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Efficacy of calcium dobesilate in treating acute attacks of hemorrhoidal disease

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Diseases of the Colon & Rectum

Abstract

PURPOSE: A randomized, double-blind, controlled study was conducted to investigate the efficacy of oral calcium dobesilate therapy in treating acute attacks of internal hemorrhoids. METHODS: Twenty-nine well-documented adult patients with first- or second-degree internal hemorrhoids were treated with calcium dobesilate for two weeks, while 16 patients received only a high-fiber diet to serve as control. Both symptoms and anoscopic inflammation were scored on a scale from 0 to 2 before (T0) and two weeks after treatment (T2). RESULTS: A success rate of 86.21 percent with cessation of bleeding plus lack of severe anitis anoscopically at two weeks were achieved with calcium dobesilate. The pretreatment symptom score of 2 fell significantly to 0.45±0.13, and the pretreatment anitis score of 1.69±0.09 fell to 0.55±0.12 at T2 (P=0.0001 for both comparisons). The symptom and anoscopic inflammation scores obtained with calcium dobesilate treatment were also significantly better than those with diet only (P=0.0017 andP=0.0013, respectively). CONCLUSION: Together with recommendations about diet and bowel discipline, oral calcium dobesilate treatment provides an efficient, fast, and safe symptomatic relief from acute symptoms of hemorrhoidal disease. This symptomatic healing is associated with a significant improvement in the anoscopically observed inflammation.

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Authors and Affiliations

  1. From the Department of Surgery, Gazi University Medical School, Ankara, Turkey

    B. Bülent Menteş M.D. & Ertan Tatlicioğlu M.D.

  2. From the Department Gastroenterology, Gazi University Medical School, Ankara, Turkey

    Ahmet Görgül M.D.

  3. From the Department Public Health, Gazi University Medical School, Ankara, Turkey

    Ferruh Ayoğlu M.D. & Selahattin Ünal M.D.

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  1. B. Bülent Menteş M.D.
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  2. Ahmet Görgül M.D.
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Bülent Menteş, B., Görgül, A., Tatlicioğlu, E. et al. Efficacy of calcium dobesilate in treating acute attacks of hemorrhoidal disease. Dis Colon Rectum 44, 1489–1495 (2001). https://doi.org/10.1007/BF02234604

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