Abstract
PURPOSE: The aim of this study was to clarify whether cyclooxygenase-2 and cyclooxygenase-1 is expressed in hyperplastic polyps and serrated adenomas. METHODS: Forty-nine serrated adenomas and 25 hyperplastic polyps were immunostained using anticyclooxygenase-2 and anticyclooxygenase-1 antibodies. Cyclooxygenase-2 and cyclooxygenase-1 expression was investigated in all specimens. RESULTS: Cyclooxygenase-2 was expressed in dysplastic glands in the majority of serrated adenomas. Thirty-five of 49 (71.4 percent) serrated adenomas exhibited moderate to intense cyclooxygenase-2 immunoreactivity, and 8 of 25 hyperplastic polyps (32 percent) showed weak to moderate cyclooxygenase-2 immunoreactivity. Cyclooxygenase-1 immunoreactivity was very weak in all the hyperplastic polyps and serrated adenomas. CONCLUSIONS: These results suggest that cyclooxygenase-2 is overexpressed in serrated adenoma of the colorectum. Cyclooxygenase-2 inhibitors will reduce the incidence of serrated adenomas.
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References
Goldman H, Ming S-C, Hickok DF. Nature and significance of hyperplastic polyps of the human colon. Arch Pathol 1970;89:349–54.
Enterline HT. Pathology of the gastrointestinal tract: polyps and cancer of the large bowel. Curr Top Pathol 1976;63:97–141.
Jackman RJ, Mayo CW. The adenoma-carcinoma sequence in cancer of the colon. Surg Gynecol Obstet 1951;93:327–30.
Vogelstein B, Fearon ER, Hamilton SR,et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525–32.
Longacre TA, Fenoglio-Preiser CM. Mixed hyperplastic adenomatous polyps/serrated adenoma. A distinct form of colorectal neoplasia. Am J Surg Pathol 1990;14:524–37.
Otori K, Oda Y, Sugiyama K,et al. High frequency of K-ras mutations in human colorectal hyperplastic polyps. Gut 1997;40:660–3.
Iino H, Jass JR, Simms LA,et al. DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutated pathway for colorectal cancer? J Clin Pathol 1999;52:5–9.
Kang M, Mitomi H, Sada M,et al. Ki-67, p53, and Bcl-2 expression of serrated adenomas of the colon. Am J Surg Pathol 1997;21:417–23.
Hiyama T, Yokozaki H, Shimamoto F,et al. Frequent p53 gene mutations in serrated adenomas of the colorectum. J Pathol 1998;186:131–9.
Thun MJ, Namboodiri MM, Health CW Jr. Aspirin use and reduced risk of fatal colon cancer. N Engl J Med 1991;325:1593–6.
Giardiello FM, Hamilton SR, Kursh AJ,et al. Treatment of colonic and rectal adenoma with sulindac in familial adenomatous polyposis. N Engl J Med 1993;328:1313–6.
Sandler RS, Galanko JC, Murray SC, Helm JF, Woosley JT. Aspirin and non-steroidal anti-inflammatory agents and risk for colorectal adenomas. Gastroenterology 1998;114:441–7.
Marnett LJ. Aspirin and the potential role of prostaglandins in colon cancer. Cancer Res 1992;52:5575–89.
Rao CV, Rivemson A, Simi B,et al. Chemoprevention of colon carcinogenesis by sulindac, a non-steroidal anti-inflammatory agents. Cancer Res 1995;55:1464–72.
Hla T, Neilson K. Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci U S A 1992;89:7384–8.
Helmer M, Lands WE. Purification of the cyclooxygenase that forms prostaglandins. J Biol Chem 1976;251:5575–9.
Miyamoto T, Ogino N, Yamamoto S, Hayashi O. Purification of prostaglandin endoperoxidase synthase from bovine vesicular gland microsomes. J Biol Chem 1976;251:5575–9.
O'Neil GP, Ford-Hutchinson AW. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett 1993;330:156–60.
Maier JAM, Hla T, Maciag H. Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells. J Biol Chem 1990;265:10805–8.
Lee SH, Soyoola E, Chanmugam P,et al. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem 1992;267:25934–8.
Sano H, Kawahito Y, Wielder RL,et al. Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res 1995;55:3785–9.
Maekawa M, Sugano K, Sano H,et al. Increased expression of cyclooxygenase-2 to -1 in human colorectal cancers and adenomas, but not in hyperplastic polyps. Jpn J Clin Oncol 1998;28:421–6.
Croizet O, Moreau J, Arany Y, Delvaux M, Rumeau JL, Escourrou J. Follow-up patients with hyperplastic polyps of the large bowel. Gastrointest Endosc 1997;46:119–23.
Uchida H, Ando H, Maruyama K,et al. Genetic alterations of mixed hyperplastic adenomatous polyps in the colon and rectum. Jpn J Cancer Res 1998;89:299–306.
Hao X, Bishop AE, Wallace M,et al. Early expression of cyclo-oxygenase-2 during sporadic colorectal carcinogenesis. J Pathol 1999;187:295–301.
Franzin G, Novelli P. Adenocarcinoma occurring in a hyperplastic (metaplastic) polyp of the colon. Endoscopy 1982;14:28–30.
Dimberg J, Samuelsson A, Hugander A, Soderkvist P. Differential expression of cyclooxygenase 2 in human colorectal cancer. Gut 1999;45:730–2.
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Arao, J., Sano, Y., Fujii, T. et al. Cyclooxygenase-2 is overexpressed in serrated adenoma of the colorectum. Dis Colon Rectum 44, 1319–1323 (2001). https://doi.org/10.1007/BF02234791
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DOI: https://doi.org/10.1007/BF02234791