Summary
Described herein is the effect of several drug classes on suppressing isolation-induced fighting behavior. A diverse group of drugs was found to have an inhibitory effect on this form of behavior. Also included is our method of assay adapted from the work of others in which training and isolation are combined to produce agonistic behavior. This increases the number of fighters. Isolation appeared to be more important than training in the development of fighting behavior under our conditions. Fewer animals developed fighting behavior in summer than in other seasons. No differences were found between fighters and non-fighters with regard to the serum corticosterone levels and the content of brain serotonin and norepinephrine.
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DaVanzo, J.P., Daugherty, M., Ruckart, R. et al. Pharmacological and biochemical studies in isolation-induced fighting mice. Psychopharmacologia 9, 210–219 (1966). https://doi.org/10.1007/BF02198481
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DOI: https://doi.org/10.1007/BF02198481