, Aug. 1960.

    Google Scholar 

  29. Gray, S. J., Ramsey, C., Reifenstein, R. W., andBenson, J. A., Jr. The significance of hormonal factors in the pathogenesis of peptic ulcer.Gastroenterology 25:156, 1953.

    Google Scholar 

  30. Shay, H. Gastric activity and the vagus.M. Clin. North America 1481 (November), 1957.

  31. Edkins, J. S. The chemical mechanism of gastric secretion.Am. J. Physiol. 34:183, 1906.

    Google Scholar 

  32. Edkins, J. S., andTweedy, J. M. The natural channels of absorption evoking the chemical mechanism of gastric secretion.Am. J. Physiol. 38:263, 1908.

    Google Scholar 

  33. Komarov, S. A. Studies on gastrin. II. Physiological properties of the specific gastric secretogogue of the pyloric mucous membrane.Rev. Canad. Biol. 1:377, 1942.

    Google Scholar 

  34. Uvnas, B. Further attempts to isolate a gastric secretory excitant from the pyloric mucosa of pigs.Acta physiol. scandinav. 9:296, 1945.

    Google Scholar 

  35. Dragstedt, L. R. A concept of the etiology of gastric and duodenal ulcer. Caldwell Lecture, 1955.Am. J. Roentgenol. 75:219, 1956.

    Google Scholar 

  36. Dragstedt, L. R. Gastric and duodenal ulcer.Brit. M. J. 1:1234, 1958.

    Google Scholar 

  37. Rowntree, L. G., andSnall, A. Clinical study of Addison's disease. Philadelphia, Saunders, 1931.

    Google Scholar 

  38. Soffer, L. J. Diseases of the Adrenals Philadelphia, Lea, 1948, p. 115.

    Google Scholar 

  39. Sorkin, Z. S. Addison's disease.Medicine 28:371, 1949.

    Google Scholar 

  40. Engel, F. L. Addison's disease and peptic ulcer.J. Clin. Endocrinol. 15:1300, 1955.

    Google Scholar 

  41. Stampien, S. J., andDagradi, A. The histamine response of the gastric mucosa in a patient with adrenal insufficiency: Effect of cortisone administration.Gastroenterology 27:358, 1954.

    Google Scholar 

  42. Kyle, J., Logan, J. S., Neill, D. W., andWelborn, R. B. Influence of the adrenal cortex on gastric secretion in man.Lancet 692:644, 1956.

    Google Scholar 

  43. Tuerkischer, E., andWertheimer, E. Adrenalectomy and gastric secretion.J. Endocrinol. 4:143, 1945.

    Google Scholar 

  44. Madden, R. J., andRamsburg, H. H. Adrenalectomy in Shay rat.Gastroenterology 18:128, 1951.

    Google Scholar 

  45. Welbourn, R. B., andCode, C. F. Effects of cortisone and of adrenalectomy on secretion of gastric acid and on occurrence of gastric ulceration in the pyloric-ligated rats.Gastroenterology 23:356, 1953.

    Google Scholar 

  46. Harvutunian, L. M., andSegal, H. L. The Shay rat as an assay for anti-ulcer factors: IV. The effect of adrenalectomy and nephrectomy.Gastroenterology 21:556, 1952.

    Google Scholar 

  47. Kyle, J., andWelbourn, R. B. The influence of the adenohypophysis and the adrenal cortex on gastric secretion in the rat.Brit. J. Surg. 44:241, 1956.

    Google Scholar 

  48. Baker, B. L., andAbrams, G. D. Effect of hypophysectomy on the cytology of the fundic glands of the stomach and on the secretion of pepsin.Am. J. Physiol. 177:409, 1954.

    Google Scholar 

  49. Baker, B. L., andBridgman, R. M. The history of the gastrointestinal mucosa (rat) after adrenalectomy or administration of adrenocortical hormones.Am. J. Anat. 94:363, 1954.

    Google Scholar 

  50. Gray, S. J., Benson, J. A., Jr., Reifenstein, R. W., andSpiro, H. M. Chronic stress and peptic ulcer. I. Effect of corticotropin (ACTH) and cortisone on gastric secretionJ. A. M. A. 147:1529, 1951.

