Summary
The case of a 38-year-old white female, with a long history of myasthenia gravis, who developed sarcoidosis is presented. The diagnosis of myasthenia gravis had been established on the basis of typical clinical symptoms with severe myastenic crises necessitating respiratory support, characteristic electromyographic findings, positive anti-acetylcholine receptor antibodies and response to appropriate medications. After 9 years of disease and while in apparent remission, she presented with ankle arthritis and bilateral hilar adenopathy. A transbronchial lung biopsy showed noncaseating granuloma, typical of sarcoidosis. To our knowledge, the combination of myasthenia gravis and sarcoidosis is extremely rare and emphasizes the intriguing tendency of some immunologic disorders to appear together in certain individuals.
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References
Theofilopoulos, A.N. Autoimmunity. In: Basic and Clinical Immunology, 6th ed., Eds.: Stites, D.P., Stobo, J.D., Wells, J.V., Norwalk, Appleton and Lange, 1987, 128–158.
Saper J.R., Fry, M.B. Sarcoidosis presenting as a mediastinal mass in a patient with myasthenia gravis. Dis Nerv Syst 1977, 38, 57–59.
Giordano, A.S., Haymond, J.L. Myasthenia gravis: A report of two cases with necropsy findings. Am J Clin Pathol 1944, 14, 253–265.
Namba, T., Bruner, N.G., Brob, D. Idiopathic giant cell polymyositis. Arch Neurol 1974, 31, 27–30.
Mendelow, H., Genkins, G. Studies in myasthenia gravis: Cardiac and associated pathology. Mt Sinai J Med 1954, 21, 218–225.
Burke, J.S., Medline, N.M., Katz, A. Giant cell myocarditis and myositis associated with thymoma and myasthenia gravis. Arch Pathol Lab Med 1969, 88, 359–366.
Rowland, L.P. Prostigmine responsiveness and the diagnosis of myasthenia gravis. Neurology 1955, 5, 612–624.
Powell, L.W. Jr. Sarcoidosis of skeletal muscle. Report of 6 cases and review of the literature. Am J Clin Pathol 1953, 23, 881–889.
Philips, R.W., Philips, A.M. The diagnosis of Boeck's sarcoid by skeletal muscle biopsy. Arch Intern Med 1956, 98, 732–736.
Silverstein, A., Siltzbach, L.E. Muscle involvement in sarcoidosis. Arch Neurol 1969, 21, 235–241.
Andonopoulos, A.P., Asimakopoulos, G., Mallioris, C., Karatza, C., Skopa, C. The diagnostic value of gastrocnemius muscle biopsy in sarcoidosis presenting with erythema nodosum and hilar adenopathy. Clin Rheumatol 1987, 6, 192–196.
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Andonopoulos, A.P., Papathanasopoulos, P.G., Karatza, C. et al. Sarcoidosis in a patient with myasthenia gravis. Case report and review of the literature. Clin Rheumatol 10, 323–325 (1991). https://doi.org/10.1007/BF02208700
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DOI: https://doi.org/10.1007/BF02208700