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Abnormal topography of EEG microstates in Gilles de la Tourette syndrome

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Abstract

Quantitative analysis of scalp EEGs was performed on 13 patients with Gilles de la Tourette syndrome (GTS) and 25 matched controls. The analysis method was adaptive segmentation, which describes the topography and sequence of brain electric fields in continuous EEG. The GTS patients showed an abnormal increase in fields with a right-frontal/left-posterior configuration. The GTS patient's EEGs did not differ from normal controls in the average duration of the brain electric microstates, field stability and EEG carrier frequency. To find out whether the abnormal activity is similar to movement-related activity a simple and a complex motor task were performed. Both tasks led to distinct changes of brain electric activity, but not to an increase in right-frontal-/left-posterior-oriented patterns. Motor-related activity was contrasted with two auditory tasks. We conclude that GTS patient's EEG show abnormal topographic patterns of brain electric activity. Unlike other psychiatric disorders, the temporal descriptors of the EEG aspects are unaffected. The abnormal EEG patterns in GTS patients are not similar to those elicited by simple or complex movements; thus, the presence of abnormally facilitated, near-threshold motor activity in GTS patients seems not a likely explanation.

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References

  • Alexander GE, De Long MR, Strick PL (1986) Parallel organisation of functionally segregated circuits linking basal banglia and cortex. Annu Rev Neurosci 9:357–381

    Google Scholar 

  • American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders (DSM-III-R), 3rd ed, revised. American Psychiatric Association, Washington, DC

    Google Scholar 

  • Baxter L, Schwartz J, Maziotta J, Phelps ME, Pahl JJ, Buze BE, Fairbanks L (1988) Cerebral glucose metabolic rates in nondepressed patients with obsessive-compulsive disorder. Am J Psychiatry 145:1560–1563

    Google Scholar 

  • Beech HR, Ciesielski KT, Gordon PK (1983) Further observations of evoked potential in obsessional patients. Br J Psychiatry 142: 605–609

    Google Scholar 

  • Bonnet KA (1982) Neurobiological dissection of Tourette syndrome: a neurochemical focus on a human neuroanatomical model. In: Friedhoff AJ, Chase TN (eds) Gilles de la Tourette syndrome. Raven Press, New York, pp 77–82

    Google Scholar 

  • Buzsaki G, Chrobak JJ (1995) Temporal structure in spatially organized neuronal ensembles: a role for interneuronal networks. Curr Opin Neurobiol 5:504–510

    Google Scholar 

  • Destexhe A, Babloyantz A (1991) Deterministic chaos in a model of the thalamo-cortical system. In: Babloyantz A (ed) Self-organization, emerging properties and learning. Plenum Press, New York, pp 127–150

    Google Scholar 

  • Drake ME Jr, Hietter SA, Padamadan H, Bogner JE, Andrews JM, Weate S (1992) Auditory evoked potentials in Gilles de la Tourette syndrome. Clin Electroencephalogr 23:19–23

    Google Scholar 

  • Eapen V, Pauls DL, Robertson MM (1993) Evidence for autosomal transmission in Tourette's syndrome. United Kingdom cohort study. Br J Psychiatry 162:593–596

    Google Scholar 

  • Erenberg G, Cruse RP, Rothner AD (1987) The natural history of Tourette's syndrome: a follow-up study. Ann Neurol 22:383–385

    Google Scholar 

  • Gerorge MS, Trimble MR, Costa DC, Robertson MM, Ring HA, Ell PJ (1992) Elevated frontal blood flow in Gilles de la Tourette syndrome: a99Tcm-HMPAO SPECT study. Psychiatry Res 45:143–151

    Google Scholar 

  • Gratton G, Coles M, Donchin E (1983) A new method for off-line removal of ocular artfact. Electroencephalogr Clin Neurophysiol 44:735–741

    Google Scholar 

  • Günther W, Müller N, Trapp W, Haag C, Putz A, Straube A (1996) Quantitative EEG analysis during motor function and music preception in Tourette's syndrome. Eur Arch Psychiatry Clin Neurosci 246:197–202

    Google Scholar 

  • Harcherik DF, Leckman JF, Detlor J, Cohen DJ (1984) A new instrument for clinical studies of Tourette's syndrome. J Am Acad Child Psychiatry 23:153–160

    Google Scholar 

  • Hyde TM, Emsellem HA, Randolph C, Rickler KC, Weinberger DR (1994) Electroencephalographic abnormalities in monozygotic twins with Tourette's syndrome. Br J Psychiatry 164: 811–817

