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Lymphoepithelioma-like carcinoma of the colon

Report of a case with histologic, immunohistochemical, and molecular studies for epstein-barr virus

  • Case Reports
  • Published:
Diseases of the Colon & Rectum

Abstract

We report a case of lymphoepithelioma-like carcinoma of the colon in a 62-year-old Hispanic male with multiple other tumors, including thyroid, breast, pharyngeal, and prostate carcinomas; a neurofibrosarcoma; and a meningioma. The association with Epstein-Barr virus infection and colonic lymphoepithelioma-like carcinoma was studied using immunohistochemical and polymerase chain reaction techniques.

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References

  1. Schmincke A. Uber lympho-epitheliale Geschwulste. Beitr Pathol Anat Allg Pathol 1921;68:161–70.

    Google Scholar 

  2. Shannmugaratnam K, Sobin LH. Histological typing of upper respiratory tract tumors. International histological classification of tumors, No. 14. Geneva: World Health Organization, 1978.

    Google Scholar 

  3. Weiss L, Gaffey MJ, Shibata D. Lymphoepithelioma-like carcinoma and its relationship to Epstein-Barr virus. Am J Clin Pathol 1991;96:156–8.

    PubMed  Google Scholar 

  4. Sawnson SA, Cooper PH, Mills SE, Wick MR. Lymphoepithelioma-like carcinoma of the skin. Mod Pathol 1988;1:359–65.

    PubMed  Google Scholar 

  5. Butler AE, Colby TV, Weiss LM, Lombard C. Lymphoepithelioma-like carcinoma of the lung. Am J Surg Pathol 1989;13:632–9.

    PubMed  Google Scholar 

  6. Kyung-Whan M, Holmquist S, Peiper SC, O'Leary TJ. Poorly differentiated adenocarcinoma with lymphoid stroma (lymphoepithelioma-like carcinomas) of stomach. Am J Clin Pathol 1991;96:219–27.

    PubMed  Google Scholar 

  7. Watanabe H, Enjoji M, Imai T. Gastric carcinoma with lymphoid stroma. Cancer 1976;38:232–43.

    PubMed  Google Scholar 

  8. Yuen ST, Leung SY, Chan SY.In situ detection of Epstein-Barr virus in gastric and colorectal adenocarcinomas. Am J Surg Pathol 1994;18:1158–63.

    PubMed  Google Scholar 

  9. Oda K, Tamaru J, Takenouchi T,et al. Association of Epstein-Barr virus with gastric carcinoma with lymphoid stroma. Am J Pathol 1993;143:1063–71.

    PubMed  Google Scholar 

  10. Amin MB, Ro JY, Lee KM,et al. Lymphoepithelioma-like carcinoma of the urinary bladder. Am J Surg Pathol 1994;18:466–73.

    PubMed  Google Scholar 

  11. Onijuka M, Mitsui K, Hori M. Undifferentiated carcinoma with prominent lymphocytic infiltration (so-called lymphoepithelioma) in the trachea. Chest 1990;98:236–7.

    PubMed  Google Scholar 

  12. Mills SE, Austin MB, Randall ME. Lymphoepithelioma-like carcinoma of the uterine cervix: a distinctive, un-differentiated carcinoma with inflammatory stroma. Am J Surg Pathol 1985;9:883–9.

    PubMed  Google Scholar 

  13. Dietl J, Horny H-P, Kaiserling E. Lymphoepithelioma-like carcinoma of the vagina: a case report with special reference to the immunophenotype of the tumor cells and tumor-infiltrating lymphoreticular cells. Int J Gynecol Pathol 1994;13:186–9.

    PubMed  Google Scholar 

  14. Saw D, Lau WH, Ho JH, Chan JK, Ng CS. Malignant lympho-epithelial lesion of the salivary gland. Hum Pathol 1986;17:914–23.

    PubMed  Google Scholar 

  15. Weiss LM, Movahed LA, Butler AE,et al. Analysis of lymphoepithelioma and lymphoepithelioma-like carcinomas for Epstein-Barr viral genomes byin situ hybridization. Am J Surg Pathol 1989;13:625–31.

    PubMed  Google Scholar 

  16. Pedneault L, Katz BZ. Comparison of polymerase chain reaction and standard Southern blotting for the detection of Epstein-Barr virus DNA in various biopsy specimens. J Med Virol 1993;39:33–43.

    PubMed  Google Scholar 

  17. Saiki RK, Bugawan TL, Horn GT, Mullis KB, Erlich HA. Analysis of enzymatically amplified-globin and HLA-DQ alpha DNA with allele-specific oligonucleotide probe. Nature 1985;324:164–8.

    Google Scholar 

  18. Lynch H, Smyrle T, Lynch J. Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch Syndrome). Int J Cancer 1996;69:28–43.

    Article  PubMed  Google Scholar 

  19. Jass JR, Smyrk TC, Stewart SM, Lane MR, Lanspa SG, Lynch HT. Pathology of hereditary non-polyposis colorectal cancer. Anticancer Res 1994;14:1631–4.

    PubMed  Google Scholar 

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Samaha, S., Tawfik, O., Horvat, R. et al. Lymphoepithelioma-like carcinoma of the colon. Dis Colon Rectum 41, 925–928 (1998). https://doi.org/10.1007/BF02235379

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