Skip to main content
SpringerLink
Log in

Multiple primary tumors: 17 cases of renal-cell carcinoma associated with primary tumors involving different steroid-hormone target tissues

  • Free Paper
  • Published:
World Journal of Urology Aims and scope Submit manuscript

Abstract

The aim of this study was to analyze the characteristics of 17 women with renal-cell carcinoma (RCC) associated with other primary neoplasms occurring in steroid-hormone target tissues. The reproductive history of these patients and the use of exogenous hormones were taken into consideration. In all, 10 RCCs were associated with breast carcinoma; 4, with endometrial carcinoma; and 3, with ovarian carcinoma. The presentation of a second primary tumor was described as synchronous or metachronous by evaluation of the interval between the discovery of the two neoplasms. Hormone and surgical treatment as well as pathologic findings for each primary tumor were also reported. In these 17 RCCs the overall rate of disease-specific survival recorded after a mean follow-up period of 32.7 months (range 9–66 months) was 58.8%; 7 patients died of metastatic disease after surviving for a mean of 14.7 months. In terms of the pathologic stage of RCC, a significant difference in mean survival was found between pN0 (mean survival 22.1 ± 3.4 months) and pN 1 RCCs (mean survival 13.7 ± 3.5 months). A total of 13 (76.4%) women were postmenopausal at the time of diagnosis of the first primary tumor; the mean age of these women at menopause was 51.7 ± 1.2 years. No prior use of oral contraceptives was reported by 12 (70.5%) of the 17 patients. Plasma 17-beta-estradiol and estrone levels were determined in only 7 patients at the diagnosis of each of the primary tumors. High plasma estrogen levels were found in 4 women with RCC and breast carcinoma and in 1 patient with RCC and endometrial carcinoma; in the remaining 2 patients low-normal values were found. A relationship appears to exist between certain reproductive and hormone-related factors and the risk of developing these tumor associations. Data emerging from the present study do not provide strong support for the hypothesis of hormone dependency of RCC; however, a role for estrogens in cases in which RCC is associated with other primary tumors involving steroid-hormone target tissues can be hypothesized.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Banerjee SK, Banerjee S, Li SA, Li J (1991) Cyrogenetic changes in hamster rental tumor induced by estrogens. Proc Annu Meet Am Assoc Cancer Res 32: 967A

    Google Scholar 

  2. Bath HK, Hacker HJ, Baunasch P, Thompson EA, Liehr JG (1993) Localization of estrogen receptors in interstitial cells of hamster kidney and in estradiol-induced renal tumors as evidence of the mesenchymal origin of this neoplasm. Cancer Res 53:5447–5451

    Google Scholar 

  3. Billroth T (1889) Ein Handbuch fur studierende and Ärtze, 14th edn. Rerimer, Berlin, p 908

    Google Scholar 

  4. Blom JHM (1993) The role of lymphadenectomy in association with radical nephrectomy. Curr Opin Urol 3: 359–362

    Google Scholar 

  5. Briand P (1983) Hormone-dependent mammary tumors in mice and rats as a model for human breast cancer. Anticancer Res 3: 273–282

    Google Scholar 

  6. Bullock LP, Bardin WC (1974) Androgen receptors in mouse kidney: a study of male, female and androgen insensitive mice. Endocrinology 94: 746–756

    Google Scholar 

  7. Bursch W, Liehr JG, Sirbasku DA, Putz B, Taper H, ShulteHermann R (1991) Control of cell death (apoptosis) by diethylstilbestrol in an estrogen-dependent kidney tumor. Carcinogenesis 12: 855–860

    Google Scholar 

  8. Chow WH, McLaughlin JK, Mandel JS, Blot WS, Niwa S, Fraumeni JF Jr (1995) Reproductive factors and risk of renal cell cancer among women. Int J Cancer 60: 321–324

    Google Scholar 

  9. Concolino G, Marocchi A, Concolino F, Sciarra F, Di Silverio F, Conti C (1996) Human kidney steroid receptors. J Steroid Biochem 10: 831–835

    Google Scholar 

  10. Concolino G, Di Silverio F, Marocchi A, Bracci U (1979) Renal cancer steroid receptors: biochemical basis for endocrine therapy. Eur Urol 5: 90–93

    Google Scholar 

  11. Concolino G, Di Silverio F, Tenaglia R, Marocchi A (1981) Tumori primitivi multipli: carcinoma renale associato a neoplasie di altri organi barsaglio. J Endocrinol Invest 4 [suppl 1]: 455–458