    Google Scholar 

  • IFSCEN (1974) A glossary of terms commonly used by clinical electroencephalographers. Electroencephalogr Clin Neurophysiol 37:538–548

    Google Scholar 

  • Insel TR (1992) Toward a neuroanatomy of obsessive-compulsive disorder. Arch Gen Psychiatry 49:739–744

    Google Scholar 

  • Koukkou M, Lehmann D, Strik WK, Merlo MC (1994) Maps of microstate of spontaneous EEG in never-treated acute schizophrenia. Brain Topogr 6:251–252

    Google Scholar 

  • Krumholz A, Singer HS, Niedermeyer E, Burnite R, Harris K (1983) Electrophysiological studies in Tourette's syndrome. Ann Neurol 14:638–641

    Google Scholar 

  • Lang AE (1993) Premonitory (“sensory”) experiences. In: Kurlan R (ed) Handbook of Tourette's syndrome and related tic and behavioural disorders. Dekker, New York, pp 17–26

    Google Scholar 

  • Leckman JF, Riddle MA, Hardin MT et al. (1989) The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity. J Am Acad Child Psychiatry 28:566–573

    Google Scholar 

  • Leckman JF, Goodman WK, Anderson GM, Riddle MA, Chappell PB (1995) Cerebrospinal fluid biogenic amines in obsessive-compulsive disorder, Tourette's syndrome and healthy controls. Neuropsychopharmacology 12:73–86

    Google Scholar 

  • Lehmann D, Ozaki H, Pal I (1987) EEG alpha map series: brain micro-states by space-oriented adaptive segmenation. Electroencephalogr Clin Neurophysiol 67:271–288

    Google Scholar 

  • Lopes da Silva FH (1991) Neural mechanisms underlying brain waves: from neural membranes to networks. Electroencephalogr Clin Neurophysiol 79:81–89

    Google Scholar 

  • Lopes da Silva FH, Storm van Leeuwen W (1977) The cortical source of the alpha rhythm. Neurosci Lett 6:237–241

    Google Scholar 

  • Malison RT, McDougle CJ, van-Dyck CH, Scahill L, Baldwin RM, Seibl JP, Price LH, Leckmann JF, Innis RB (1995) 123beta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder. Am J Psychiatry 152:1359–1361

    Google Scholar 

  • Merzenich MM, Schreiner C, Jenkins W, Wang X (1993) Neural mechanism underlying temporal integration, segmentation and input sequence representation: some implications for the origin of learning disabilities. In: Tallal P, Galaburda AM, Llinas RR, Euler C von (eds) Temporal information processing in the nervous system: special reference to dyslexia and dysphasia. Ann NY Acad Sci 682:1–22

  • Moriarty J, Costa DC, Schmitz B, Trimble MR, Ell PJ, Robertson MM (1995) Brain perfusion abnormalities in Gilles de la Tourette's syndrome. Br J Psychiatry 167:249–254

    Google Scholar 

  • Murthy VN, Fetz EE (1992) Coherent 25-to 30-Hz oscillations in the sensorimotor cortex of awake behaving monkeys. Proc Natl Acad Sci USA 89:5670–5674

    Google Scholar 

  • Nashmi R, Mendonca AJ, MacKay WA (1994) EEG rhythms of the sensorimotor region during hand movements. Electroencephalgr Clin Neurophysiol 91:456–467

    Google Scholar 

  • Obeso JA, Rothwell JC, Marsden CD (1981) Simple tics in Gilles de la Tourette's syndrome are not prefaced by a normal premovement EEG potential. J Neurol Neurosurg Psychiatry 44: 735–738

    Google Scholar 

  • Pauls DL, Towbin KE, Leckman JF, Zahner GEP, Cohen DJ (1986) Gilles de la Tourette syndrome and obsessive-compulsive disorder: evidence supporting an etiological relationship. Arch Gen Psychiatry 43:1180–1182

    Google Scholar 

  • Peterson B, Riddle MA, Cohen DJ, Katz LD, Smith JC, Hardin MT, Leckman JF (1993) Reduced basal ganglia volumes in Tourette's syndrome using three-dimensional reconstruction techniques from magnetic resonance images. Neurology 43: 941–949

    Google Scholar 

  • Pfurtscheller G, Neuper C (1992) Simultaneous EEG 10-Hz desynchronization and 40-Hz synchronization during finger movements. NeuroReport 3:1057–1060

    Google Scholar 

  • Riddle MA, Rasmusson AM, Woods SW, Hoffer PB (1992) SPECT imaging of cerebral blood flow in Tourette syndrome. Adv Neurol 58:207–211

