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Endogenous sex steroid levels in women with generalised osteoarthritis

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Summary

Epidemiologic and clinical observations have suggested a relationship between generalised osteoarthritis (GOA) and hormonal and menopausal factors in women. We explored the hypothesis that postmenopausal women with GOA have altered sex hormone status compared with control women. We studied 112 women (mean age 64) with GOA. Controls were 151 women (mean age 54) from the general population without clinical evidence of hand or knee OA. All women were postmenopausal. Serum was assayed by RIA for testosterone, oestradiol, sex hormone binding globulin (SHBG), and dyhydroepiandrosterone sulphate (DHEAS). Because of the differences in mean ages, the results were compared according to equal age groups divided on the basis of tertiles. SHBG was lower in the GOA group, reaching significance in the middle group 53–61 years (58.0 vs 67.9nmol/l p<0.05). Testosterone was slightly higher in GOA women aged under 53. No consistent differences were seen in the older age group or for the other sex steroids. These preliminary data suggest that middle-aged women with GOA have lower circulating SHBG levels. This implies that higher circulating free oestrogens and androgens are present suggesting a role in the aetiopathogenesis of GOA.

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References

  1. Lawrence, J.S., Rheumatism in populations. Heinemann, London, 1977.

    Google Scholar 

  2. Kellgren, J.H., Moore, R. Generalised osteoarthritis and Heberdens nodes. Br Med J 1952, 1, 181–187.

    PubMed  Google Scholar 

  3. Rogers, F.B., Lansbury, J. Urinary gonadotrophin secretion in osteoarthritis. Am J Med Sci 1956, 232, 419–420.

    PubMed  Google Scholar 

  4. Rubens-Duval, A., Villiauney, J., Baumgarter, P. Etude morphologique et biochemique de l'obesite des etats prearthrosiques. Pathol Biol 1957, 5, 1649.

    Google Scholar 

  5. Spector, T.D., Perry, L.A., Tubb, G., Huskisson, E.C. Androgen status of women with rheumatoid arthritis (letter). Br J Rheumatol 1987, 26, 316–318.

    PubMed  Google Scholar 

  6. Wathen, N.C., Perry, L.A., Rubenstein, E., Chard, T. A relationship between sex hormone building globulin and dehydroepi-androsterone sulphate in normally menstruating females. J Gynaecol Endocrinol 1987, I, 47–55.

    Google Scholar 

  7. Fattah, D.I., Chard, T. A simplified method for measuring sex hormone binding globulin. Clin Chemistry 1981, 27, 1277–1279.

    Google Scholar 

  8. Wood, P.H. Age and the rheumatic diseases. In: Population studies of the rheumatic diseases. Eds: Bennet, P.H., Wood, P.H. Excerpta Medica, Amsterdam, 4, 26–37.

  9. Neugarten, B.L., Kraines, R.J. “Menopausal symptoms” in women of various ages. Psychosom Med 1965, 27, 266–273.

    PubMed  Google Scholar 

  10. Nordin, E. C., Polley, K.J. Metabolic consequences of the menopause. Calcif Tissue Intern 1987, 41, s1-s59.

    Google Scholar 

  11. Spector, T.D., Brown, G.C., Silman, A.J. Increased rates of prior hysterectomy and gynaecological operations in women with osteoarthritis. Br Med J 1988, 297, 899–900.

    Google Scholar 

  12. Spector, T.D. The fat on the joint: obesity and osteoarthritis. J Rheumatol 1990, 17, 283–284.

    PubMed  Google Scholar 

  13. Davis, M.A., Ettinger, W.H., Neuhaus, J.M., Hauck, W.W. Sex differences in osteoarthritis of the knee. Am J Epidemiol, 1988, 127, 1019–30.

    PubMed  Google Scholar 

  14. Spector, Campion, G.C. Generalised osteoarthritis is a hormonally mediated disease. Ann Rheum Dis 1989, 48, 256–261.

    PubMed  Google Scholar 

  15. Seyedin, S.M., Thompson, A.Y., Benz, H., Rosen, D.M., Piez, K.A. Cartilage factor-A. J Biol Chem 1986, 261, 5693–5695.

    PubMed  Google Scholar 

  16. Holly, J.M.P., Wass, J.A.H., Insulin-like growth factors; autocrine, paracrine, or endocrine? New perspectives of the somatomedin hypothesis in the light of recent developments. J Endocrinol 1989, 122, 611–618.

    PubMed  Google Scholar 

  17. Holly, J.M.P., Smith, C.P., Dunger, D.B. et al.. Relationship between the pubertal fall in sex hormone binding globulin and insulin-like growth factor binding protein-1. A synchronised approach to pubertal development? Clin Endocrinol 1989, 31, 277–284.

    Google Scholar 

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Authors and Affiliations

  1. Department of Environmental and Preventive Medicine, Rheumatology, St Bartholomew's Hospital, EC1, London, UK

    T. D. Spector MSc MD MRCP

  2. Department of Reproductive Physiology, St Bartholomew's Hospital, EC1, London, UK

    L. A. Perry

  3. Department of Rheumatology, Selly Oak Hospital, Birmingham, UK

    R. W. Jubb

Authors
  1. T. D. Spector MSc MD MRCP
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  2. L. A. Perry
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  3. R. W. Jubb
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Spector, T.D., Perry, L.A. & Jubb, R.W. Endogenous sex steroid levels in women with generalised osteoarthritis. Clin Rheumatol 10, 316–319 (1991). https://doi.org/10.1007/BF02208698

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  • DOI: https://doi.org/10.1007/BF02208698

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