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Cerebrospinal fluid absorption in the rabbit

Optic pathways

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Abstract

Fifteen rabbits were intrathecally perfused with horseradish peroxidase at normal cerebrospinal fluid pressures. Horseradish peroxidase was found in the subarachnoid space around the optic nerve; it permeated the pia and penetrated within the nerve, occupying extracellular spaces between myelinated axons and glial cells up to the area of the lamina cribrosa. Horseradish peroxidase also crossed the perineural sclera and the border tissue of Elschnig to spread into the choroid where it was mostly seen within choriocapillaris, venules, and veins crossing through interendothelial spaces. “Bulk” cerebrospinal fluid absorption in the eye appears to occur through venous drainage in the choroid and SAS.

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Authors and Affiliations

  1. Department of Radiology, Neuroradiology Research Laboratory, Harkness Research Building, Cornell University Medical College (Room A-667), 10021, New York, NY, USA

    D. G. Gomez, R. P. Manzo & D. G. Potts

  2. Membrane Transport Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    J. D. Fenstermacher

Authors
  1. D. G. Gomez
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  2. R. P. Manzo
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  3. J. D. Fenstermacher
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  4. D. G. Potts
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Additional information

This work was supported by NIH Grant RO1 NS13844

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Gomez, D.G., Manzo, R.P., Fenstermacher, J.D. et al. Cerebrospinal fluid absorption in the rabbit. Graefe's Arch Clin Exp Ophthalmol 226, 1–7 (1988). https://doi.org/10.1007/BF02172707

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  • DOI: https://doi.org/10.1007/BF02172707

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