Summary
The HCl response to maximal histamine stimulation was investigated in 428 subjects: 160 DU patients, 113 healthy persons from ulcer families, and 155 controls. The data obtained were correlated with blood group status and secretor status as determined in the saliva. Both DU patients and healthy members of ulcer families showed a highly significant increase of HCl output when compared with the control subjects. Increased gastric acid production in relation to blood Group O and nonsecretion was noted in DU patients and in nonulcerated members of ulcer families. The combined effect of Group O and nonsecretion effaces the difference between duodenal ulcer patients and their relatives in terms of HCl values. The association of blood Group O and nonsecretion genes with an increased capacity for HCl secretion in duodenal ulcer subjects and their healthy relatives might suggest a pleiotropic effect of these genes.
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The authors wish to thank the Institutul de Calcul al Academiei R.S.R. Cluj for statistical and computational services.
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Fodor, O., Vestea, S., Urcan, S. et al. Hydrochloric acid secretion capacity of the stomach as an inherited factor in the pathogenesis of duodenal ulcer. Digest Dis Sci 13, 260–265 (1968). https://doi.org/10.1007/BF02236600
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DOI: https://doi.org/10.1007/BF02236600