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The contribution of Sir James Paget (1814–1894) to the study of rheumatic disease

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References

  1. Paget, S. Memoirs and Letters of Sir James Paget. 3rd ed. Longmans, Green and Co., 1903.

  2. Roberts, S.Sir James Paget, The Rise of Clinical Surgery. Eponymists in Medicine Series. Editor-in Chief Hugh L'Etang. Royal Society of Medicine Services Ltd., 1989.

  3. Paget, J. Account of the trichina spiralis. Transactions of the Abernethian Society, 1835. Note in St. Bartholomews Hospital Report. 1868,4, 276–277.

    Google Scholar 

  4. Paget, J. Letter on the discovery of trichina spiralis. Lancet. 1866,1, 269.

    Google Scholar 

  5. Owen, R. Sir. Description of a microscopic entozoon (trichina spiralis) infesting the muscles of the human body. London Medical Gazette. 1834–35,16, 125–127.

    Google Scholar 

  6. Gould, S.E. Trichinosis. Springfield, Illinois, Charles C. Thomas, 1945.

    Google Scholar 

  7. Royal College of Surgeons of England,Descriptive Catalogue of the Pathological Specimens. London, W. Clowes, Taylor and Francis, 1846–1864.

    Google Scholar 

  8. Paget, J. and Paget, J.C.Sketch of the Natural History of Yarmouth and its Neighbourhood, Containing Catalogues of the Species of Animals, Birds, Reptiles, Fish, Insects and Plants at Present Known. Yarmouth, Skill, 1834.

    Google Scholar 

  9. Paget, J. On a form of chronic inflammation of the bones-osteitis deformans. Transactions of Medical Chir. Society. 1877,60, 37–64.

    Google Scholar 

  10. Paget, J. Additional cases of osteitis deformans, notes on seven cases. Transactions of Medical Chir. Society. 1882,65, 225–236.

    Google Scholar 

  11. Paget, J. Remarks on osteitis deformans. Illustrated Medical News, 1889,2, 181–182.

    Google Scholar 

  12. Power, Sir D'A. Eponyms: Sir James Paget. British Journal of Surgeons, 1922,10, 161–164.

    Google Scholar 

  13. Barry, H.C.Paget's Disease of Bone. Edinburgh, E. and S. Livingstone, 1965, p.3.

    Google Scholar 

  14. Collins, D.H.Pathology of Bone. London, England, Butterworth. 1966 pp. 228–248.

    Google Scholar 

  15. Gigliotti, S., Giuzio, E. and DeDurante, C. Fractures in Paget's disease. Chir Organi Mov. 1990,75, 331–336.

    PubMed  Google Scholar 

  16. Singer, F.R. and Krane, S.M. Paget's disease of bone. Chapter 15. In:Metabolic Bone Disease and Clinically Related Disorders. 2nd ed., Eds.: L.V. Avioli, and S.M. Krane. Philadelphia, W.B. Saunders Company. 1990, pp.546–615.

    Google Scholar 

  17. Kanis, J.Pathophysiology and Treatment of Paget's Disease of Bone. Durham, North Carolina, USA. Carolina Academic Press. 1991.

    Google Scholar 

  18. Altman, R.D. Paget's disease of bone. Chapter 43. In:Disorders of Bone and Mineral Metabolism. Eds. F.L. Coe, M.J. Favus. New York, New York, USA. Raven Press. 1992, pp. 1027–1064.

    Google Scholar 

  19. Bradley, C.M. and Nade, S. Outcome after fractures of the femur in Paget's disease. Aust. N.Z. J. Surg. 1992,62, 39–44.

    PubMed  Google Scholar 

  20. Röntgen, W.C. Ueber eine neue Art von Strahlen. S.B. physmed. Ges. Würzburg 1895, 132–141. (English translation) In: Nature. 1896,53, 274 and 377.

    Google Scholar 

  21. Hamdy, R.C.Paget's Disease of Bone Assessment and Management. New York, New York, USA. Praeger Publishers, 1981.

    Google Scholar 

  22. Wick, M.R., Siegal, G.P. and Unni, K.K. et al. Sarcomas of bone complicating osteitis deformans (Paget's disease). Am. J. Surg. Pathol. 1981,5, 47-.

    PubMed  Google Scholar 

  23. Monson, D.K., Finn, H.A., Dawson, P.J. and Simon, M.A. Pseudosarcoma in Paget's disease of bone. J. Bone Jt. Surg. 1989,71A, 453–455.

    Google Scholar 

  24. Dromer, C., Caulier, M., Le Guennec, P., et al. Tumor-like bone dystrophy and peripheral joint fusion in a patient with Paget's disease of bone. Rev. Rhum. Engl. Ed. 1995,62, 142–146.

    PubMed  Google Scholar 

  25. Jaffe, H.L. Paget's disease of bone. Arch. Pathol. 1933,15, 83.

    Google Scholar 

  26. Robbie, M.J., Pratsis, K.K. and Lockie, D.J. Intraosseous lipomata in Paget's disease: an unusual CT appearance. Australas. Radiol. 1991,35, 268–270.

    PubMed  Google Scholar 

  27. Carrillo, R., Morales, A., Rodriguez-Peralto, J.L., Lizama, J. and Eslava, J.M. Benign fibro-osseous lesions in Paget's disease of the jaws. Oral Surg. Oral. Med. Oral. Pathol. 1991,71, 588–592.

