Abstract
Two children with juvenile rheumatoid arthritis (JRA) were given photosensitive dye Platonin in combination with prednisolone. Analysis of clinical and laboratory data showed that Platonin was efficacious in the improvement of the clinical symptoms and the severity of inflammation, or in the maintenance of the remission state. There were no adverse side effects during long-term administration of medication.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- CRP:
-
C-reactive protein
- ESR:
-
erythrocyte sedimentation rate
- JRA:
-
juvenile rheumatoid arthritis
References
Brewer EJ Jr, Giannini EH, Barkley E. Gold therapy in the management of juvenile rheumatoid arithritis. Arthritis Rheum 1980; 23: 404–11.
Morimoto C, Reinherz EL, Borel Y, Mantzouranis E, Steinberg AD, Schlossman SF. Autoantibody to an immunoregulatory inducer population in patients with juvenile rheumatoid arthritis. J Clin Invest 1981; 67: 753–61.
Yamamoto I, Naitoh M. Platonin (NK-19) as a modulator of immune responses. Effects onin vitro PFC response and 3H-thymidine uptake in murine lymphocytes. Med Res Photosensitizing Dyes (in Japanese) 1981; 88: 31–9.
Yamamoto I, Nakayama T. Comparison of the effects of Platonin and Lumin on mitogen-induced blastformation and antibody response to DNP-Ficoll in mouse spleen lymphocytes. Med Res Photosensitizing Dyes (in Japanese) 1981; 88: 57–8.
Kondo N, Ko H, Motoyoshi F, Orii T. B cell suppressing and CD8+ T cell enhancing effects of photosensitive dye Platonin in humans. J Rheumatol 1989; 16: 936–9.
Abe S. Clinical evaluation of NK-19 (platonin) on rheumatoid arthritis. Jpn J Inf (in Japanese) 1984; 4: 2559.
Terawaki T. Clinical study of juvenile rheumatoid arthritis. J Japan Pediatr Society (in Japanese) 1981; 85: 801–2.
Forre Ø, Dobloug JH, Høyerral HM, Thorsby E. HLA antigens in juvenile arthritis; genetic basis for the different subtypes. Arithritis Rheum 1983; 26: 35–8.
Arnaud PR, Galbraith RM, Faulk WP, Ansell BM. Increased frequency of the MZ phenotype of alpha-lprotease inhibitor in juvenile chronic polyarthritis. J Clin Invest 1977; 60: 1442–4.