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Biochemical markers of myocardial necrosis in acute myocardial infarction and thrombolysis

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Abstract

This paper summarizes the most important biochemical properties of several biochemical markers of myocardial injury and discusses the practical applications of these markers for the diagnosis of acute myocardial infarction, for the noninvasive detection of coronary artery recanalization after treatment with thrombolytic agents, and for the early identification of cardiovascular events in unstable angina.

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References

  1. Abendschein D, Ellis A, Eisenberg P, Klocke F, Sobel B, Jaffe A (1991) Prompt detection of coronary recanalization by analysis of rates of change of concentrations of macromolecular markers in plasma. Coronary Artery Dis 2:201–212

    Google Scholar 

  2. Adams J III, Adendschein D, Jaffe A (1993) Biochemical markers of myocardial injury. Is MB creatine kinase the choice of the 1990s? Circulation 88:750–763

    PubMed  Google Scholar 

  3. Almog C, Isakov A, Ayalon D, Burke M, Shapira I (1987) Serum myoglobin in detection of myocardial necrosis in patients with coronary insufficiency. Clin Cardiol 10:347–349

    PubMed  Google Scholar 

  4. Bodor G, Porter S, Landt Y, Ladenson J (1992) The development of monoclonal antibodies and an assay for cardiac troponin-I with preliminary results in suspected myocardial infarction. Clin Chem 11:2203–2214

    Google Scholar 

  5. Burlina A, Zaninotto M, Secchiero S, Rubin D, Accorsi F (1994) Troponin T as a marker of ischemic myocardial infarction. Clin Biochem 27:113–121

    PubMed  Google Scholar 

  6. Cummins B, Auckland M, Cummins P (1987) Cardiac-specific troponin-I radioimmunoassay in the diagnosis of acute myocardial infarction. Am Heart J 113:1333–1344

    PubMed  Google Scholar 

  7. Drexel H, Dworzak E, Kirchmair W, Milz M, Puschendorf B, Diemstel F (1983) Myoglobinemia in the early phase of acute myocardial infarction. Am Heart J 105:642–650

    PubMed  Google Scholar 

  8. Garabedian H, Gold H, Yasuda T, Johns J, Finkelstein D, Gaivin R (1988) Detection of coronary artery reperfusion with creatine kinase-MB determination during thrombolytic therapy: correlation with acute therapy. J Am Coll Cardiol 11:729–734

    PubMed  Google Scholar 

  9. Gasser R, Hauptlorenz S, Dworzak E, Moll W, Puschendorf D, Dienstl F (1987) The typical staccato phenomenon of myoglobin in acute myocardial infarction disappears under thrombolytic treatment. Fibrinolysis 1:177–182

    Google Scholar 

  10. Gerhardt W, Katus H, Ravkilde J, Hamm C, Jørgensen P, Peheim E, Ljungdahl L, Löfdahl P (1991) S-Troponin T in suspected ischemic myocardial injury compared with mass and catalytic concentrations of screatine kinase isoenzyme MB. Clin Chem 97:1405–1411

    Google Scholar 

  11. Glatz J, Kliene A, van Nieuwenhoven FA, Hermens WT, van Dieijen-Visser M, van der Vusse G (1994) Fatty-acid-binding protein as a plasma marker for the estimation of myocardial infarct size in humans. Br Heart J 71:135–140

    PubMed  Google Scholar 

  12. Gore J, Roberts R, Ball S, Montera A, Goldberg R, Dalen J (1987) Peak creatine kinase as a measure of effectiveness of thrombolytic therapy in acute myocardial infarction. Am J Cardiol 59:1234–1238

    PubMed  Google Scholar 

  13. Grande P, Granborg J, Clemmensen P, Sevilla D, Wagner N, Wagner G (1991) Indices of reperfusion in patients with acute myocardial infarction using characteristics of the CK-MB time activity curve. Am Heart J 122:400–408

