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Diet, cholesterol gallstones, and composition of the bile

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Conclusions

Studies on bile composition with respect to diet, quantity, and composition have been carried out. The composition of Ttube bile has been studied in a group of patients having cholecystectomy for cholelithiasis, and a group of patients having cholecystectomy for other reasons. Our studies suggest that the formation of cholesterol gallstones is related to two factors: (1) An increase in biliary cholesterol concentration when caloric and daily protein intake increases and (2) an increased intake of calories irrespective of diet composition.

The in-vitro conditions for precipitation and solubilization of biliary cholesterol are now rather well established. In addition, the changes in biliary cholesterol, bile salts, and phospholipid concentration may be studied under defined experimental conditions. Our studies suggest that the bile of patients with cholelithiasis has a composition from time to time which is favorable for the formation of gallstones. The variations in bile composition appear to be dependent upon the diet: the greater the caloric intake, the more frequently will bile have a composition which favors cholesterol precipitation.

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Authors and Affiliations

  1. From the Unité de Recherches de Pathologie Digestive, Marseille, France

    Henri Sarles MD, Docteur ès Sci, Jacques Hauton MD, Docteur ès Sci, N. Elizabeth Planche, Huguette Lafont & André Gerolami MD

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  1. Henri Sarles MD
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  2. Docteur ès Sci
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  3. Jacques Hauton MD
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  6. Huguette Lafont
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  7. André Gerolami MD
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Sarles, H., Sci, D.è., Hauton, J. et al. Diet, cholesterol gallstones, and composition of the bile. Digest Dis Sci 15, 251–260 (1970). https://doi.org/10.1007/BF02233456

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