Abstract
Purpose
After noticing specific aberrant forms of development in preimplantation embryos from women with endometriosis, we embarked upon this study in order to examine the frequency of these events as compared with controls.
Methods
A total of 235 embryos representing 30 women undergoing 56 cycles of in vitrofertilization were retrospectively analyzed on videotape and placed into categories based upon the incidence of specific morphological criteria found during observations made on the first and second days following oocyte retrieval.
Results
Several of the aberrant nuclear and cytoplasmic events were found to be statistically increased in the group of embryos from women with endometriosis.
Conclusions
The incidence of defined aberrant phenotypes in embryos from women with laparoscopically documented endometriosis may allow us to identify specific embryotoxic events with reference to endometriosis and other diagnoses.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ron-El R, Nachum H, Herman A, Golan A, Caspi E, Soffer Y: Delayed fertilization and poor embryonic development associated with impaired semen quality. Fertil Steril 1991;55:338–344
Prainaud J, Mieusset R, Vieitez G, Labal B, Richoilley G: Influence of sperm parameters on embryo quality. Fertil Steril 1993;60:888–892
Fishel S, Jackson P, Webster J, Faratian B: Endotoxins in culture medium for human in vitro fertilization. Fertil Steril 1988;49:108–111
Vasquez-Levin M, Kaplan P, Guzman I, Grunfeld L, Garrisi GJ, Navot D: The effect of female antisperm antibodies on in vitro fertilization, early embryonic development, and pregnancy outcome. Fertil Steril 1991;56:84–88
Michaeli G, Fejgin M, Ghetler Y, Ben Nun I, Beyth Y, Amiel A: Chromosomal analysis of unfertilized oocytes and morphologically abnormal preimplantation embryos from an in vitro fertilization program. J in Vitro Fertil Embryo Transfer 1990;7:341–346
Damewood MD, Hesla JS, Schlaff WD, Hubbard M, Gearhart JD, Rock JA: Effect of serum from patients with minimal to mild endometriosis on mouse embryo development in vitro. Fertil Steril 1990;54:917–920
Simon C, Gomez E, Mir A, De los Santos M, Pellicer A: Glucocorticoid treatment decreases sera embryotoxicity in endometriosis patients. Fertil Steril 1992;58:284–289
Morcos RN, Gibbons WE, Findley WE: Effect of peritoneal fluid on in vitro cleavage of 2-cell mouse embryos: possible role in infertility associated with endometriosis. Fertil Steril 1985:44:678–683
Remohi J, Vidal A, Pellicer A: Oocyte donation in low level responders to conventional ovarian stimulation for in vitro fertilization. Fertil Steril 1993:59:1208–1215
Shulman A, Ben-Nun I, Ghetler Y, Kaneti H, Shilon M, Beyth Y: Relationship between embryo morphology and implantation rate after in vitro fertilization treatment in conception cycles. Fertil Steril 1993;60:123–126
Simon C, Gutierrez A, Vidal A, de los Santos MJ, Tarin JJ, Remohi J, Pellicer A: Outcome of patients with endometriosis in assisted reproduction: results from in-vitro fertilization and oocyte donation. Hum Reprod 1994;9:725–729
Mahmood TA, Messinis IE, Templeton A: Follicular development in spontaneous and stimulated cycles in women with minimal-mild endometriosis. Br J Obstet Gynaecol 1991;98: 783–788
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Brizek, C.L., Schlaff, S., Pellegrini, V.A. et al. Increased incidence of aberrant morphological phenotypes in human embryogenesis—An association with endometriosis. J Assist Reprod Genet 12, 106–112 (1995). https://doi.org/10.1007/BF02211378
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02211378