    PubMed  Google Scholar 

  28. Upchurch, K.S., Simon, L.S. and Schiller, A.L. et al. Giant cell reparative granuloma of Paget's disease of bone: a unique clinical entity. Ann. Intern. Med. 1983,98, 35–40.

    PubMed  Google Scholar 

  29. Jaffe, H.L.Metabolic, Degenerative and Inflammatory Diseases of Bones and Joints. Philadelphia, Pennsylvania, USA. Sea and Febiger, 1972.

    Google Scholar 

  30. Mirra, J.M. and Gold, R.H. Case report 186: giant tumour containing virus-like intra nuclea inclusions in association with Paget's disease. Skeletal Radiol. 1982,8, 67–70.

    PubMed  Google Scholar 

  31. Jacobsen, H.G. and Siegleman, S.S. Some miscellaneous solitary bone lesions. Semin. Roentgenal 1966,1, 314–335.

    Google Scholar 

  32. Igou, D., Sundaram, M., McDonald, D.J., Janney, C. and Chalk, D.E. Appendicular metastatic prostrate cancer simulating osteosarcoma, Paget's disease, and Paget's sarcoma. Skeletal. Radiol. 1995,24, 447–449.

    PubMed  Google Scholar 

  33. Milgram, J.W. Osteitis deformans (Paget disease) Chapter 45 In:Radiology and Histologic Pathology of Nontumorous Diseases of Bones and Joints Vol.2. Northbrook, Illinois, USA. Northbrook Publishing Co. Inc. 1990, pp. 869–932.

    Google Scholar 

  34. Moore, T.E., King, A.R., Kathol, M.H., et al. Sarcoma in Paget disease of bone: clinical, radiologic, and pathologic features in 22 cases. AJR. Am. J. Roentgenol. 1991,156, 1199–1203.

    PubMed  Google Scholar 

  35. Wick, M.R., Siegel, G.P. and Unni, G.P., et al. Sarcomas of bone complicating osteitis deformans (Paget's disease): fifty years' experience. American Journal of Surgical Pathology. 1981,5, 47–59.

    PubMed  Google Scholar 

  36. Huvos, A.G. Osteogenic sarcoma of bones and soft tissues in older persons. A clinicopathologic analysis of 117 patients older than 60 years. Cancer. 1986,57, 1442–1449.

    PubMed  Google Scholar 

  37. Miller, M.D. Orthopaedic pathology Chapter 7 In:Review of Orthopaedics. Philadelphia, Pennsylvania, USA. W.B. Saunders Company. 1992, pp. 167–211.

    Google Scholar 

  38. Bhambhani, M., Lamberty, B.G., Clements, M.R., Skingle, S.J. and Crisp, A.J. Giant cell tumours in mandible and spine: a rare complication of Paget's disease of bone. Ann. Rheum. Dis. 1992,51, 1335–1337.

    PubMed  Google Scholar 

  39. Singer, F.R., and Mills, B.G. Giant cell tumor arising in Paget's disease of bone. Recurrences after 36 years. Clin. Orthop. 1993, 293–301.

  40. Jacobs, T.P., Michelsen, J. and Polay, J.S. et al. Giant cell tumour in Paget's disease of bone. Familial and geographic clustering. Cancer. 1979,44, 742–747.

    PubMed  Google Scholar 

  41. Wu, R.K., Trumble, T.E. and Ruwe, P.A. Familial incidence of Paget's disease and secondary osteogenic sarcoma. A report of three cases from a single family. Clin. Orthop. 1991, 306–309.

  42. Hoyland, J. and Sharpe, P.T. Upregulation of c-fos protooncogene expression in pagetic osteoclasts. J. Bone Miner. Res. 1994,9, 1191–1194.

    PubMed  Google Scholar 

  43. Altman, R.D. Articular complications of Paget's disease of bone. Semin. Arthritis Rheum. 1994,23, 248–249.

    PubMed  Google Scholar 

  44. Radi, I., Epiney, J., and Reiner, M. Chondrocalcinose et maladie osseuse de Paget. Rev. Rheum. Mal. Osteoartic. 1970,37, 385–388.

    Google Scholar 

  45. Franck, W.A., Bress, N.M., Singer, F.R. and Krane, S.M. Rheumatic manifestations of Paget's disease of bone. American Journal of Medicine, 1974,56, 592–603.

    PubMed  Google Scholar 

  46. Fennelly, J.J. and Hogan, A. Pseudouridine excretion — a reflection of high RNA turnover in Paget's disease. Journal of Medical Science. 1972,141, 103–107.

    Google Scholar 

  47. Kuo, J.S., Fallon, M.D., Gannon, F.H., et al. The articular manifestations of Paget's disease of bone. A case report. Clin. Orthop. 1992, 250–254.

  48. Arnalich, F., Plaza, I., Sobrino, J.A. et al. Cardiac size and function in Paget's disease of bone. International Journal of Cardiology. 1984,5, 491–505.

    PubMed  Google Scholar 

  49. Rongstad, K.M., Wheeler, D.L. and Enneking, W.F. A comparison of the amount of vascularity in Pagetic and normal human bone. Clin. Orthop. 1994, 247–249.

  50. Khetarpal, U. and Schuknecht, H.F. In search of pathologic correlates for hearing loss and vertigo in Paget's disease. A clinical and histopathologic study of 26 temporal bones. Ann Rhinol.Laryngol.Suppl. 1990,145, 1–16.

