Abstract
We report six cases of protein S deficiency secondary to varicella. Five cases were complicated by thrombotic and vascular events, namely purpura fulminans and necrotic vasculitis, deep vein thrombosis and stroke. Two cases were associated with protein C deficiency and one case revealed a heterozygous factor XII deficiency. The underlying mechanism of this acquired protein S deficiency is unclear but could be related to a direct effect of zoster virus.
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Abbreviations
- APTT :
-
activated partial thromboplastin time
- ATIII :
-
antithrombin III
- DIC :
-
disseminated intravascular coagulation
- PS:
-
protein S
- IPG :
-
impedance plethysmography
- PT:
-
prothrombin time
- C4bBP :
-
C4b binding protein
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Nguyên, P., Munzer, M., Reynaud, J. et al. Varicella and thrombotic complications associated with transient protein C and protein S deficiencies in children. Eur J Pediatr 153, 646–649 (1994). https://doi.org/10.1007/BF02190684
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DOI: https://doi.org/10.1007/BF02190684