Zur Frage der Hemmung des Thiouracilkropfes der Ratte

Summary

The inhibition of thiouracil goitre in the rat by the methyl ether of vitamin A reported in previous investigations is not to be referred to vitamin A, but to the iodine that is bound to vitamin A in the course of its synthesis.

The relation between thiouracil and iodine compounds with different mobility of the iodine: NaI (II), the iodine-containing methyl ether of vitamine A (III), 2:4-dioxo-3:3-diethyl-5-iodine-tetrahydropyridin (IV),N-(4-oxy-3:5-diiodine-benzoyl)-diiodine-DL-tyrosine (V), and 1:4-dioxy-2:3-diiodine-buten-(2) were studied in the thyroid gland of the rat by histological investigation of the degree of development of the thiouracil goitre and by determination of the iodine content of the thyroid. The iodine deprivation caused by thiouracil is definitely inhibited by the iodine compounds named, regardless of the motility of the iodine. The histologically demonstrable thiouracil goitre is likewise inhibited by these compounds, and here the degree of inhibition increases with the motility of the iodine.