    PubMed  Google Scholar 

  14. Hamm C, Ravkilde J, Gerhardt W, Jörgensen P, Peheim E, Ljungdahl L, Goldmann B, Katus HA (1992) The prognostic value of serum troponin T in unstable angina. N Engl J Med 327:146–150

    PubMed  Google Scholar 

  15. Hoberg E, Katus H, Diederich K, Kübler W (1987) Myoglobin, creatine kinase-B isoenzyme, and myosin light chain release in patients with unstable angina pectoris. Eur Heart J 8:989–994

    PubMed  Google Scholar 

  16. Irvin R, Cobb F, Roe C (1980) Acute myocardial infarction and MB creatine phosphokinase: relationship between onset of symptoms of infarction and appearence and disappearence of enzyme. Arch Intern Med 140:329–334

    PubMed  Google Scholar 

  17. Isobe M, Nagai R, Yamoki K, Nakaoka H, Takaku F, Yazaki Y (1989) Quantification of infarct size after coronary reperfusion by serum cardiac myosin light chain II in conscious dogs. Circ Res 65:684–694

    PubMed  Google Scholar 

  18. Jablonsky G, Leung K, Henderson A (1985) Changes in LD1/ LD2 ratio during the first day after myocardial infarction. Clin Chem 31:1621–1624

    PubMed  Google Scholar 

  19. Kagen L, Scheidt S, Butt A (1977) Serum myoglobin in myocardial infarction: the “staccato phenomenon”. Am J Med 62:86–92

    PubMed  Google Scholar 

  20. Katus H, Diederich K, Hoberg E, Kübler W (1988) Circulating cardiac myosin light chains in patients with angina at rest: identification of a high risk subset. J Am Coll Cardiol 11:487–493

    PubMed  Google Scholar 

  21. Katus H, Dietrich K, Schwartz F, Vellner M, Kübler WT (1987) Influence of reperfusion on serum concentration of cytosolic creatine kinase and structural myosin light chains in acute myocardial infarction. Am J Cardiol 60:440–445

    PubMed  Google Scholar 

  22. Katus H, Remmpis A, Scheffold T, Dietrich K, Kübler W (1991) Intracellular compartmentation of cardiac troponin T and its release kinetics in patients with reperfused and nonreperfused myocardial infarction. Am J Cardiol 67:1360–1367

    PubMed  Google Scholar 

  23. Katus H, Remppis A, Looser S, Hallermeier K, Scheffold T, Kübler W (1989) Enzyme-linked immunoassay of cardiac troponin T for the detection of acute myocardial infarction in patients. J Mol Cell Cardiol 21:1349–1353

    PubMed  Google Scholar 

  24. Katus H, Yasuda T, Gold H, Lienbach R, Strauss H, Waksmonski C, Haber E, Khaw B (1984) Diagnosis of acute myocardial infarction by detection of circulating cardiac myosin light chains. Am J Cardiol 54:964–970

    PubMed  Google Scholar 

  25. Klocke F, Copley D, Krawszy J, Reichlin M (1982) Rapid renal clearence of immunoreactive canine plasma myoglobin. Circulation 65:1522–1528

    PubMed  Google Scholar 

  26. Larue C, Calzolari C, Bertinchant J-P, Leclercq F, Grolleau R, Pau B (1993) Cardiac-specific immunoenzymometric assay of troponin I in the early phase of acute myocardial infarction. Clin Chem 39:972–979

    PubMed  Google Scholar 

  27. Lee T, Goldman L (1986) Serum enzyme assays in the diagnosis of acute myocardial infarction. Ann Intern Med 105:221–233

    PubMed  Google Scholar 

  28. Léger J, Lague C, Ming T, Calzolari C, Gaultier P, Mouton C, Grolleau R, Louisot P, Puech P, Peperstraete B, Staroukine M, Telerman M, Pau B, Leger J (1990) Assay of serum cardiac myosin heavy chain fragments in patients with acute myocardial infarction: determination of infarct size and long-term follow-up. Am Heart J 120:781–790