    Google Scholar 

  51. Kirsner, J. B., andKassriel, R. S. Peptic ulcer: Review of recent literature pertaining to etiology pathogenesis and certain clinical aspects.Advances Int. Med. 8:41, 1956.

    Google Scholar 

  52. Sun, D. C. H., andShay, H. Effect of cortisone, hydrocortisone, and adreno-corticotrophic hormone on gastric secretion in the dog.Fed. Proc. 16:125, 1957.

    Google Scholar 

  53. French, J. D., Porter, R. W., Caranaugh, E. B., andLongmire, R. L. Experimental observations on psychosomatic mechanisms. I. Gastrointestinal disturbances.A.M.A. Arch. Neurol. & Psychiat. 72:267, 1954.

    Google Scholar 

  54. Can Geertruyden, J., Henrotin, E., andColard, M. Action des hormones steroides et de la corticostimuline hypophysaire sur la secretion gastrique et la formation d'ulcères, chez le rat à pylore ligature.Acta gastroenterol, belg. 17:195, 1954.

    Google Scholar 

  55. Zubrian, J., Kark, A. E., andDragstedt, L. R. The effect of ACTH on gastric secretion in experimental animals.Gastroenterology 21:276, 1952.

    Google Scholar 

  56. Dodds, E. C., andNoble, R. L. The action of pituitary extracts on gastric secretion.Proc. Royal Soc., London, O. B. 30:815, 1937.

    Google Scholar 

  57. Villarreai, R., Ganong, W. F., andGray, S. J. Adrenocorticotrophic hormone and gastric secretion of hydrochloric acid, pepsin and electrolytes.Am. J. Physiol. 183:485, 1955.

    Google Scholar 

  58. Zawoiski, E. J., Braunschweig, L. W., andBeyer, K. H. The effect of prednisolone on gastric secretion.J. Pharmacol. & Exper. Therap. 122:512, 1958.

    Google Scholar 

  59. Hirschowitz, B. I., Streeten, D. H. P., Pollard, H. M., andBoldt, H. A. Jr. Role of gastric secretions in activation of peptic ulcers by corticotropin (ACTH)J. A. M. A. 158:27, 1955.

    Google Scholar 

  60. Shay, H., Sun, D. C. H., Dlin, B., andWeiss, E. Gastric secretory response to emotional stress in a case of duodenal ulcer: A consideration of a possible mechanism involved.J. Appl. Physiol. 12:461, 1958.

    Google Scholar 

  61. Sun, D. C. H., Shay, H., Dlin, B., andWeiss, E. Conditioned secretory response of the stomach following repeated emotional stress in a case of duodenal ulcer.Gastroenterology 35:155, 1958.

    Google Scholar 

  62. Turner, F. P. Eosinophil responses to epinephrine and ACTH in peptic ulcer.Gastroenterology 18:419, 1951.

    Google Scholar 

  63. Cummins, A. J., Gompertz, M. L., andJones, M. H. Eosinophil response to adrenocortical stimulation in peptic ulcer disease.New England J. Med. 256:641, 1957.

    Google Scholar 

  64. Sandweiss, D. J., Saltzstein, H. C., Scheinberg, S. R., andParks, A. Hormone studies in peptic ulcer; pituitary, adrenocorticotropic hormone (ACTH) and cortisone.J. A. M. A. 144:1436, 1950.

    Google Scholar 

  65. Cummins, A. J., andGompertz, M. L. Adrenocortical function in peptic ulcer disease.Gastroenterology 33:6, 1957.

    Google Scholar 

  66. Rokitansky, C. A manual of pathological anatomy.Lond. Sydenham Soc. 2:22, 1849.

    Google Scholar 

  67. Schiff, M. M. Leçons sur la physiolgie de digestion. Florence and Turin, Leçon35:416–452, 1867.

    Google Scholar 

  68. Cushing, H. Peptic ulcers and the interbrain.Surg. Gynec. & Obst. 55:1, 1932.

    Google Scholar 

  69. Wath, J. W., andFulton, J. F. The effect of lesions of the hypothalamus upon the gastro-intestinal tract and heart in monkeys.Ann. Surg. 101:363, 1935.

    Google Scholar 

  70. Hoff, E. C., andSheehan, D. Experimental gastric erosions following hypothalamic lesions in monkeys.Am. J. Path. 11:789, 1935.