    Google Scholar 

  51. Ginsberg, L.E., Elster, A.D. and Moody, D.M. MRI of Paget disease with temporal bone involvement presenting with sensorineural hearing loss. J. Comput. Assist. Tomogr. 1992,16, 314–316.

    PubMed  Google Scholar 

  52. Monsell, E.M., Cody, D.D., Bone, H.G., et al. Hearing loss in Paget's disease of bone: the relationship between pure-tone thresholds and mineral density of the cochlear capsule. Hear Res. 1995,83, 114–120.

    PubMed  Google Scholar 

  53. Wheeler, T.T., Alberts, M.A., Dolan, T.A., and McGorray, S.P. Dental, visual, auditory and olfactory complications in Paget's disease of bone. J. Am. Geriatr. Soc. 1995,43, 1384–1391.

    PubMed  Google Scholar 

  54. Sellars, S.L. Beethoven's deafness. S. A. Med. J. 1974,48, 1585–1588.

    Google Scholar 

  55. Ober, W.B. Beethoven: a medical view. Practioner,205, 1970, 819–824.

    Google Scholar 

  56. Dawes, P.J. Beethoven's deafness: a new theory. Medical Journal of Australia, 1988,149, 644–649.

    PubMed  Google Scholar 

  57. Paton, D.The Relation of Angioid Streaks to Systemic Disease. Springfield, Illinois, USA., Charles C. Thomas, 1972.

    Google Scholar 

  58. Clarkson, J.G. and Altman, R.D. Angioid streaks. Surv. Opthalmology. 1982,25, 235–246.

    Google Scholar 

  59. Dabbs T.R. and Skjodt, K. Prevalence of angioid streaks and other ocular complications of Paget's disease of bone. Br. J. Ophthalmol. 1990,74, 579–582.

    PubMed  Google Scholar 

  60. Smith, R. Paget's disease and angioid streaks: one complication less? (Editorial) Br. J. Ophthalmol. 1990,74, 577–578.

    PubMed  Google Scholar 

  61. Dohrmann, P.J., Elrick, W.L. Dementia and hydrocephalus in Paget's disease. A case report. Journal of Neurol. Neurosurg. Psychiatry. 1982,45, 835–837.

    Google Scholar 

  62. Aguiar, P.H., Andrioli, M.S., Cabrera, H.N., Cabral, N.D., and Scaff, M. Management of hydrocephalus in Paget's disease. A case report. Zentralbl. Neurochir. 1994,55, 60–62.

    PubMed  Google Scholar 

  63. Czerny, V. Eine Lakale Maladie des Unterschenkels. Wiener Med. Wochenschrift. 1873,23, 895–925.

    Google Scholar 

  64. Looser, E. Deforming osteitis and diseases seemingly akin to it. Schweiz Med Wchschr. 1926,56, 598–603.

    Google Scholar 

  65. Erdheim, J. Über senile Hyperoste des Schädeldaches. Beitr. Anat. Path. 1935,95, 631–646.

    Google Scholar 

  66. Piga, A.M., Lopez-Abente, G. and Ibanez, A.E. et al. Risk factors for Paget's disease: a new hypothesis. Int. J. Epidemiol. 1988,17, 198–201.

    PubMed  Google Scholar 

  67. Barker, D.J.P., Chamberlain, A.T. and Guyer, P.B. et al. Paget's disease of bone: the Lancashire focus. British Medical Journal. 1980,280, 1105–1107.

    PubMed  Google Scholar 

  68. Barker, D.J.P. The epidemiology of Paget's disease. Metab. Bone Dis. Rel. Res. 1981,4, 231–234.

    Google Scholar 

  69. Detheridge, F.M., Guyer, P.B. and Barker, D.J.P. European distribution of Paget's disease of bone. British Medical Journal. 1982,285, 1005–1008.

    PubMed  Google Scholar 

  70. Barker, D.J. The epidemiology of Paget's disease of bone. British Medical Bulletin. 1984,40, 396–400.

    PubMed  Google Scholar 

  71. Morales-Piga, A., Lopez-Abente, G., Garcia-Vadillo, A. and Ibanez, A.E. Characteristics de la enfermdad de Paget del hueso en un nuevo foco de elevada prevalencia. Med. Clin. (Barc) 1990,95, 169–174.

    Google Scholar 

  72. Mautalen, C., Pumarino, H. and Blanco, M.C. et al. Paget's disease: the South American experience. Sem. Arthritis Rheum. 1994,23, 226–227.

    Google Scholar 

  73. Franck, W.A., Bress, N.M., Singer, F.R. and Krane, S.M. Rheumatic manifestations of Paget's disease of bone. American Journal of Medicine. 1974,56, 592–603.

    PubMed  Google Scholar 

  74. Sofaer, J.A., Holloway, S.M. and Emery, A.E.H. A family study of Paget's disease of bone. J. Epidemiol Community Health. 1983,37, 226–231.

    PubMed  Google Scholar 

  75. Siris, E.S., Ottman, R., Flaster, E. and Kelsey, J.L. Familial aggregation of Paget's disease of bone. J. Bone Miner Res 1991,6, 495–500.

    PubMed  Google Scholar 

  76. Gallacher, S.J. Paget's disease of bone. Curr. Opin. Rheumatol. 1993,5, 351–356.

    PubMed  Google Scholar 

  77. Siris, E. Epidemiological aspects of Paget's disease: family history and relationship to other medical conditions. Sem. Arthritis Rheum. 1994,23, 222–225.

