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Inhibition of gastric mucous secretion by ACTH an experimental study

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Summary

The rate of secretion and the biochemical composition of mucus secreted by the gastric antrum of dogs were studied before and during administration of ACTH. ACTH caused a decrease in the rate of secretion of the mucus and an alteration in its biochemical composition, characterized by a decrease in the carbohydrate:protein ratio. The data suggest that ulceration during ACTH administration and during stress may be due to impaired mucosal defense mechanisms.

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Authors and Affiliations

  1. From the Department of Surgery, University of Chicago School of Medicine, Chicago, Ill.

    Laurent Desbaillets M.D. & René Mencuy M.D., Ph.D.

Authors
  1. Laurent Desbaillets M.D.
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  2. René Mencuy M.D., Ph.D.
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Additional information

Supported in part by Grant AM 10423-01 from the National Institutes of Health, U. S. Public Health Service, and Grant P-329G from the American Cancer Society.

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Desbaillets, L., Mencuy, R. Inhibition of gastric mucous secretion by ACTH an experimental study. Digest Dis Sci 12, 582–588 (1967). https://doi.org/10.1007/BF02233495

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  • DOI: https://doi.org/10.1007/BF02233495

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