    Google Scholar 

  12. Concolino G, Lubrano C, Santonati A, Di Silverio F, Catizone A, Conti C (1989) Epidermal growth factor binding by normal and neoplastic human renal tissue. J Tumor Marker Oncol 4: 89–97

    Google Scholar 

  13. Cortes-Vizcaino V, Llombart-Bosch A (1993) Estrogen and progesterone receptors in the diethylstilbestrol-induced kidney neoplasms of Syrian golden hamster: correlation with histopathology and tumoral stages. Carcinogenesis 14: 1215–1219

    Google Scholar 

  14. Ferrigno D (1991) Synchronous pulmunary and renal cancer. Chest 100:587

    Google Scholar 

  15. Giuliani L, Gilberti C, Martorana G, Rovida S (1990) Radical extensive surgery for renal carcinoma: long term results and prognostic factors. J Urol 143: 468–474

    Google Scholar 

  16. Golimbu M, Joshi P, Sperber A, Tessler A, Al-Askari S, Morales P (1986) Renal cell carcinoma: survival and prognostic factors. Urology 27: 291–301

    Google Scholar 

  17. Li JJ, Gonzales A, Banerjee S, Banerjee SK (1993) Estrogen carcinogenesis in the hamster kidney: role of cytotoxicity and cell proliferation. Environ Health Perspect 101 [Suppl 5] 259–264

    Google Scholar 

  18. Lindbland P, Mellemgaaed A, Schlehofer B, Adami H, McCredie M, McLaughlin JK, Mandel JS (1995) International renal cell cancer study. V. Reproductive factors, gynecologic operations and exogenous hormones. Int J Cancer 61: 192–198

    Google Scholar 

  19. Lapis MT (1991) Combination of malignant tumors of the genitourinary system in the same patient: testicular seminoma, renal adenocarcinoma and adenocarcinoma of the prostate. Arch Esp Urol 44: 73–75

    Google Scholar 

  20. McNichols DW, Segura JW, Weerd JH de (1981) Renal cell carcinoma: long term survival and late recurrence. J Urol 126: 17

    Google Scholar 

  21. Murray PA, Gomm J, Ricketts D, Powles T, Coombes RC (1994) The effect of endocrine therapy on the levels of estrogen and progesterone receptors and transforming growth factor beta 1 in metastatic human breast cancer: an immuncytochemical study. Eur J Cancer 30A: 1218–1222

    Google Scholar 

  22. Muscat JE, Hoffmann D, Wynder EL (1995) The epidemology of renal cell carcinoma. A second look. Cancer 75: 2552–2557

    Google Scholar 

  23. Nason FG, Nelson BE (1994) Estrogen and progesterone in breast and gynecologic cancers. Etiology, therapeutic role and hormone replacement. Obstet Gynecol Clin North Am 21: 245–270

    Google Scholar 

  24. Shen J, Son HJ, Liu TH (1994) Synchronous primary cancers of endometrium and ovary. Chung Hua Fu Chan Ko Tsa Chih 29: 498–501

    Google Scholar 

  25. Sirbasku DA (1978) Estrogen induction of growth factors specific for hormone-responsive mammary, pituitary and kidney tumor cells. Proc Natl Acad Sci USA 75: 3786–3790

    Google Scholar 

  26. Vecek N, Nola M, Marisuc M, Ilic J, Babic D, Petrovecki M, Nikolic S, Marinovic T, Jukic D, Vecekn J (1994) Prognostic value of steroid receptor concentration in patients with endometrial carcinoma. Actal Obstet Gynecol Scand 73: 730–733

    Google Scholar 

  27. Vessey MP, Painter R (1995) Endometrial and ovarian cancer and oral contraceptives: findings in a long cohort study. Br J Cancer 71: 1340–1342

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology U. Bracci, University of Rome La Sapienza, Via le Policlinico, I-00161, Rome, Italy

    F. Di Silverio, A. Sciarra, G. P. Flammia, M. Mariani & A. De Vico

Authors
  1. F. Di Silverio
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Sciarra
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. P. Flammia
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Mariani
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. De Vico
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Di Silverio, F., Sciarra, A., Flammia, G.P. et al. Multiple primary tumors: 17 cases of renal-cell carcinoma associated with primary tumors involving different steroid-hormone target tissues. World J Urol 15, 203–209 (1997). https://doi.org/10.1007/BF02201858

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02201858

Keywords

Search

Navigation