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The degradation of deoxyribonucleic acid by new tumour inhibiting compounds: The intermediate formation of hydrogen peroxide

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Zusammenfassung

Methylhydrazinderivate wie 1-Methyl-2-p-(isopropylcarbamoyl) benzyl-hydrazin-hydrochlorid und 1-Methyl-2-p-allophanoylbenzyl-hydrazin-hydrobromid bewirken unter aeroben Bedingungen einen Viskositätsabfall der wässerigen Lösungen von Desoxyribonucleinsäure. Es wird gezeigt, dass dieser Effekt auf die Bildung von Wasserstoffperoxyd bei der Autoxydation der Methylhydrazinverbindungen zurückzuführen ist. Auf die Analogie zum indirekten Effekt von Röntgenstrahlen wird hingewiesen.

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Authors and Affiliations

  1. Forschungsabteilung, F. Hoffmann-La Roche & Co. AG., Basel, Switzerland

    K. Berneis, M. Kofler, W. Bollag, A. Kaiser & A. Langemann

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  1. K. Berneis
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  2. M. Kofler
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  3. W. Bollag
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  4. A. Kaiser
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  5. A. Langemann
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Berneis, K., Kofler, M., Bollag, W. et al. The degradation of deoxyribonucleic acid by new tumour inhibiting compounds: The intermediate formation of hydrogen peroxide. Experientia 19, 132–133 (1963). https://doi.org/10.1007/BF02171591

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