    Google Scholar 

  78. Morales-Piga, A.A., Rey-Rey, J.S., Corres-Gonzalez, J., Garcia-Sagredo, J.M. and Lopez-Abente, G. Frequency and characteristics of familial aggregation of Paget's disease of bone. J. Bone Miner. Res. 1995,10, 663–670.

    PubMed  Google Scholar 

  79. Melick, R.A. and Martin, T.J. Paget's disease in identical twins. Aust. N.Z. J. Med. 1975,5, 564–565.

    PubMed  Google Scholar 

  80. Singer, F.R., Mills, B.G. and Park, M.S. et al. Increased HLA-DQWI antigen pattern in Paget's disease of bone. Clin. Res. 1985,33, 574A.

  81. Foldes, J., Shamir, S., Brauther, C., Schermann. L. and Menczel, J. HLA-D antigens and Paget's disease of bone. Clin. Orthop. 1991, 301–303.

  82. Gordon, M.T., Cartwright, E.J., Mercer, S., Anderson, D.C. and Sharpe, P.T. HLA polymorphisms in Paget's disease of bone. Semin. Arthritis Rheum. 1994,23, 229.

    PubMed  Google Scholar 

  83. Harvey, I. Viral aetiology of Paget's disease of bone: a review. J. Roy. Soc. Med. 1984,77, 943–948.

    Google Scholar 

  84. Mills, B.G. and Singer, F.R. Critical evaluation of viral antigen data in Paget's disease of bone. Clin. Orthop. 1987,217, 16–25.

    PubMed  Google Scholar 

  85. Kahn, A.J. The viral etiology of Paget's disease of bone: a new perspective. Calcified Tissue International. 1990,47, 127–129.

    PubMed  Google Scholar 

  86. Gordon, M.T., Mee, A.P. and Sharpe, P.T. Paramyxoviruses and Paget's disease. Sem. Arthritis Rheum. 1994,23, 232–234.

    Google Scholar 

  87. Gordon, M.T., Anderson, D.C. and Sharpe, P.T. Canine distemper virus localised in bone cells of patients with Paget's disease. Bone. 1991,12, 195–201.

    PubMed  Google Scholar 

  88. Gordon, M.T., Mee, A.P. and Anderson, D.C. et al. Canine distemper virus transcripts sequenced from Pagetic bone. Bone. Miner. 1992,19, 159–174.

    PubMed  Google Scholar 

  89. Cartwright, E.J., Gordon, M.T., Freemont, A.J., Anderson, D.C. and Sharpe, P.T. Paramyxoviruses and Paget's disease. J. Med. Virol. 1993,40, 133–141.

    PubMed  Google Scholar 

  90. Gordon, M.T., Bell, S.C., Mee, A.P., et al. Prevalence of canine distemper antibodies in the Pagetic population. J. Med. Virol. 1993,40, 313–317.

    PubMed  Google Scholar 

  91. Mee, A.P., Gordon, M.T. and May, C. et al. Canine distemper virus transcripts detected in the bone cells of dogs with metaphysical osteopathy. Bone. 1993,14, 59–67.

    PubMed  Google Scholar 

  92. O'Driscoll, J.B., Anderson, D.C. Past pets and Paget's disease. Lancet. 1985,2, 919–921.

    PubMed  Google Scholar 

  93. O'Driscoll, J.B., Buckler, H.M. and Jeacock, J. et al. Dogs, distemper and osteitis deformans: a further epidemiological study. Bone Miner. 1990,11, 209–216.

    PubMed  Google Scholar 

  94. Holdaway, I.M., Ibbertson, H.K. and Wattie, D. et al. Previous dog ownership in Paget's disease. Bone Miner. 1990,8, 53–58.

    PubMed  Google Scholar 

  95. Mills, B.G., Frausto, A., Singer, F.R., et al. Multinucleated cells formed in vitro from Paget's bone marrow express viral antigens. Bone. 1994,15, 443–448.

    PubMed  Google Scholar 

  96. Mii, Y., Miyauchi, Y., Honoki, K., et al. Electron microscopic evidence of a viral nature for osteoclast inclusions in Paget's disease of bone. Virchows Arch. 1994,424, 99–104.

    PubMed  Google Scholar 

  97. Reddy, S.V., Singer, F.R., and Roodman, G.D. Bone marrow mononuclear cells from patients with Paget's disease contain measles virus nucleocapsid messenger ribonucleic acid that has mutations in a specific region of the sequence. J. Clin. Endocrinol. Metab. 1995,80, 2108–2111.

    PubMed  Google Scholar 

  98. Ralston, S.H., Digiovine, F.S., Gallacher, S.J., Boyle, I.T. and Duff, G.W. Failure to detect paramyxovirus sequences in Paget's disease of bone using the polymerase chain reaction. J. Bone Miner. Res. 1991,6, 1243–1248.

    PubMed  Google Scholar 

  99. Nuovo, M.A., Nuovo, G.J., MacConnell, P., et al. In situ analysis of Paget's disease of bone for measles-specific PCR-amplified cDNA. Diagn. Mol. Pathol., 1992,1, 256–265.

    PubMed  Google Scholar 

  100. Birch, M.A., Taylor, W., Fraser, W.D., et al. Absence of paramyxovirus RNA in cultures of Pagetic bone cells and in Pagetic bone. J. Bone Miner. Res. 1994,9, 11–16.