    Google Scholar 

  • Robertson MM, Trimble MR, Lees AJ (1988) The psychopathology of the Gilles de la Tourette syndrome. Br. J Psychiatry 152:383–390

    Google Scholar 

  • Robertson MM, Yakeley JW (1993) Obsessive-compulsive disorder and self-injurious behavior. In: Kurlan R (ed) Handbook of Tourette's syndrome and related tic and behavioural disorders. Dekker, New York, pp 45–88

    Google Scholar 

  • Rubin RT, Villanueva-Meyer J, Ananth J, Trajmar PG, Mena I (1992) Regional xenon 133 cerebral blood flow and cerebral technetium Tx 99m-HMPAO uptake in unmedicated patients with obsessive-compulsive disorder and matched normal control subjects: determination by high-resolution single-photonemission computed tomography. Arch Gen Psychiatry 49: 695–702

    Google Scholar 

  • Shagass C, Roemer RA, Straumanis JJ, Josiassen RC (1984a) Distinctive somatosensory evoked potential featues in obsessivecompulsive disorder. Biol Psychiatry 19:1507–1524

    Google Scholar 

  • Shagass C, Roemer RA, Straumanis JJ, Josiassen RC (1984b) Evoked potentials in obsessive-compulsive disorder. Adv Biol Psychiatry 15:69–75

    Google Scholar 

  • Singer HS, Reiss AL, Brown JE et al. (1993) Volumetric MRI changes in basal ganglia of children with Tourette's syndrome. Neurology 43:950–956

    Google Scholar 

  • Steriade M, Dossi C, Oakson G (1991) Fast oscillations (20–40 Hz) in thalamocortical systems and their potentiation by mesopontine cholinergic nuclei in the cat. Proc Natl Acad Sci USA 88:4396–4400

    Google Scholar 

  • Stevens A, Lutzenberger W, Bartels M, Strik W, Lindner K. Increased duration and altered topography of EEG microstates during cognitive tasks in chronic schizophrenia. Psychiatry Res (in press)

  • Strik WK, Lehmann D (1993) Data-determined window size and space-oriented segmentation of spontaneous EEG map series. Electroencephalogr Clin Neurophysiol 87:169–174

    Google Scholar 

  • Strik WK, Dierks T, Becker T (1995) Larger topographical variance and increased duration of brain electric microstates in depression. J Neural Transm (GenSect) 99:213–222

    Google Scholar 

  • Swedo SE, Schapiro MB, Grady CL, Cheslow DL, Leonard HL, Kumar A, Friedland R, Rappoport SI, Pappoport JL (1989) Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder. Arch Gen Psychiatry 46:518–523

    Google Scholar 

  • Towbin KE, Riddle MA (1993) Attention deficit hyperactivity disorder. In: Kurlan R (ed) Handbook of Tourette's syndrome and related tic and behavioural disorders. Dekker, New York, pp 89–110

    Google Scholar 

  • Towey JP, Tenke CE, Bruder GE, Leite P, Friedman D, Liebowitz M, Hollander E (1994) Brain event-related potential correlates of overfocused attention in obsessive-compulsive disorder. Psychophysiol 31:535–543

    Google Scholar 

  • Verma NP, Syrigou-Papavasiliou A, LeWitt PA (1986) Electroencephalographic findings in unmedicated, neurologically and intellectually intact Tourette syndrome patients. Electroencephalogr Clin Neurophysiol 564:12–20

    Google Scholar 

  • Volkmar FR, Leckman JF, Detlor J et al. (1984) EEG abnormalities in Tourette's syndrome. J Am Acad Child Adolesc Psychiatry 23:352–353

    Google Scholar 

  • Wackermann J, Lehmann D, Michel CM, Strik WK (1993) Adaptive segmentation of spontaneous EEG map series into spatially defined microstates. Int J Psychophysiol 14:269–283

    Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry, University of Tübingen, Osianderstr. 22, D-72076, Tübingen, Germany

    A. Stevens & M. Bartels

  2. Department of Psychiatry, Munich and Nervenklinik Bamberg, Munich, Germany

    W. Günther & N. Müller

  3. Department of Medical Psychology and Behavioral Neurobiology, University of Tübingen, D-72076, Tübingen, Germany

    W. Lutzenberger

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  1. A. Stevens
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  2. W. Günther
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  3. W. Lutzenberger
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  4. M. Bartels
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  5. N. Müller
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Stevens, A., Günther, W., Lutzenberger, W. et al. Abnormal topography of EEG microstates in Gilles de la Tourette syndrome. Eur Arch Psychiatry Clin Nuerosci 246, 310–316 (1996). https://doi.org/10.1007/BF02189024

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