    Google Scholar 

  71. Keller, A. D. Ulceration in the digestive tract of the dog following intracranial procedures; preliminary study.Arch. Path. 21:127, 1936.

    Google Scholar 

  72. Keller, A. D. Protection by peripheral nerve section of the gastrointestinal tract from ulceration following hypothalamic lesions.Arch. Path. 21:165, 1936.

    Google Scholar 

  73. Porter, R. W., Movius, H. J., andFrench, J. D. Hypothalamic influences on hydrochloric acid secretion of the stomach.Surgery 33:875, 1953.

    Google Scholar 

  74. Gray, S. J., Ramsey, C. G., andThorn, G. W. Adrenal influences on the stomach: Peptic ulcer in Addison's Disease during adrenal steroid therapy.Ann. Int. Med. 45:73, 1956.

    Google Scholar 

  75. Shay, H., andSun, D. C. H. Stress and gastric secretion in man. I. A study of the mechanism involved in insulin hypoglycemia.Am. J. M. Sc. 228:6, 1954.

    Google Scholar 

  76. Vonderahe, A. R. Histopathologic changes in the nervous system in cases of peptic ulcer.Arch. Neurol. & Psychiat. 41:871, 1939.

    Google Scholar 

  77. Wener, J., andHoff, H. E. The neuro-humoral aspects of peptic ulcer formation.Canad. M. A. J. 59:115, 1948.

    Google Scholar 

  78. Curling, P. B. On acute ulceration of the duodenum in cases of burns.Tr. Med. Chir. Soc., London 25:260, 1942.

    Google Scholar 

  79. Derrich, J. R., Wilkinson, A. H., andHoward, J. M. Perforation of stress ulcers of the esophagus following thermal burns.A.M.A. Arch. Surg. 75:17, 1957.

    Google Scholar 

  80. Penner, A., andBernheim, A. Acute postoperative esophageal, gastric and duodenal ulcerations: Further study of pathological changes in shock.Arch. Path. 28:129, 1939.

    Google Scholar 

  81. McDonnell, W. W., andMcGloskey, J. F. Acute peptic ulcers as a complication of surgery.Ann. Surg. 137:67, 1953.

    Google Scholar 

  82. Risholm, L. Acute upper alimentary tract ulcerations and hemorrhage following surgery or traumatic lesions.Acta. chir. scandinav. 110:275, 1956.

    Google Scholar 

  83. Griffiths, H. E. Trauma as a cause of chronic gastric ulcer.Lancet 2:329, 1922.

    Google Scholar 

  84. Malamud, N., Haymaker, W., andCuster, R. P. Heat stroke: a clinicopathologic study of one hundred twenty-five fatal cases.Mil. Surgeon 99:397, 1946.

    Google Scholar 

  85. Wangensteen, O. H., Merendino, K. A., andLitrow, S. S. Hematemesis from erosion or ulcer (gastric and/or duodenal), an occasional complication of fracture.Bull. Am. Coll. Surg. 30:58, 1945.

    Google Scholar 

  86. Selye, H. Thymus and adrenals in the response of the organism to injuries and intoxication.Brit. J. Exper. Path. 17:234, 1936.

    Google Scholar 

  87. Gray, I. Trauma in relation to peptic ulcers.New York State J. Med. 45:887, 1945.

    Google Scholar 

  88. Berkowitz, D., Wagner, B. M., andUrecchio, J. F. Acute peptic ulceration following cardiac surgery.Ann. Int. Med. 46:6, 1957.

    Google Scholar 

  89. Pal, J. Ueber die Wirkung der Hypophysenextrakt auf die Magensaftausscheidung und die Drusensekretion im allgemeinen.Deutsche Med. Wchnschr.42:1030, 1916.

    Google Scholar 

  90. Hess, W. R., andGundlach, R. Der Einfluss von Hypophysenextrake auf die Magensaftsekretion.Arch. f. d. ges. Physiol. 185:137, 1920.

    Google Scholar 

  91. Dodds, E. C., Noble, R. L., andSmith, E. R. A gastric lesion produced by an extract of the pituitary gland.Lancet 2:918, 1934.

    Google Scholar 

  92. Crafts, R. C., andWalker, B. S. The effects of hypophysectomy on gastric acidity of adult female rats.Endocrinology 40:395, 1947.

