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Gastric secretion and ulcer formation after hypophysectomy and administration of somatotrophic hormone

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Summary

Transauricular hypophysectomy in rats was found to reduce gastric secretion to very low levels (volume, acid, pepsin, mucus, expressed in terms of hexosamine). Treatment for 5 days with bovine STH (somatotrophic or growth hormone) restored nearly completely the acid, partially the volume and mucus, but not the pepsin. In another series of rats, it was found that hypophysectomy reduced by half the sensitivity to prednisolone-induced ulcers. This protection by hypophysectomy is not explained. It is not due to the lack of STH because treatment with this hormone reduced further the occurrence of ulcerations to almost complete inhibition. The antiulcer property of STH, manifested in spite of an increase in acid secretion, may be mediated through its increasing effects on mucus secretion; it may also be due to a stimulation of gastric connective tissue.

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Authors and Affiliations

  1. From the Metabolic Diseases Research, The Upjohn Company, Kalamazoo, Mich.

    André Robert M.D., Ph.D., J. Paul Phillips B.Sc. & James E. Nezamis B.Sc.

Authors
  1. André Robert M.D., Ph.D.
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  2. J. Paul Phillips B.Sc.
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  3. James E. Nezamis B.Sc.
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Robert, A., Phillips, J.P. & Nezamis, J.E. Gastric secretion and ulcer formation after hypophysectomy and administration of somatotrophic hormone. Digest Dis Sci 11, 546–552 (1966). https://doi.org/10.1007/BF02233566

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  • DOI: https://doi.org/10.1007/BF02233566

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