    PubMed  Google Scholar 

  101. Mills, B.G., Yabe, H. and Singer, F.R. Osteoclasts in human osteopetrosis contain viral-nucleocapsid-like nuclear inclusions. J. Bone Mineral Res. 1988,3, 101–106.

    Google Scholar 

  102. Bianco, P., Silvestrini, G., Ballanti, P. and Bonucci, E. Paramyxovirus-like nuclear inclusions identical to those of Paget's disease of bone detected in giant cells of primary oxalosis. Virchows Arch. A. Pathol. Anat. Histopathol. 1992,421, 427–433.

    PubMed  Google Scholar 

  103. Roodman, G.D., Kurihara, N., Ohsaki, Y., et al. Interleukin 6. A potential autocrine/paracrine factor in Paget's disease of bone. J. Clin. Invest. 1992,89, 46–52.

    PubMed  Google Scholar 

  104. Hoyland, J.A., Freemont, A.J. and Sharpe, P.T. Interleukin-6, IL-6 receptor, and IL-6 nuclear factor gene expression in Paget's disease. J. Bone Miner. Res. 1994,9, 75–80.

    PubMed  Google Scholar 

  105. DeMulder, A., Takahashi, S., Singer, F.R. et al. Abnormalities in osteoclast precursors and marrow accessory cells in Paget's disease. Endocrinology. 1993,133, 1978–1982.

    PubMed  Google Scholar 

  106. Ralston, S.H., Hoey, S.A., Gallacher, S.J., Adamson, B.B. and Boyle, I.T. Cytokine and growth factor expression in Paget's disease: analysis by reverse-transcription/polymerase chain reaction. British Journal of Rheumatology. 1994,33, 620–625.

    PubMed  Google Scholar 

  107. Rapado, A., Yague, M. and Diaz Curiel, M. et al. Cellular immunodeficiency in Paget's disease of bone: changes induced by treatment with elcatonin. Calcif. Tissue Int. 1991,49, 436–437.

    PubMed  Google Scholar 

  108. Alvarez, I., Guanabens, N., Peris, P., et al. Discriminative value of biochemical markers of bone turnover in assessing the activity of Paget's disease. J. Bone Miner Res. 1995,10, 458–465.

    PubMed  Google Scholar 

  109. Rubini, G., Lauriero, F., Rubini, D. and D'Addabbo, A. 99Tcm-MDP global skeletal uptake and markers of bone metabolism in patients with bone diseases. Nucl. Med. Commun. 1993,14, 567–572.

    PubMed  Google Scholar 

  110. Kaufman, G.A., Sundaram, M. and McDonald, D.J. Magnetic resonance imaging in symptomatic Paget's disease. Skeletal Radiology. 1991,20, 413–418.

    PubMed  Google Scholar 

  111. Potter, H.G., Schneider, R., Ghelman, B., Healey, J.H. and Lane, J.M. Multiple giant cell tumours and Paget disease of bone: radiographic and clinical correlations. Radiology. 1991,180, 261–264.

    PubMed  Google Scholar 

  112. Smith, R., Russell, R.G.G. and Bishop, M. Diphosphonates and Paget's disease of bone. Lancet. 1971,1, 945–957.

    Google Scholar 

  113. Nagrani de Deuxchaines, C. and Krane, S.M. Paget's disease of bone. Clinical and metabolic observations. Medicine (Baltimore) 1964,43, 233–266.

    Google Scholar 

  114. Altman, R.D., Johnston, C.C. and Khairi, M.R.A. et al. Influence of disodium etidronate on clinical and laboratory manifestations of Paget's disease of bone (osteitis deformans). New England Journal of Medicine. 1973,289, 1379–1384.

    PubMed  Google Scholar 

  115. Finerman, G.A.M., Gonick, H.C. and Smith, R.K. et al. Diphosphonate treatment of Paget's disease. Clin. Orthop. 1976,120, 115–124.

    PubMed  Google Scholar 

  116. Vellenga, C.J.L.R., Pauwels, E.K.J., Buvoet, O.L.M. and Hoskings, D.J. Evaluations of scintigraphic and roentgenologic studies in Paget's disease under treatment. Radiol. Clin. 1976,45, 292–301.

    Google Scholar 

  117. Canfield, R., Rosners, W, and Skinner, J. et al. Diphosphonate therapy of Paget's disease of bone. J. Clin. Endocrinol. Metab. 1977,44, 96–106.

    PubMed  Google Scholar 

  118. Patel, S., Lyons, A.R. and Hosking, D.J. Drugs used in the treatment of metabolic bone disease. Clinical pharmacology and therapeutic use. Drugs, 1993,46, 594–617.

    PubMed  Google Scholar 

  119. Ryan, W.G., Schwartz, T.B. and Perlia, C.P. Effects of mithramycin on Paget's disease of bone. Ann. Intern. Med. 1969,70, 549–557.

    PubMed  Google Scholar 

  120. Elias, E.G. and Evans, J.T. Mithramycin in the treatment of Paget's disease of bone. J. Bone Joint Surg. 1972,54A, 1730–1735.

    Google Scholar 

  121. Ryan, W.G. and Schwartz, T.B. Mithramycin treatment of Paget's disease of bone. Arthritis Rheum. 1980,23, 1155–1161.