    Google Scholar 

  93. Borri, A. Ueber Magenschwüre im Klimakterium.Zentralbl. f. inn. Med. 25:689, 1904.

    Google Scholar 

  94. Clark, D. H. Peptic ulcer in women.Brit. M. J. 1:1254, 1953.

    Google Scholar 

  95. Sandweiss, D. J., Slatzstein, H. C., andFarbman, A. A. The relation of sex hormones to peptic ulcer.Am. J. Digest. Dis. 6:6, 1939.

    Google Scholar 

  96. Nasio, J. Influence of some vitamins and hormones in the prevention of experimental cincophen ulcer.Rev. Gastroenterol. 13:195, 1946.

    Google Scholar 

  97. Lerman, J., andMeans, J. H. The gastric secretion in exophthalmic goiter and myxedema.J. Clin. Invest. 11:167, 1932.

    Google Scholar 

  98. Wilkinson, S. A., Jr. Gastric acidity in thyroid dysfunction.J.A.M.A. 101:2097, 1933.

    Google Scholar 

  99. Berryhill, W. R., andWilliams, H. A. A study of the gastric secretion in hyperthyroidism before and after operation.J. Clin. Invest. 11:735, 1932.

    Google Scholar 

  100. Lockwood, B. C. The digestive tract and endocrine function.J.A.M.A. 85:1032, 1925.

    Google Scholar 

  101. Sun, D. C. H., Shay, H., Siplet, H., andGruenstein, M. Effect of experimental athyroidism and hypothyroidism upon gastric secretion in the rat.Gastroenterology 27:189, 1954.

    Google Scholar 

  102. Abrams, G. D., andBaker, B. L. The cytology and secretory action of gastric zymogen cells after ablation of ductless glands.Gastroenterology 27:462, 1954.

    Google Scholar 

  103. Donegan, W. L., andSpiro, H. M. Parathyroids and gastric secretion.Gastroenterology 38:750, 1960.

    Google Scholar 

  104. Rogers, H. M. Parathyroid adenoma and hypertrophy of the parathyroid glands.J.A.M.A. 130:22, 1946.

    Google Scholar 

  105. Rogers, H. M., Keating, R. F., Jr., Morlock, C. G., andBarker, W. W. Primary hypertrophy and hyperplasia of the parathyroid glands associated with duodenal ulcer.Arch. Int. Med. 79:307, 1947.

    Google Scholar 

  106. Howard, J. E., Hopkins, T. R. andConnor, T. B. On certain physiologic responses to intravenous injection of calcium salts into normal, hyperparathyroid and hypoparathyroid persons.J. Clin. Endocrinol. 13:1, 1953.

    Google Scholar 

  107. Hellström, J. Primary hyperparathyroidism. Observations in a series of 50 cases.Acta. endocrinol. 16:30, 1954.

    Google Scholar 

  108. St. Goar, W. T. Was ist die Ursache?J. Clin. Endocrinol. 14:1569, 1954.

    Google Scholar 

  109. Elkeles, A. Parathyroid tumor with hyperparathyroidism and coexistent gastric and duodenal ulceration.Lancet 1:770, 1953.

    Google Scholar 

  110. Poth, E. J., Manhoff, L. J., andDeloach, A. W. The relation of pancreatic secretion to peptic ulcer formation.Surgery 24:62, 1948.

    Google Scholar 

  111. Matthews, W. B., andDragstedt, L. R. The etiology of gastric and duodenal ulcer.Surg., Gynec. & Obst. 55:265, 1952.

    Google Scholar 

  112. Elman, R., andHartman, A. F. Spontaneous peptic ulcers of the duodenum after continued loss of total pancreatic juice.Arch. Surg. 23:1030, 1931.

    Google Scholar 

  113. Poth, E. J., Manhoff, J. L., andDeloach, A. W. The relation of pancreatic secretion to peptic ulcer formation.Gastroenterology 16:490, 1950.

    Google Scholar 

  114. Zollinger, R. M., andEllison, E. H. Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas.Ann. Surg. 142:709, 1955.

    Google Scholar 

  115. Summerskill, W. H. J. Malabsorption and jejunal ulceration due to gastric hypersecretion with pancreatic islet-cell hyperplasia.Lancet 1:120, 1959.