    PubMed  Google Scholar 

  29. Marshall T, Williams J, Williams K (1991) Electrophoresis of serum enzymes and proteins following acute myocardial in-farction. J Chromatogr 569:323–345

    PubMed  Google Scholar 

  30. Michael L, Hunt J, Weilbaecher D et al. (1985) Creatine kinase and phosphorylase in cardiac lymph: coronary occlusion and reperfusion. Am J Physiol 248:350–359

    Google Scholar 

  31. Miyata M, Abe S, Arima S, Nomoto K, Kawataki M, Ueno M, Yamashita T, Hamasaki S, Toda H, Tahara M, Atsuchi Y, Nakao S, Tanaka H (1994) Rapid diagnosis of coronary reperfusion by measurement of myoglobin level every 15 min in acute myocardial infarction. J Am Coll Cardiol 23:1009–1015

    PubMed  Google Scholar 

  32. Nomura M, Kato K, Nagasaka A, Shiga Y, Miyaga Y, Fukui R, Watanabe Y, Mizuno Y (1987) Serum β-enolase in acute myocardial infarction. Br Heart J 58:29–33

    PubMed  Google Scholar 

  33. Rabitzsch G, Mair J, Lechleitner P, Noll F, Hofmann U, Krause E, Dienstl F, Puschendorf B (1993) Isoenzyme BB of glycogen phosphorylase b and myocardial infarction. Lancet 341:1032–1033

    Google Scholar 

  34. Rabitzsch G, Schulz H, Onnen K, Kössler A, Krause E (1987) Immunoinhibition assay of serum activity of human glycogen isophosphorylase BB in the diagnosis of acute myocardial ischemia. Biomed Biochim Acta 46:584–588

    Google Scholar 

  35. Remppis A, Scheffold T, Karrer O, Zehelein J, Hamm C, Grünig E, Bode C, Kübler W, Katus HA (1994) Assessment of reperfusion of the infarct zone after acute myocardial infarction by serial cardiac troponin T measurements in serum. Br Heart J 71:242–248

    PubMed  Google Scholar 

  36. Roberts R (1977) Myoglobinemia as an index to myocardial infarction. Ann Intern Med 87:788–789

    PubMed  Google Scholar 

  37. Seguin J, Saussine M, Ferrierre M, Leger J, Leger J, Lame C, Grolleau R (1989) Myosin: a highly sensitive indicator of myocardial necrosis after after cardiac operations. J Thorac Cardiovasc Surg 98:397–401

    PubMed  Google Scholar 

  38. Trask R, Billadello J (1990) Tissue-specific distribution and developmental regulation of M and B creatine kinase mRNAs. Biochim Biophys Acta 1049:182–188

    PubMed  Google Scholar 

  39. Varki A, Roby D, Watts H, Zatuchni J (1978) Serum myoglobin in acute myocardial infarction: a clinical study and review of the literature. Am Heart J 96:680–688

    PubMed  Google Scholar 

  40. Vasudevan G, Mercer D, Varat M (1978) Lactic dehydrogenase isoenzyme determination in the diagnosis of acute myocardial infarction. Circulation 57:1055–1057

    PubMed  Google Scholar 

  41. Weeds A, Pope B (1971) Chemical studies on light chains from cardiac and skeletal muscle myosin. Nature 234:85–88

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Cardiology, University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria

    S. Hornykewycz, H. Gabriel & K. Huber

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  1. S. Hornykewycz
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  2. H. Gabriel
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  3. K. Huber
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Hornykewycz, S., Gabriel, H. & Huber, K. Biochemical markers of myocardial necrosis in acute myocardial infarction and thrombolysis. Ann Hematol 69, S59–S63 (1994). https://doi.org/10.1007/BF02215959

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