    PubMed  Google Scholar 

  122. Ryan, W.G. and Fordham, E.W. Mithramycin and Paget's disease revisited. Letter Ann. Intern. Med. 1984,100, 771-.

    Google Scholar 

  123. Bijvoet, O.L.M., and Jansen, A.P. Thyrocalcitonin in Paget's disease. Lancet. 1967,2, 471–472.

    Google Scholar 

  124. Canniggia, A. and Gennari, C. Azione della tirocalcitona nell'uomo. Minerva Med. 1968,59, 279–295.

    PubMed  Google Scholar 

  125. Woodhouse, N.J.Y., Bordier, Ph. and Fisher, M. et al. Human calcitonin in the treatment of Paget's bone disease. Lancet. 1972,2, 992–994.

    PubMed  Google Scholar 

  126. Avramides, A. Paget's disease of bone: treating Paget's disease with calcitonin. Curr. Concepts Bone Dis. 1976,1, 2–5.

    Google Scholar 

  127. Fornasier, V.L., Stapleton, K. and Williams, C.C. Histologic changes in Paget's disease treated with calcitonin. Hum Pathol 1978,9, 455–461.

    PubMed  Google Scholar 

  128. Muff, R., Dambacher, M.A. and Perrenoud, A. et al. Efficacy of intranasal human calcitonin in patients with Paget's disease refractory to salmon calcitonin. American Journal of Medicine. 1990,89, 181–184.

    PubMed  Google Scholar 

  129. Reginster, J.Y., Gennari, C. and Mautalen, C. et al. Influence of specific anti-salmon calcitonin antibodies on biological effectiveness of nasal salmon calcitonin in Paget's disease of bone. Scand J Rheum 1990,19, 83–86.

    PubMed  Google Scholar 

  130. Walker, G.S., Evanson, J.M., Canty, D.P. and Gill, N.W. Effect of calcitonin on deafness due to Paget's disease of skull. Br Med J 1979,2, 364–365.

    PubMed  Google Scholar 

  131. El Sammaa, M., Linthicum, F.Jr., House, H.P. and House, J.W. Calcitonin as treatment for hearing loss in Paget's disease. Am J Otol 1986,1, 241–243.

    Google Scholar 

  132. Melick, R.A., Eberling, P. and Hjhorth, R.J. Improvement in paraplegia in vertebral Paget's disease treated with calcitonin. Br Med J 1976,1, 627–628.

    Google Scholar 

  133. Crosbie, W.A., Mohamedally, S.M. and Woodhouse, N.J.Y. Effect of salmon calcitonin on cardiac output, oxygen transport and bone turnover in patients with Paget's disease. Clin. Sci. Mol. Med. 1975,48, 537–540.

    Google Scholar 

  134. Ibbertson, H.K. The cardiovascular system in Paget's disease of bone and response to therapy with calcitonin and diphosphonate. Aust N Z J Med 1979,9, 390–397.

    PubMed  Google Scholar 

  135. Avioli, L.V. and Berman, M.I. Role of magnesium metabolism and the effects of fluoride therapy in Paget's disease of bone. J Clin Endocrinol 1968,28, 700–710.

    Google Scholar 

  136. Condon, J.R. Glucagon in the treatment of Paget's disease of bone. Br Med J 1971,4, 719–721.

    PubMed  Google Scholar 

  137. Nagant de Deuxchaisnes and Krane, S.M. Paget's disease of bone: clinical and metabolic observations. Medicine (Baltimore). 1964,43, 233–266.

    Google Scholar 

  138. Kaplan, F.S. Paget's disease of bone: orthopedic complications. Sem Arthritis Rheum 1994,23, 250–252.

    Google Scholar 

  139. McDonald, D.J. and Sim, F.H. Total hip arthroplasty in Paget's disease. J Bone Jt Surg 1987,69A, 766–772.

    Google Scholar 

  140. Ludkowski, P. and Wilson-MacDonald, J. Total arthroplasty in Paget's disease of the hip. A clinical review and review of the literature. Clin Orthop 1990, 160–167.

  141. Meyers, M.H., Singer, D. and Singer, F.R. Osteotomy for tibia vara in Paget's disease under cover of calcitonin. J Bone Jt Surg 1978,60A, 810–814.

    Google Scholar 

  142. Frankle, M., Tiegs, R.D. and Sim, F.H. A review of corrective osteotomies for deformity in Paget's disease. Sem Arthritis Rheum 1994,23, 253.

    Google Scholar 

  143. Gabel, G.T., Rand, J.A., and Sim F.H. Total knee arthroplasty for osteoarthrosis in patients who have Paget's disease of bone at the knee. J Bone Joint Surg 1991,73, 739–744.

    PubMed  Google Scholar 

  144. Barlow, I.W., and Thomas, N.P. Reconstruction nailing for subtrochanteric fractures in the Pagetic femur. Injury 1994,25, 426–428.

    PubMed  Google Scholar 

  145. O'Driscoll, S.W. and Hastings, D.E. Extension of monostatic Paget disease from the femur to the tibia after arthrodesis of the knee. J Bone Jt Surg 1989,71A, 129–132.

    Google Scholar 

  146. Rullier, P.R. Sur un accroissement extraordinaire de os plats. Bull Fac Med Paris 1812,2, 94. Cited by Paget (9).

    Google Scholar 

  147. Wrany. Spongiose Hyperostose des Schadels, des Beckins und des linken. Oberschenkels Vierteijahresschr Prakt Heilkd. 1867,93, 79–95.

    Google Scholar 

  148. Wilks, S. Case of osteoporosis, or spongy hypertrophy of the bones (calvaria, clavicle, or femoris and rib, exhibited at the Society). Trans Pathol Soc London 1869,20, 273–277.