    Google Scholar 

  116. Zollinger, R. M., andElliott, D. W. Pancreatic endocrine function and peptic ulceration.Gastroenterology 37:401, 1959.

    Google Scholar 

  117. Robinson, A. M., Harris, H., Hlad, C. J., andEiseman, B. Effects of glucagon on gastric secretion.Proc. Soc. Exper. Biol. & Med. 96:2, 1957.

    Google Scholar 

  118. Poth, E. J. In discussion of Zollinger, R. M., and Ellison, E. H. Primary peptic ulceration of the jejunum associated with islet cell tumor of the pancreas.Ann. Surg. 142:722, 1955.

    Google Scholar 

  119. Gregory, R. A., Tracy, H., French, J. M., andSircus, W. Extraction of a gastrin-like substance from a pancreatic tumor in a case of Zollinger-Ellison syndrome.Lancet 1:1045, 1960.

    Google Scholar 

  120. Shay, H., Chey, W. Y., andSun, D. C. H. Unpublished data.

  121. Sun, D. C. H., andShay, H. Pancreozymin-secretin test. Combined study of serum enzymes and duodenal contents in diagnosis of pancreatic disease.Gastroenterology 38:570, 1960.

    Google Scholar 

  122. Sun, D. C. H., andShay, H. Optimal effective dose of anticholinergic drug in peptic ulcer.A.M.A. Arch. Int. Med. 97:442, 1956.

    Google Scholar 

  123. Guiss, L. W., andStewart, F. W. Histologic basis for anacidity in gastric disease.Arch. Surg. 57:618, 1948.

    Google Scholar 

  124. Meyers, W. C. A study of gastric mucosa in various diseases affecting the upper part of the gastro-intestinal tract.Gastroenterology 10:923, 1948.

    Google Scholar 

  125. Cox, A. J. Stomach size and its relation to chronic peptic ulcer.Arch. Path. 54:407, 1952.

    Google Scholar 

  126. Card, W. I., andMarks, I. N. The relationship between the acid output of the stomach following “maximal” histamine stimulation and the parietal cell mass.Clin. Sc. 19:147, 1960.

    Google Scholar 

  127. Marks, I. N., andShay, H. Unpublished data.

  128. Kay, A. W. Effect of large doses of histamine on gastric secretion of HCl.Brit. M. J. 2:77, 1953.

    Google Scholar 

  129. Aird, I., Bentall, H. H., andFraser Roberts, J. A. A relationship between cancer of stomach and the ABO blood groups.Brit. M. J. 1:799, 1953.

    Google Scholar 

  130. Aird, I., Bentall, H. H., Mehigan, J. A., andRoberts, J. A. F. The blood groups in relation to peptic ulceration and carcinoma of colon, rectum, breast and bronchus.Brit. M. J. 2:315, 1954.

    Google Scholar 

  131. Clarke, C. A., Cowan, W. K., Edwards, J. W., Howel-Evans, A. W., McConnell, R. B., Woodrow, J. C. andShappard, P. M. The relationship of the ABO blood groups to duodenal and gastric ulceration.Brit. M. J. 2:643, 1955.

    Google Scholar 

  132. Clarke, C. A., Edward, J. W., Haddock, D. R. W., Howel-Evans, A. W., McConnell, R. B., andShappard, P. M. ABO blood groups and secretor character in duodenal ulcer. Population and sibship studies.Brit. M. J. 2:725, 1956.

    Google Scholar 

  133. Clarke, C. A., Price Evans, D. A., McConnell, R. B., andShappard, P. M. Secretion of blood group antigens and peptic ulcer.Brit. M. J. 1:603, 1959.

    Google Scholar 

  134. Koster, K. H., Sindrup, E., andSeele, V. ABO blood-groups and gastric acidity.Lancet 2:52, 1955.

    Google Scholar 

  135. Shay, H. The pathologic physiology of gastric and duodenal ulcer.Bull. New York Acad. Med. 20:264, 1944.

    Google Scholar 

  136. Illingworth, C. F. W. Inborn and extraneous factors in the etiology of peptic ulcer.J. Royal Coll. Surgeons, Edinburgh 2:14, 1956.

    Google Scholar 

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Shay, H. Etiology of peptic ulcer. Digest Dis Sci 6, 29–49 (1961). https://doi.org/10.1007/BF02239245

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