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Salmonella enteritis

I. Role of reduced gastric secretion in pathogenesis

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The American Journal of Digestive Diseases Aims and scope Submit manuscript

Abstract

Marked impairment of gastric acid secretion was associated with cholera-like diarrhea in 3 patients with salmonella enteritis. In contrast, 4 patients with normal or near-normal gastric acid secretion exhibited only mild diarrhea. Patients with reduced gastric acid secretion may not effectively reduce the number of ingested salmonellae; thus, greater numbers of viable organisms may be discharged into the intestine, causing severe enteritis. Patients with impaired gastric acid secretion are not only more susceptible to salmonella infection, but are also subject to more severe enteritis.

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Authors and Affiliations

  1. From the Mallory Gastrointestinal Laboratory; Harvard Medical Unit and the Thorndike Memorial Laboratory, Boston City Hospital, USA

    Ralph A. Giannella MD, Selwyn A. Broitman PhD & Norman Zamcheck MD

  2. the Department of Medicine, Harvard Medical School, USA

    Ralph A. Giannella MD, Selwyn A. Broitman PhD & Norman Zamcheck MD

  3. the Departments of Microbiology and Pathology, Boston University School of Medicine, Boston, Mass.

    Ralph A. Giannella MD, Selwyn A. Broitman PhD & Norman Zamcheck MD

Authors
  1. Ralph A. Giannella MD
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  2. Selwyn A. Broitman PhD
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  3. Norman Zamcheck MD
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Additional information

Supported by Grants CA 04486 and CA 02090 from the National Cancer Institute; TI AM 5320, from the National Institute of Arthritis and Metabolic Diseases; and AI 07913 from the National Institute of Allergy and Infectious Diseases.

The authors wish to thank Dr. Ambrose Keeley for reviewing the histologic material, and Mr. Richard McCabe for technical assistance.

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Giannella, R.A., Broitman, S.A. & Zamcheck, N. Salmonella enteritis. Digest Dis Sci 16, 1000–1006 (1971). https://doi.org/10.1007/BF02235012

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  • DOI: https://doi.org/10.1007/BF02235012

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