Summary
A 20 year follow up is reported on 100 patients with definite or classical rheumatoid arthritis when they were all initially seen within one year of the onset of arthritis. Forty-six patients have died and in 17 death was due to or related to RA. Mortality was greater in men than in women and in patients who had classical rather than definite RA at one year. Thirty of the surviving 54 patients have either no or only moderate restriction of physical activity. Those who had definite RA at one year are now better as regards functional capacity and joint score than those who had classical RA. In general the titre of the Rose test has tended to fall and those who have become seronegative have done better than those remaining seropositive.
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References
Cobb, S., Anderson, F., Bauer, W. Length of life and cause of death in rheumatoid arthritis. N Engl J Med, 1953, 249, 553–556.
Duthie, J.J.R., Brown, P.E., Truelove, L.H. Course and prognosis of rheumatoid arthritis. Ann Rheum Dis, 1964, 23, 193–202.
Reah, T.G. The prognosis of rheumatoid arthritis. Proc R Soc Med, 1963, 56, 813–817.
Uddin, J., Kraus, A.S., Kelly, H.G. Survivorship and death in rheumatoid arthritis. Arthritis Rheum, 1970, 13, 125–130.
Jacoby, R.K., Jayson, M.I.V., Cosh, J.A. Onset early stages and prognosis of rheumatoid arthritis. A clinical study of 100 patients with 11-year follow-up. Br Med J, 1973, i, 96–100.
Rasker, J.J., Cosh, J.A. The natural history of rheumatoid arthritis: a fifteen year follow-up study. The prognostic significance of features noted in the first year. Clin Rheumatol 1984, 1, 11–20.
Rasker, J.J., Cosh, J.A. Cause and age at death in a prospective study of 100 patients with rheumatoid arthritis. Ann Rheum Dis, 1981, 40, 115–120.
Vandenbroucke, J.P., Hazevoet, H.M., Cats, A. Survical and cause of death in rheumatoid arthritis: a 25 year prospective follow-up. J Rheumatol, 1984, 11, 158–161.
Cosh, J.A. Survival and death in rheumatoid arthritis (editorial). J Rheumatol, 1984, 11, 117–188.
Scott, D.L., Symmons, D.P.M. The mortality of rheumatoid arthritis: reports on rheumatic diseases. Arthritis and Rheum Council series 2. Topical reviews no 2, january 1986.
Scott, D.L., Couiton, B.L., Symmons, D.P.M., Popert, A.J. The outcome of treating rheumatoid arthritis for 20 years. Br J Rheumatol, 1986, 25, 6 (abstr. suppl).
Jaraquemada, D., Ollier, W., Awad, J., Young, A., Silman, A. et al. HLA and rheumatoid arthritis: a combined analysis of 440 British patients. Ann Rheum Dis, 1986, 45, 627–636.
Rudge, S.R., Drury, P.L., Lloyd Jones, J.K. Long term corticosteroids and cervical subluxations in non rheumatoid patients. Rheum Rehabil 1981, 20, 102–105.
Rasker, J.J., Cosh, J.A. Radiological study of cervical spine and hand in patients with rheumatoid arthritis of fifteen years duration: an assessment of the effect of corticostoid treatment. Ann Rheum Dis, 1978, 37, 529–535.
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Rasker, J.J., Cosh, J.A. The natural history of rheumatoid arthritis over 20 years. Clinical symptoms, radiological signs, treatment, mortality and prognostic significance of early features. Clin Rheumatol 6 (Suppl 2), 5–11 (1987). https://doi.org/10.1007/BF02203379
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DOI: https://doi.org/10.1007/BF02203379