    Google Scholar 

  149. Denninger, H.S. Paleopathological evidence of Paget's disease. Ann Med Hist 1933,5, 73–81.

    Google Scholar 

  150. Fisher, A.K. Additional paleopathological evidence of Paget's disease. Ann Med Hist 1935,7, 197–8.

    Google Scholar 

  151. Wells, C. and Woodhouse, N. Paget's disease in an Anglo-Saxon. Med. Hist. 1975,19, 396–400.

    PubMed  Google Scholar 

  152. Hooper, B. The Saxon burials. In:Excavation at Porchester Castle, Hants II (Saxon). Ed.: B. Cuncliffe, London, England. Society of Antiquities 1976, pp. 235–261.

    Google Scholar 

  153. Stirland, A. Paget's disease (osteitis deformans): A classic case? Int J Osteoarchaeol 1991,1, 173–7.

    Google Scholar 

  154. Byock, J.L. Egil's bones. Scientific American 1995,272, 82–87.

    Google Scholar 

  155. Aaron, J.E., Rogers, J. and Kanis, J.A. Palaeohistology of Paget's disease in two medieval skeletons. Am J Phys Anthropol 1992,89, 325–31.

    PubMed  Google Scholar 

  156. Price, J.L. The radiology of excavated Saxon and medieval human remains from Winchester. Clin Radiol 1975,26, 363–370.

    PubMed  Google Scholar 

  157. McKay, C.V. Some pathological changes in Australian aboriginal bones. Medical Journal of Australia. 1938,ii, 537–555.

    Google Scholar 

  158. Wells, C. Pseudopathology Chapter I. In:Diseases in Antiquity. Eds.: D. Brothwell, A.T. Sandison, Springfield, Illinois, USA Charles C. Thomas, 1967, pp. 5–19.

    Google Scholar 

  159. White, E.P.C. Osteitis deformans in monkeys. Arch Int Med 1922,30, 790–796.

    Google Scholar 

  160. Orr, J.W. Osteoporosis in a rabbit with osseous changes resembling Paget's disease. J Path Bact 1937,45, 29-.

    Google Scholar 

  161. Dequeker, J. Paget's disease in a painting by Quinten Metsys (Massys). Br Med J 1989,299, 1579–81.

    Google Scholar 

  162. Sharma, P. Paget's disease in a painting by Quinten Metsys (Massys) Letter. British Medical Journal,300.

  163. Backwin, H. and Eiger, M.S. Fragile bones and macrocranium. J Pediatrics. 1956,49, 558–564.

    Google Scholar 

  164. Caffey, J. Familial hyperphosphatasia with ateliosis and hypermelabolism of growing membranous bone: a review of the clinical, radiographic and chemical features. Prog. Pediatr. Radiol 1973,4, 438–468.

    Google Scholar 

  165. Silve, C. Hereditary hypophosphatasia and hyperphosphatasia. Curr Opin Rheumatol 1994,6, 336–339.

    PubMed  Google Scholar 

  166. Paget, J. On the production of some of the loose bodies in joints. St. Bartholomew's Hospital Report. 1870,6, 1–4.

    Google Scholar 

  167. König, F.Lehrbuch der Allgemeinen Chirurgie für Aerzte und Studierende, Berlin, 1889, p. 751.

  168. Paget, J. A case of necrosis of the femur, without external inflammation. Transactions of Clinical Society. London, 1870, 3, 183–186.

    Google Scholar 

  169. Milgram, J.W. Nonunion and pseudoarthrosis of fracture healing. In:Radiologic and Histologic Pathology of Nontumorous Diseases of Bones and Joints. Vol. I. Northbrook, Illinois, USA., Northbrook Publishing Company Inc. 1990, Chapter 20, 385–424.

    Google Scholar 

  170. Osgood, R.B. Lesions of the tibial tubercle occurring during adolescence. Boston Medical Surgical Journal. 1903,148, 114–117.

    Google Scholar 

  171. Schlatter, C. Verletzungen des schnabelförmigen Fortsatzes der oberen Tibia-epiphyse. Beitr Klin Chir 1903,38, 874–887.

    Google Scholar 

  172. Resnick, D. and Niwayama, G.Diagnosis of Bone and Joint Disorders 2nd ed. Philadelphia, Pennsylvania, USA., W.B. Saunders Company. 1988, pp. 3313–3316.

    Google Scholar 

  173. Rang, M.Anthology of Orthopaedics. Edinburgh, Churchill Livingstone, 1966.

    Google Scholar 

  174. Paget, J. Periostosis following strains In:Studies of Old Casebooks: Seventeen Essays on Subjects in Surgical Pathology and Practice. London, England, Longman, 1891.

    Google Scholar 

  175. Marie, P. and Foix, C. Atrophie isolée de L'éminence thénar d'origine névritque, röle du legament anulaire antérior du carpe dans la pathogénie de la lésion. Rev Neur Paris26, 1913, pp. 647–649.

