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Use of carbonic anhydrase inhibitor in the treatment of pancreatitis

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Summary

Carbonic anhydrase inhibitors have been shown to effectively reduce the volume of pancreatic secretion. Pancreatic duct hypertension, resulting from the combination of ductal obstruction and exocrine hypersecretion, appears to play an important role in the pathogenesis of pancreatitis. With ductal hypertension, enzymes enter the interstitial tissues of the pancreas and initiate an acute inflammatory response which may vary from simple edema to necrosis.

Clinical experience with the use of acetazolamide in 26 patients with various types of acute pancreatitis suggests that this agent is a valuable adjunct in the therapy of pancreatitis. The management of acute pancreatitis, including the use of acetazolamide, is discussed.

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Authors and Affiliations

  1. From the Department of Surgery, Northwestern University Medical School, Chicago, Ill.

    Marion C. Anderson M.D. (Research Fellow) & Michael K. Copass B.A.

  2. Kemper Foundation, American College of Surgeons, USA

    Marion C. Anderson M.D. (Research Fellow)

Authors
  1. Marion C. Anderson M.D.
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  2. Michael K. Copass B.A.
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Anderson, M.C., Copass, M.K. Use of carbonic anhydrase inhibitor in the treatment of pancreatitis. Digest Dis Sci 11, 367–376 (1966). https://doi.org/10.1007/BF02233631

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  • DOI: https://doi.org/10.1007/BF02233631

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