Summary
A patient with cirrhosis and ascites is reported whose edema and ascites were cured by diuresis with intensive therapy. However she developed progressive uremia, hyponatremia, and coma. This ominous complication was reversed by infusions of blood, albumin, and molar sodium and restriction of water intake.
Similar content being viewed by others
References
Hecker, R., andSherlock, S. Electrolyte and circulatory changes in terminal liver failure.Lancet 2: 1121, 1956.
Martini, G. A., andRausch-Strooman, J. G. Hyponatriamiesyndrom nach kochsalzfreier Kost, erzwunger Diurese und/oder Ascitespunktion bei chronischer Leberin-suffizienz; Hyponatriamie, Hypochloramie, Hyperkaliami, Azotamie.Klin. Wchnsch. 37:385, 1959.
Summerskill, W. H. J., Clowdow, B. F., andCasey, A. H. Clinical and metabolic changes during the development of azotemia in hepatic failure with ascites.Proc. Staff Meet. Mayo Clin. 35:783, 1960.
Asada, M., andGalambos, J. T. Sorbitol dehydrogenase activity in serum and tissue —an index of hepatocellular injury. To be published.
Papper, S., Belsky, J. L., andBleifer, K. H. Renal failure in Laennec's cirrhosis of the liver. I. Description of clinical and laboratory features.Ann. Int. Med. 51:759, 1959.
Nelson, W. P., III, Rosenbaum, J. D., andStrauss, M. B. Hyponatremia in hepatic cirrhosis following paracentesis.J. Clin. Invest. 30:738, 1951.
Schroeder, H. A. Renal failure associated with a low extracellular sodium chloride: The low salt syndrome.J.A.M.A., 141:117. 1949.
Author information
Authors and Affiliations
Additional information
This study was supported in part by USPHS Grant H-4714.
Rights and permissions
About this article
Cite this article
Galambos, J.T., Wilkinson, H.A. Reversible hyponatremia and azotemia in a patient with cirrhosis and ascites. Digest Dis Sci 7, 642–647 (1962). https://doi.org/10.1007/BF02232779
Issue Date:
DOI: https://doi.org/10.1007/BF02232779