Skip to main content
Log in

Lactosuria in the African with lactase deficiency

  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

Summary

African subjects in Uganda with isolated lactase deficiency have a significant lactosuria after an oral lactose load. This can be detected by the Clinitest method, and probably has a value in screening African populations for lactase deficiency.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Darling, S., Mortensen, O., andSøndergaard, G. Lactosuria and amino-aciduria in infancy.Acta Paediat (Uppsala) 49:281, 1960.

    Google Scholar 

  2. Holzel, A., Mereu, T., andThomson, M. L. Severe lactose intolerance in infancy.Lancet 2:1346, 1962.

    Article  PubMed  Google Scholar 

  3. Durand, P. Disorders due to intestinal defective carbohydrate digestion and absorption. II pensiero scientifico, Rome 1964, p. 115.

    Google Scholar 

  4. Arthur, A. B., Clayton, B. E., Cottom, D. G., Seakins, J. W. T., andPlatt, J. W. Importance of disaccharide intolerance in the treatment of coeliac disease.Lancet 1:172, 1966.

    Article  PubMed  Google Scholar 

  5. Weser, E., andSleisenger, M. H. Lactosuria and lactase deficiency in adult celiac disease.Gastroenterology 48:571, 1965.

    PubMed  Google Scholar 

  6. Sheehy, T. W., Anderson, P. R., andBaggs, B. E. Carbohydrate studies in tropical sprue.J Indian Med Profess 12:5432, 1965.

    Google Scholar 

  7. Auricchio, S., Rubino, A., Landolt, M., Semenza, G., andPrader, A. Isolated intestinal lactase deficiency in the adult.Lancet 2:324, 1963.

    Article  Google Scholar 

  8. Kern, F., Struthers, J. E., andAttwood, W. L. Lactose intolerance as a cause of steatorrhoea in an adult.Gastroenterology 45:477, 1963.

    PubMed  Google Scholar 

  9. Dahlqvist, A., Hammond, J. B., Crane, R. K., Dunphy, J. V., andLittman, A. Intestinal lactase deficiency and lactose intolerance in adults.Gastroenterology 45:488, 1963.

    PubMed  Google Scholar 

  10. Welsh, J. D., Rohrer, V., Knudsen, K. B., andPaustian, F. F. Isolated lactase deficiency. Correlation of laboratory studies and clinical data.Arch Intern Med (Chicago) 120:261, 1967.

    Google Scholar 

  11. Gryboski, J. D., Thayer, W. R., Gabrielson, I. W., andSpiro, H. M. Disacchariduria in Gastrointestinal disease.Gastroenterology 45:633, 1963.

    PubMed  Google Scholar 

  12. Cook, G. C., andKajubi, S. K. Tribal incidence of lactase deficiency in Uganda.Lancet 1:725, 1966.

    Article  PubMed  Google Scholar 

  13. Cook, G. C. Lactase activity in newborn and infant Baganda.Brit Med J 1:527, 1967.

    PubMed  Google Scholar 

  14. Cuatrecasas, P., Lockwood, D. H., andCaldwell, J. R. Lactase deficiency in the adult.Lancet 1:14, 1965.

    Article  Google Scholar 

  15. Bayless, T. M., andRosensweig, N. S. A racial difference in incidence of lactase deficiency.JAMA 197:968, 1966.

    Article  PubMed  Google Scholar 

  16. McMichael, H. B., Webb, J., andDawson, A. M. Jejunal disaccharidases and some observations on the cause of lactase deficiency.Brit Med J 2:1037, 1966.

    PubMed  Google Scholar 

  17. Cook, G. C., andLee, F. D. The jejunum after kwashiorkor.Lancet 2:1263, 1966.

    Article  PubMed  Google Scholar 

  18. Woolf, L. I. Use of ion-exchange resins in paper chromatography of sugars.Nature (London) 171:841, 1953.

    Google Scholar 

  19. Smith, I. Chromatographic and electrophoretic techniques (Vol. 1). Heinemann, London, 1960, p. 246.

    Google Scholar 

  20. Carleton, F. J., Misler, S., andRoberts, H. R. Comparison of the metabolism of C14 labeled lactose, glucose, and galactose in rats.J Biol Chem 214:427, 1955.

    PubMed  Google Scholar 

  21. Weser, E., andSleisenger, M. H. Metabolism of circulating disaccharides in man and the rat.J Clin Invest 46:499, 1967.

    PubMed  Google Scholar 

  22. Banwell, J. G., Hutt, M. S. R., andTunnicliffe, R. Observations on jejunal biopsy in Ugandan Africans.E Afr Med J 41:46, 1964.

    Google Scholar 

  23. Cook, G. C., Kajubi, S. K., andLee, F. D. Jejunal morphology of the African in Uganda. Submitted for publication.

Download references

Author information

Authors and Affiliations

Authors

Additional information

We are grateful to Prof. R. A. McCance, F.R.S., for his help with this investigation.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cook, G.C., Howells, G.R. Lactosuria in the African with lactase deficiency. Digest Dis Sci 13, 634–637 (1968). https://doi.org/10.1007/BF02232970

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02232970

Keywords

Navigation