    Google Scholar 

  176. Omerod, J.A. St. Bartholomew's Hospital Reports. 1883,19, 17–26. cited by Rang (173).

    Google Scholar 

  177. Woltman, H.W. Neuritis associated with acromegaly. Arch Neurol Psychiat 1941,45, 680–682.

    Google Scholar 

  178. Paget, Sir J.Lectures on Surgical Pathology. Vol. I. London, England, Longmans 1853, P. 43.

    Google Scholar 

  179. Paget, J. On gouty and some other forms of phlebitis. St. Bartholomew's Hospital Report 1866,2, pp. 82–92.

    Google Scholar 

  180. Kelley, W.N., Fox, I.H., and Palella, T.D. Gout and related disorders of purine metabolism. In:Textbook of Rheumatology. 3rd ed. Eds.: W.N. Kelley, E.D. Harris, S. Ruddy, and C.B. Sledge Philadelphia, Pennsylvania, USA., W.B. Saunders Company. Section XV Crystal-Associated Synovitis. Chapter 78. 1989, 1395–1448.

    Google Scholar 

  181. Paget, J. The Bradshawe Lecture on some rare and new diseases. British Medical Journal. 1882,2, 1189–1193.

    Google Scholar 

  182. Anonymous. The Bradshawe Lecture at the Royal College of Surgeons. British Medical Journal. 1882,2, 1221.

  183. Anonymous. New and rare diseases and Sir James Paget on the evolution of diseases. Br Med J 1882,2, 1217–1218.

  184. Charcot, J.M. Sur quelques arthropathies qui paraissent dépendre d'une lésion du cerveau ou de la moelle épinière. Arch. Physial. Norm. Pathol. 1868,1, 161–178 and 379–400.

    Google Scholar 

  185. Charcot, J.M. Ataxie locomotrice progressive: arthropathie de l'épaule gauche Resultats necropsiques. Arch Physiol Norm Pathol 1869,2, 121.

    Google Scholar 

  186. Charcot, J.M. Remarks on a case of locomotor ataxy with hydrarthrosis. St. George's Hospital Report. 1869,4, 259–260.

    Google Scholar 

  187. Charcot, J.M.Lectures on the Diseases of the Nervous System. Vol. 2. Edited and translated by S. Sigerson. London, England. The New Sydenham Society 1881, pp. 49–61.

    Google Scholar 

  188. Marshall, A.J. and Burton, J.A.G.Catalogue of the Pathological Preparations of William Hunter, Sir William Macewen, Professor John H. Teacher and Professor J.A.G. Burton in the Museum of the Pathology Department, Glasgow Royal Infirmmary.Glasgow, Scotland. Glasgow, Scotland, University of Glasgow, 1962.

    Google Scholar 

  189. Buchanan, W.W. and Laurent, R.M. Rheumatoid arthritis: An example of ecological succession? Can Bull Med History 1990,7, 77–91.

    Google Scholar 

  190. Paget, J. Remarks in discussion on joint disease in connection of locomotor ataxy. Transactions Clinical Society. London, 1885,18, 66–70.

    Google Scholar 

  191. Paget, J.Catalogue of the Pathological Specimens in the Museum of St. Bartholomew's. St. Bartholomews Hospital, London, England. 1846.

    Google Scholar 

  192. Waugh, D. The decline and fall of our medical museums. Canadian Medical Association Journal. 1990,142, 236.

    PubMed  Google Scholar 

  193. Paget, J. Clinical lecture cases that bone-setters cure. British Medical Journal. 1867,1, 1–4.

    Google Scholar 

  194. Hilton, J.Rest and Pain. Ed.: W.H.A. Jacobsen, London, England. G. Bell and Sons Limited. 1920.

    Google Scholar 

  195. Shorter, E.From Paralysis to Fatigue A History of Psychosomatic Illness in the Modern Era. New York, New York, USA. The Free Press (a division of Macmillan, Inc.). 1992.

    Google Scholar 

  196. Osler, W.Aequanimitas. With Other Addresses to Medical Students, Nurses and Practitioners of Medicine. Philadelphia, Pennsylvania, USA. the Blakiston Company. 1932, pp. 258–259.

    Google Scholar 

  197. Paget, J. On diseases of the mammary areola preceding cancer of the mammary gland. St. Bartholomews Hospital Report. 1874,10, 87–89.

    Google Scholar 

  198. Kuehn, P.G., Tennant, R. and Brenneman, A.R. Familial occurrence of extramammary Paget's disease. Cancer. 1973,31, 145–148.

    PubMed  Google Scholar 

  199. Paget, J.Clinical Lectures and Essays. London, England. Langman Green. 1875, p. 292.

    Google Scholar 

  200. Paget, J. Recurring fibroid and fibro-nucleated tumors In:Lectures on Surgical Pathology. Vol. 2. London, England. Longman. 1853, p. 155.

    Google Scholar 

  201. Paget, J. On residual abscesses. St. Bartholomew's Hospital Report 1869,5, 73–79.

    Google Scholar 

  202. Paget, J. Clinical lectures on diseased ankle talipes, diseased metatarso-phalangeal joints etc. Lancet 1869,1, 151–152.

    Google Scholar 

  203. Osler, W. The VII International Medical Congress, London August 10, 1881. Canadian Medical Surgical Journal. Montreal. 1881–1882,10, 121–125.

    Google Scholar 

  204. Paget, J. On the treatment of fractures of the leg. Lancet 1869,1, 317–319.

    Google Scholar 

  205. Lister, J. Remarks on a case of compound dislocation of the ankle with other injuries, illustrating the antiseptic treatment. Lancet 1869,1, 360–368.

    Google Scholar 

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Buchanan, W. The contribution of Sir James Paget (1814–1894) to the study of rheumatic disease. Clin Rheumatol 15, 461–472 (1996). https://doi.org/10.1007/BF02229643

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